Vincenzo Crunelli

Detecting seizure onset and offset times using human intelligence: A critical-transitions-based approach

Andrew Flynn, Cian McCafferty, Klaus Lehnertz, François David et autres

Most existing seizure detection algorithms require extensive pre-processing of the data and rely on heuristic or currently unexplainable machine learning approaches. These approaches often struggle with balancing detection sensitivity and specificity in the presence of variable seizure morphologies, interictal epileptiform discharges, and …

Detecting seizure onset and offset times using human intelligence: A critical-transitions-based approach

Andrew Flynn, Cian McCafferty, Klaus Lehnertz, François David et autres

Most existing seizure detection algorithms require extensive pre-processing of the data and rely on heuristic or currently unexplainable machine learning approaches. These approaches often struggle with balancing detection sensitivity and specificity in the presence of variable seizure morphologies, interictal epileptiform discharges, and …

ie, pt (code pays fourni par la source)

Thalamic 5-HT2A receptor activation reduces GABA uptake, increases tonic GABAA inhibition and induces absence seizures in Wistar rats

Vincenzo Crunelli, Tatiana P. Morais, William M. Connelly, Giulia Salamanca et autres

ABSTRACT Renewed interest in psychedelic therapeutics has brought serotonin 5-HT 2A receptors (5-HT 2A Rs) back into focus. Given the role of the thalamus in sensory integration and network synchronization, we examined the expression, developmental regulation, and functional impact of thalamic 5-HT …

gb, pt, au, it (code pays fourni par la source)

Developmental and cell type‐specific contributions of thalamic serotonin 2A receptors to absence seizures

Tatiana P. Morais, Giulia Salamanca, Sandra H. Vaz, Ana Maria Sebastião et autres

Abstract Objective Serotonin 2A receptors (5‐HT 2A Rs) play a complex role in focal and generalized seizures due to their diverse cellular and regional distribution. Although systemic activation of 5‐HT 2A Rs suppresses absence seizures (ASs) in Genetic Absence Epilepsy Rats From …

pt, mt, gb, it, jp (code pays fourni par la source)

Circuit‐Selective FAAH Inhibition Suppresses Experimental Absence Seizures

Tatiana P. Morais, Cristiano Bombardi, Vincenzo Crunelli, Giuseppe Di Giovanni

BACKGROUND: Childhood absence epilepsy (CAE) arises from dysfunctional corticothalamic networks generating spike wave discharges (SWDs) and behavioral arrest. Despite available treatments, a significant proportion of patients remain pharmacoresistant and develop neuropsychiatric comorbidities. The endocannabinoid system (ECS), through activity-dependent signaling, is a key …

mt, gb, it, pt, jp (code pays fourni par la source)

Heterogeneity of ictal firing during generalized seizures in the awake cortex

Péter Sere, Nikolett Zsigri, Vincenzo Crunelli, Magor L. Lörincz

Cortico-thalamo-cortical oscillations are central to both normal and pathological brain activities and emerge from complex cortical and thalamic interactions. However, the specific activity of identified cortical neurons during the paroxysmal oscillations associated with absence seizures (ASs) in awake animals remains underexplored. The …

hu, pt, gb (code pays fourni par la source)

Thalamic distribution and effects of 5-HT2C receptors on tonic GABAA inhibition and absence seizures: implications for treatment

Anna Cavaccini, Marcello Venzi, Cristiano Bombardi, Vincenzo Crunelli et autres

Introduction Childhood absence epilepsy (CAE) is associated with abnormal thalamocortical oscillations and enhanced GABAergic function in the ventrobasal (VB) thalamus, including increased extrasynaptic GABA A receptor–mediated tonic currents in thalamocortical (TC) neurons. Serotonin signaling modulates seizure activity in several epilepsy models, and …

ch, gb, it, pt, cz, kr (code pays fourni par la source)

Cortico-thalamic excitatory-inhibitory dynamics generates α -wave transient patterns encoding anesthetic brain states

François David, Christophe Sun, Pierre-Olivier Michel, Sibille Jérémie et autres

Abstract The neuronal circuits generating α frequency (8-13Hz) oscillatory patterns during anesthesia are poorly understood, making their use difficult in predictive medicine. Here, we combine large-scale in vivo recordings of thalamocortical neuronal ensembles in anesthetized mice with a minimal neural mass model. …

fr, de, pt, gb (code pays fourni par la source)

Impairment of Spatial Working Memory but Preservation of Recognition Memory in Female Rats with Spontaneous Absence Seizures

Mariana Neuparth‐Sottomayor, Tatiana P. Morais, Mark A. Good, Ana Maria Sebastião et autres

Epidemiological studies reveal gender-specific differences in epilepsy. Childhood absence epilepsy (CAE), which is more prevalent in females, is characterized by typical absence seizures (ASs) consisting of brief periods of unconsciousness, associated with 2.5-4 Hz spike-wave discharges (SWDs) in the electroencephalogram (EEG). Children …

pt, gb, it (code pays fourni par la source)

Bidirectional control of generalized absence epilepsy networks via real-time direct depolarization of thalamocortical neurons

Tatiana P. Morais, Hannah Lund Taylor, Olivér Nagy, Ferenc Mátyás et autres

Absence seizures (ASs), characterized by bilateral spike-and-wave discharges (SWDs), are a hallmark of idiopathic generalized epilepsies. We investigated the role of thalamocortical (TC) neurons in the generation and termination of ASs using optogenetic techniques in freely behaving GAERS rats, a well-established AS …

gb, hu, fr (code pays fourni par la source)

Excitation-Inhibition Balance in Absence Seizure Ictogenesis

Magor L. Lörincz, Vincenzo Crunelli, François David

Abstract Thirty percent of children with absence seizures are pharmaco-resistant, and 60% suffer from neuropsychiatric comorbidities that often persist even after full pharmacological control of the seizures. This highlights the need for a detailed comprehension of the cellular and network mechanisms of …

Corticothalamic Network Abnormalities Underlying Absence Seizures

Nathalie Leresche, Vincenzo Crunelli

Abstract Absence seizures (ASs) are genetic generalized seizures and one of the critical neurological phenotypes that originate from abnormalities in corticothalamic (CT) networks. Genetic analyses of cohorts with only ASs have identified 2p16.1 and 2q22.3 as significant loci and a few genes …

fr, gb (code pays fourni par la source)