Accès ouvert
2026
article
OpenAlex
Rika Onishi, Aoi Shiota, Hayato NAKATANI, Masashi Tachibana et autres
Adenovirus (Ad) vectors are a promising next-generation vaccine modality currently under development. An Ad particle is composed of three major capsid proteins—fiber, penton base, and hexon—that play critical roles in cellular entry. However, the extents to which the receptor-mediated cellular entry pathways …
jp, fr
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Accès ouvert
2024
article
OpenAlex
Fuminori Sakurai, Shunsuke Iizuka, Tomohito Tsukamoto, Aoi Shiota et autres
Hemophilia B is an inherited hemorrhagic disorder characterized by a deficiency of blood coagulation factor IX (FIX) that results in abnormal blood coagulation. The blood coagulation is already evident in hemophiliacs at the fetal stage, and thus intracranial hemorrhage and other bleeding …
jp
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Accès ouvert
2024
article
OpenAlex
Rika Onishi, Sena Ikemoto, Aoi Shiota, Tomohito Tsukamoto et autres
Adenovirus (Ad) vectors based on human adenovirus serotype 5 (Ad5) have attracted significant attention as vaccine vectors for infectious diseases. However, the effectiveness of Ad5 vectors as vaccines is often inhibited by the anti-Ad5 neutralizing antibodies retained by many adults. To overcome …
jp
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Accès ouvert
2021
article
OpenAlex
Fuminori Sakurai, Tomohito Tsukamoto, Ryosuke Ono, Fumitaka Nishimae et autres
Replication-incompetent adenovirus (Ad) vectors are promising gene delivery vehicles, especially for hepatocytes, due to their superior hepatic tropism; however, in vivo application of an Ad vector often results in hepatotoxicity, mainly due to the leaky expression of Ad genes from the Ad …
fr, jp
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