Fuminori Sakurai

Corrigendum to “Evaluation of transduction properties and vaccine efficacy of a simian adenovirus type 25-based vector” [European Journal of Pharmaceutical Sciences 225 (2026)107619]

Fuka Okumura, Sora Tokuoka, Naoya Nagata, Rika Onishi et autres

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Adenovirus vector-mediated delivery of the CRISPR-CasRx system enables gene knockdown with suppressed collateral activity

Yuki OSAKADA, Sota Kidawara, Eiko Sakai, Akira Asayama et autres

gene knockdown without evident side effects from collateral activity or Cas13 expression itself in liver.

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Evaluation of transduction properties and vaccine efficacy of a simian adenovirus type 25-based vector

Fuka Okumura, Sora Tokuoka, Naoya Nagata, Rika Onishi et autres

Although human adenovirus serotype 5 (Ad5) is widely used as a vaccine vector for infectious diseases due to its high transduction efficiency, pre-existing immunity to Ad5 in many people reduces vaccine efficacy. To address this limitation, simian Ad vectors, such as ChAdOx1 …

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Effects of cellular receptors on the vaccine efficacies of adenovirus vector-based vaccines following intramuscular and intranasal administration

Rika Onishi, Aoi Shiota, Hayato NAKATANI, Masashi Tachibana et autres

Adenovirus (Ad) vectors are a promising next-generation vaccine modality currently under development. An Ad particle is composed of three major capsid proteins—fiber, penton base, and hexon—that play critical roles in cellular entry. However, the extents to which the receptor-mediated cellular entry pathways …

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Efficacy of intranasal adenovirus vector vaccine is attenuated by type I IFN-induced NK cell activation

Hayato NAKATANI, Masashi Tachibana, Rika Onishi, Takato Nakagaki et autres

Adv vaccination. Our findings contribute to the development of more potent and optimized Adv vaccines.

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Liver‐Specific Suppression of PLA2G6 / iPLA 2 β Improves Glucose and Lipid Metabolism in High‐Fat Diet‐Fed Mice

Kahori Shimizu, Mana Nishibata, Katsuyuki Nagata, Sho Hori et autres

β) has been implicated in male fertility, neuronal disorders, and metabolic diseases. However, its therapeutic effects on metabolic disorders remain elusive. We investigated the effects of PLA2G6 suppression on glucose and lipid metabolism. Systemic inhibition of PLA2G6 in high-fat diet-fed mice reduced …

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Association between the Risk of Drug-induced Liver Injury and the Reactive Metabolites Acyl Glucuronides

Atsushi Kawase, Hiroaki Shimada, Fuminori Sakurai

Acyl glucuronides (AG), reactive metabolites formed via the glucuronidation of carboxylic acid-containing drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), are closely associated with drug-induced liver injury (DILI), particularly idiosyncratic types. AG can covalently bind to proteins, potentially disrupting their function and triggering …

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Oncolytic Reovirus-Induced Prostaglandin E2 Production in Human Tumor Cells

Ikuho Ishigami, Hiroaki Shimada, Atsushi Kawase, Hiroyuki Mizuguchi et autres

Oncolytic viruses, which kill tumor cells by tumor cell-specific replication, elicit superior antitumor immunity by efficiently activating the innate immune system. However, innate immunity-mediated inflammation is an undesirable consequence that often induces cellular production of immunosuppressive cellular factors. Among various immunosuppressive cellular …

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Oncolytic adenovirus serotype 35 mediated tumor growth suppression via efficient activation of antitumor immunity

Ryosuke Ono, Sora Tokuoka, Masashi Tachibana, Ken J. Ishii et autres

Background Oncolytic adenoviruses (OAds) mediate superior antitumor effects both by inducing direct oncolysis and activating antitumor immunity. Previously, we developed a novel OAd fully composed of human adenovirus serotype 35 (OAd35). OAd35 efficiently killed a variety of human tumor cells; however, OAd35-mediated …

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Evaluation of the correlation between nuclear localization levels and genome editing efficiencies of Cas12a fused with nuclear localization signals

Tomohito Tsukamoto, Eiko Sakai, Fuminori Sakurai

Genome editing technology using the CRISPR-Cas system is attracting much attention not only as a promising experimental tool for analysis of genome functions, but also as a novel therapeutic approach for genetic disorders. Among the various types of Cas proteins, Cas12a is …

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Transplacental delivery of factor IX Fc-fusion protein ameliorates bleeding phenotype of newborn hemophilia B mice

Fuminori Sakurai, Shunsuke Iizuka, Tomohito Tsukamoto, Aoi Shiota et autres

Hemophilia B is an inherited hemorrhagic disorder characterized by a deficiency of blood coagulation factor IX (FIX) that results in abnormal blood coagulation. The blood coagulation is already evident in hemophiliacs at the fetal stage, and thus intracranial hemorrhage and other bleeding …

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Small extracellular vesicles carrying reovirus, tumor antigens, interferon-β, and damage-associated molecular patterns for efficient tumor treatment

Naomi Shuwari, Chieko Inoue, Ikuho Ishigami, Kentaro Jingushi et autres

Small extracellular vesicles (SEV) have attracted much attention both as mediators of intercellular communication and as drug delivery systems. In addition, recent studies have shown that SEV containing virus components and virus particles are released from virus-infected cells. Oncolytic viruses, which efficiently …

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