Christian Schwieger

Functional thermodynamics govern the ligand binding to human cytosolic transport proteins

Sebastian Michler, Christian Schwieger, Florian Arndt Schöffmann, Dariush Hinderberger

Traditional binding studies on cellular, molecular transporters often simplify the thermodynamics of binding processes. We present a method that combines spin probing, electron paramagnetic resonance (EPR) spectroscopy and spectral simulations with binding studies and thermodynamics for an in-depth molecular view into ligand …

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Beyond formic acid: Peptides in carpenter ant venoms aid in disease protection

Lukas Koch, Sandro Andreotti, Mario Schubert, Elisa Liebhart et autres

Venom peptides are key to the evolutionary success of most venomous animals, including stinging ants. The stingless ant subfamily Formicinae is thought to rely solely on formic acid in their venoms, despite early, unsubstantiated hints of proteinaceous venom constituents. Here, we show …

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Solution-Borne Protective Carbon Monolayer Coatings

Reuben Jueyuan Yeo, Enzo Bomal, Nicolas Candau, Christopher J.G. Plummer et autres

Carbon nanocoatings have emerged as high-performance solutions for the surface protection of engineering materials, especially in systems containing small precision components. For these applications, it is crucial that the nanocoating be continuous and defect-free even at thicknesses on the order of a …

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Human Peripheral Myelin Protein 2 and Charcot–Marie–Tooth Disease or Structural Missense Variants Show Different Binding to Myelin‐Like Lipid Monolayers

Florian Arndt Schöffmann, Md. Abdus Shukur Imran, Christian Schwieger, Øystein Hetland et autres

The peripheral myelin protein P2 (also known as PMP2/FABP8) has two basic functions in vivo: the transport of fatty acids within the cell to the target compartments and the adhesion of lipid bilayers in the peripheral nervous system myelin to each other. …

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BPS2026 – Functional thermodynamics govern the ligand interactions with human cytosolic transport proteins

Sebastian Michler, Christian Schwieger, Florian Arndt Schoeffmann, Dariush Hinderberger

BPS2026 – Interaction of myelin protein P0ct with myelin-like lipid monolayers at the air-water interface

Elise Johanna Hingst, Christian Schwieger, Dariush Hinderberger

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Human peripheral myelin protein 2 and Charcot-Marie-Tooth disease or structural missense variants show different binding to myelin-like lipid monolayers

Florian Arndt Schöffmann, Md. Abdus Shukur Imran, Christian Schwieger, Øystein Hetland et autres

The peripheral myelin protein P2 (also known as PMP2/FABP8) has two basic functions in vivo: the transport of fatty acids within the cell to the target compartments and the adhesion of lipid bilayers in the peripheral nervous system myelin to each other. …

Beyond formic acid : peptides in carpenter ant venoms aid in disease protection

Lukas Koch, Julian Gatzki, Christian Schwieger, Lydia Kollhoff et autres

Venom peptides are key to the evolutionary success of most venomous animals, including stinging ants. The stingless ant subfamily Formicinae is thought to rely solely on formic acid in their venoms, despite early, unsubstantiated hints of proteinaceous venom constituents. Here, we show …

Competitive adsorption of a monoclonal antibody and amphiphilic polymers to the air–water interface

Elise Johanna Hingst, Michaela Blech, Dariush Hinderberger, Patrick Garidel et autres

Understanding the structure and self-organisation of monoclonal antibodies (mAbs) at the air-water interface is crucial for the stability and efficacy of protein drug formulations. This paper investigates the competitive adsorption of mAb and two amphiphilic polymers, poloxamer 188 (P188) and polysorbate 20 …

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Composite hydrogels of phenylalanine dipeptides with trivalent metal cations

Vanessa Jerschabek, Chife Fidelis, Melissa Kemesies, Jonas Volmer et autres

We studied the co-assembly of hydrogels from a short model peptide, Fmoc-protected diphenylalanine (Fmoc-FF), in the presence of trivalent cations of aluminium (Al) and iron (Fe). Additionally, we investigated the implicit effects of small molecules on the self-assembly of Fmoc-FF by buffering …

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Human Serum Albumin Loaded with Fatty Acids Reveals Complex Protein–Ligand Thermodynamics and Boleadora-Type Solution Dynamics Leading to Gelation

Jörg Reichenwallner, Sebastian Michler, Christian Schwieger, Dariush Hinderberger

High Resolution Image Download MS PowerPoint Slide Using an electron paramagnetic resonance (EPR) spectroscopic strategy that has been developed for core–shell polymers, the complexity of the binding of fatty acids to human serum albumin (HSA) is characterized in detail. We unravel the …

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Effects of Surface Charge of Amphiphilic Peptides on Peptide–Lipid Interactions in the Gas Phase and in Solution

Til Kundlacz, Christian Schwieger, Carla Schmidt

The interactions between peptides and lipids are fundamental for many biological processes. Therefore, exploring the noncovalent interactions that govern these interactions has become increasingly important. Native mass spectrometry is a valuable technique for the characterization of specific peptide-lipid interactions. However, native mass …

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