Simon Drescher

Call for data: High dose empty liposome control data for a collaborative open access publication (>LIPOTOX<)

Simon Drescher

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Special issue: Phospholipids as functional ingredients in pharmaceutical formulations: Current advances and perspectives

Simon Drescher, Giuseppe De Rosa, Jai Prakash, Félix Sauvage et autres

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Single-chain bolalipids PC-C24-PC and PC-C32-PC: impact on skin permeation and penetration of caffeine ex vivo, structural organization of the stratum corneum and corneocyte morphology

Namarig Abdelrahman, Jakob Josef Schmolz, Jacqueline Schwarzinger, Simon Drescher et autres

Synthetic symmetric single-chain bolalipids (SSCBs) are of interest as new pharmaceutical excipients and might offer new prospects to modulate dermal drug delivery. In contrast to classic anionic surfactants and conventional amphiphilic phospholipids, they have been found to hinder drug penetration of charged …

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Hydrogenated plant-based lecithins as excipients for cosmetic and pharmaceutical applications: A physical-chemical study

Fabio Strati, Simon Drescher, Chen Chao Shen, Reinhard H.H. Neubert

Lecithin is a generic term that is often used to indicate a product mainly constituted of phospholipids. Lecithins can be used in pharmaceutical and cosmetic field as wetting agents, emulsifiers and building blocks for the production of liposomes and micelles. One of …

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The 8th International Symposium on Phospholipids in Pharmaceutical Research – An update on current research in phospholipids presented at the biennial symposium of the Phospholipid Research Center Heidelberg

Simon Drescher, Alfred Blume

This Conference Report recaps recent advances in the research on phospholipids and their applications for advanced drug delivery and analytical purposes that have been presented at the "8th International Symposium on Phospholipids in Pharmaceutical Research" of the Phospholipid Research Center (PRC), held …

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Investigation of keratolytic impact of synthetic bolalipids on skin penetration of a model hydrophilic permeant

Namarig Abdelrahman, Simon Drescher, Lea Ann Dailey, Victoria Klang

Synthetic single-chain bolalipids (SSCBs) are novel excipients in drug delivery, with potential as stabilizers or solubilizers. However, their impact on skin barrier function has not been comprehensively studied. Therefore, two SSCBs (PC-C24-PC and PC-C32-PC) were studied in aqueous systems for their impact …

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The role of phospholipids in drug delivery formulations – Recent advances presented at the Researcher’s Day 2023 Conference of the Phospholipid Research Center Heidelberg

Richard Wibel, Peter van Hoogevest, Simon Drescher

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Azide- and diazirine-modified membrane lipids: Physicochemistry and applicability to study peptide/lipid interactions via cross-linking/mass spectrometry

Patricia Korn, Christian Schwieger, Kai Gruhle, Vasil M. Garamus et autres

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Investigating bolalipids as solubilizing agents for poorly soluble drugs: Effects of alkyl chain length on solubilization and cytotoxicity

Feng Li, Richard D. Harvey, Paola Modicano, Farzad Hamdi et autres

Synthetic single-chain bolalipids with symmetrical headgroups have shown potential in various pharmaceutical applications, such as the stabilization of liposome bilayers. Despite their amphiphilic character, synthetic bolalipids have not yet been investigated for their suitability as solubilizing agents for poorly soluble drug compounds. …

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A Diazirine‐Modified Membrane Lipid to Study Peptide/Lipid Interactions – Chances and Challenges

Julia Dörner, Patricia Korn, Kai Gruhle, Daniel Ramsbeck et autres

Although incorporation of photo-activatable lipids into membranes potentially opens up novel avenues for investigating interactions with proteins, the question of whether diazirine-modified lipids are suitable for such studies, remains under debate. Focusing on the potential for studying lipid/peptide interactions by cross-linking mass …

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The Use of Phospholipids to Make Pharmaceutical Form Line Extensions

Peter van Hoogevest, Harry L.G.M. Tiemessen, Josbert M. Metselaar, Simon Drescher et autres

Abstract This review describes the use of phospholipid excipients to make Pharmaceutical Form (Dosage Form) Line Extensions of existing drugs as part of a Product Life Cycle Management. Product examples and development candidates, which show the versatility of phospholipids as key excipients …

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Influence of a single ether bond on assembly, orientation, and miscibility of phosphocholine lipids at the air–water interface

Matthias H. Hoffmann, Simon Drescher, Christian Schwieger, Dariush Hinderberger

How does a small change in the structure of a phospholipid affect its supramolecular assembly? In aqueous suspensions, the substitution of one ester linkage in DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) by an ether linkage alters its phase behaviour completely. To unravel the effect of replacing …

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