Liangjian Liu

Multiscale imaging on proton pump-driven acidity for assessing tumor progression and metastasis

Silüe Zeng, Jingqin Chen, Yaguang Ren, Jianyou Gu et autres

An acidic tumor microenvironment (TME), a hallmark of cancer progression, promotes tumor growth, invasion, and metastasis. Detecting and targeting tumor acidity have emerged as key frontiers in early cancer diagnosis and treatment. However, current approaches lack sensitive and specific methods to visualize …

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Photoacoustic and fluorescence hybrid microscope for cortex-wide imaging of neurovascular dynamics with subcellular resolution

Liangjian Liu, Zhiqiang Xu, Bin Xu, Tao Wu et autres

Simultaneously monitoring cortex-wide microvascular dynamics, blood oxygenation metabolism, and neuronal activities with high spatiotemporal resolution is essential for understanding neurovascular coupling (NVC). However, it remains a challenge for existing neuroimaging tools. Here, we report a linear transducer array-based hybrid microscope (LiTA-HM) that …

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Feng, Qi, Human Freedom and the Values of the True, the Good, and the Beautiful. Trans. by Jeanne Haizhen Allen

Liangjian Liu

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Simultaneous head-mounted imaging of neural and hemodynamic activities at high spatiotemporal resolution in freely behaving mice

Ningbo Chen, Zhiqiang Xu, Zheng Song, Jiuling Liao et autres

Exploring the relationship between neural activity and cerebral hemoglobin-oxygenation responses in freely behaving mice can advance our understanding of neurovascular coupling. Head-mounted microscopes enable neuroimaging in freely behaving mice; however, investigating neurovascular dynamics remains challenging because of a lack of hemodynamic information, …

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From “Talking Idly” to Realizing the Ben Ti of Knowledge and Action: Comments on Lederman’s “What Is the ‘Unity’ in the ‘Unity of Knowledge and Action’?”

Liangjian Liu

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NIR‐II Photoacoustic Imaging‐Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma

Silüe Zeng, Jingqin Chen, Rongkang Gao, Rui Chen et autres

Abstract Hypoxia, a prominent hallmark of hepatocellular carcinoma (HCC), undermines curative outcomes, elevates recurrence rates, and fosters metastasis, particularly during photodynamic therapy (PDT) in clinical settings. Studies indicate that alleviating tumor hypoxia enhances PDT efficacy. However, persistent challenges, including suboptimal oxygen delivery …

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Restoring the imaging quality of circular transducer array-based PACT using synthetic aperture focusing technique integrated with 2nd-derivative-based back projection scheme

Rongkang Gao, Tao Chen, Yaguang Ren, Liangjian Liu et autres

Circular-array-based photoacoustic computed tomography (CA-PACT) is a promising imaging tool owing to its broad acoustic detection coverage and fidelity. However, CA-PACT suffers from poor image quality outside the focal zone along both elevational and lateral dimensions. To address this challenge, we proposed …

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Handheld photoacoustic imaging of indocyanine green clearance for real-time quantitative evaluation of liver reserve function

Hai Zhang, Silüe Zeng, Yunzhu Wu, Ruoxin Zhang et autres

Preoperative assessment of liver function reserve (LFR) is essential for determining the extent of liver resection and predicting the prognosis of patients with liver disease. In this paper, we present a real-time, handheld photoacoustic imaging (PAI) system-based noninvasive approach for rapid LFR …

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Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging

Zong Chang, Liangjian Liu, Jingying Zhai, Chenchen Liu et autres

Molecular electronic coupling has been found to play a crucial role in the light-induced processes of natural and artificial systems. The light-induced acoustic process (photoacoustic) is also considered to be one of the most essential characters of the light-absorbing molecules. Herein, we …

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Mencius and Wang Fuzhi

Liangjian Liu

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Photoacoustic image-guided biomimetic nanoparticles targeting rheumatoid arthritis

Jianhai Chen, Silüe Zeng, Qiang Xue, Yuchuan Hong et autres

The high level of reactive oxygen species (ROS) in the rheumatoid arthritis (RA) microenvironment (RAM) and its persistent inflammatory nature can promote damage to joints, bones, and the synovium. Targeting strategies that integrate effective RAM regulation with imaging-based monitoring could lead to …

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Depth-extended acoustic-resolution photoacoustic microscopy based on a two-stage deep learning network

Jing Meng, Xueting Zhang, Liangjian Liu, Silüe Zeng et autres

Acoustic resolution photoacoustic microscopy (AR-PAM) is a major modality of photoacoustic imaging. It can non-invasively provide high-resolution morphological and functional information about biological tissues. However, the image quality of AR-PAM degrades rapidly when the targets move far away from the focus. Although …

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