2025
article
OpenAlex
Qilong Jiang, Xinmiao Wei, Xiaojing Pan, Xiao Yan et autres
Regulatory mechanisms underlying microglia-dependent restorative effects during the early stages following spinal cord injury (SCI) remain uncertain. In adult mice, microglia depletion exacerbates injury and impairs functional recovery, suggesting that microglia play a protective role after SCI. We performed RNA sequencing on …
cn
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Accès ouvert
2025
article
OpenAlex
Li Xu, Jixing Zhang, Yinsong Wang, Dong Liu et autres
The evolutionarily conserved nucleosome assembly protein 1 (NAP1) functions as a histone chaperone for H2A-H2B, regulating nucleosome assembly and maintaining chromatin integrity. However, the dynamic and variable nature of the interactions between acidic NAP1 and basic H2A-H2B has obscured the molecular basis …
cn
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Accès ouvert
2025
article
OpenAlex
Nonghua Lv, Peng Chen, Xiaobin Dai, Hu Xu et autres
Abstract Mechanistic studies of viral neutralization typically prioritize high‐affinity antibodies, relegating low‐affinity binders to the sidelines. P5‑1C8, a Class 1 SARS‐CoV‐2 antibody that exemplifies this underexplored “low‑affinity yet high‑potency” phenotype is reported, retaining strong neutralization of Omicron JN.1 despite markedly weakened trimer …
cn, us, kr, hk, Éthiopie
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Accès ouvert
2025
preprint
OpenAlex
Nonghua Lv, Peng Chen, Xiaobin Dai, Hu Xu et autres
Mechanistic studies of viral neutralization typically prioritize high-affinity antibodies, relegating low-affinity binders to the sidelines. We report P5-1C8, a Class 1 SARS-CoV-2 antibody that exemplifies this underexplored “low-affinity yet high-potency” phenotype, retaining strong neutralization of Omicron JN.1 despite markedly weakened trimer binding …
cn, us, kr, hk
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Accès ouvert
2025
preprint
OpenAlex
Ge Liao, Ruolan Sun, Zilin Shen, Zhiteng Luo et autres
The functional diversification of biosynthetic enzymes underlies the chemical richness of natural products, yet how primary metabolic enzymes evolve to acquire specialized functions in secondary metabolism remains elusive. Here, we report a tripartite enzyme complex from oral Streptococcus species—comprising 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase …
cn, hk
(code pays fourni par la source)
2025
preprint
OpenAlex
Ge Liao, Ruolan Sun, Zilin Shen, Zhiteng Luo et autres
The functional diversification of biosynthetic enzymes underlies the chemical richness of natural products, yet how primary metabolic enzymes evolve to acquire specialized functions in secondary metabolism remains elusive. Here, we report a tripartite enzyme complex from oral Streptococcus species—comprising 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase …
cn, hk
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Zefeng Yang, Jinkun Liu, Chengjie Huang, Xiaoming Zhu et autres
PURPOSE: To evaluate the impact of prolonged use of topical glaucoma medications on the surgical outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in juvenile open-angle glaucoma (JOAG). PATIENTS AND METHODS: This multicenter retrospective study included 100 eyes of 77 JOAG patients who underwent …
cn
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Accès ouvert
2025
review
OpenAlex
Zhixuan Wang, Hongyang Zhang, Yuhan Feng, Xiaojing Pan et autres
BACKGROUND: Juvenile-onset open-angle glaucoma (JOAG) is a rare and refractory form of glaucoma, primarily characterized by structural abnormalities in the trabecular meshwork and Schlemm's canal. These abnormalities disrupt aqueous humor outflow, resulting in elevated intraocular pressure and progressive glaucomatous damage. Pharmacological and …
cn
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2025
article
OpenAlex
Ying Su, Haoyun Duan, Dulei Zou, Chunxiao Dong et autres
Primary open-angle glaucoma is a prevalent type of degenerative eye disease that results in lifelong blindness, and its critical pathogenic cause is trabecular meshwork (TM) dysfunction or decreased TM cellularity. Considering that TM develops from neural crest cells (NCCs), we investigate the …
cn
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Accès ouvert
2025
article
OpenAlex
Qi Jiang, Xiaojing Pan, Tengbo Yu, Xinmiao Wei et autres
Spinal cord injury (SCI) remains a significant therapeutic challenge, lacking effective treatment options. Related studies have found that neonatal microglia are more effective than adult microglia in promoting the recovery of SCI, but the reason why neonatal, not adult, microglia are more …
cn
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Accès ouvert
2025
article
OpenAlex
Xinlei Zhu, Benxiang Qi, Lin William Cong, Xiaojing Pan et autres
Purpose: The purpose of this study was to evaluate the neuroprotective effects of delivering nerve growth factor (NGF) to retinal ganglion cells (RGCs) through adeno-associated virus serotype 2 (AAV2) carrying a neuronal-specific human synapsin (hSyn) promoter. Methods: AAV2-hSyn-NGF was injected intravitreally in …
cn
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2025
article
OpenAlex
Zefeng Yang, Zhixuan Wang, Hanying Fan, Qingshu Ge et autres
PRÉCIS: 240-degree and 360-degree goniotomy (GT) demonstrated similar efficacy in intraocular pressure (IOP) reduction, both outperforming 120-degree GT in patients with juvenile open angle glaucoma (JOAG) at postoperative 6-month follow-up. OBJECTIVE: To compare the surgical efficacy and safety of 120-degree, 240-degree, and …
cn, us, hk
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