Patrick J. Cahill

A changing early onset scoliosis phenotype in spinal muscular atrophy: nusinersen treatment is associated with younger age, increased curve magnitude, and kyphosis at the time of index surgery

Ian Hollyer, Talissa Oliveira Generoso, Bill Young, Xochitl M. Bryson et autres

BACKGROUND: Nusinersen provides functional benefits to Spinal Muscular Atrophy (SMA) patients but does not affect the prevalence or progression of scoliosis. This study aims to characterize perioperative curve characteristics and patient demographics among patients with SMA undergoing surgical treatment for early onset …

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Letter to the Editor: Editorial: AI-assisted Letters to the Editor—Scope of a Growing Ethical and Practical Concern, and CORR’s Approach to Managing It

Patrick J. Cahill, Thomas A. Coleman, Samantha Gogel

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Variability in the association between angle of trunk rotation and Cobb angle based on demographic factors

Rayyan Abid, Abigail E. Manning, Patrick J. Cahill, Baron S.H. Lonner et autres

INTRODUCTION: AIS is a 3D deformity characterized by vertebral body rotation, often quantified by the angle of trunk rotation (ATR). However, there is not necessarily a linear relationship between ATR and Cobb angle. We aimed to examine demographic factors that affect this …

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Intraoperative neuromonitoring alerts during surgery for congenital spinal deformity: prevalence, risk factors, and outcomes in a prospective study of 100 patients

Anuj Gupta, Brett A. Shannon, Munish C Gupta, Petya K. Yorgova et autres

BACKGROUND: Surgical goals for congenital spinal deformity (CSD) include correction of deformity and prevention of progression without affecting neurological function. CSD has a higher incidence of intraoperative neuromonitoring (IONM) alerts than other scoliosis types and a potential for risk of postoperative neurological …

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Correction: A comparison of patients with adolescent idiopathic scoliosis and Lenke C-type lumbar curves treated with selective thoracic fusion vs non-selective fusion: a 10-year follow-up study

Nicholas D. Fletcher, Tracey P. Bryan, Suken A. Shah, Stefan Parent et autres

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Estimating pediatric lung volumetric parameters via rapid, limited‐slice, free‐breathing thoracic dynamic MRI

You Hao, Yubing Tong, Caiyun Wu, Joseph M. McDonough et autres

BACKGROUND: Dynamic, separate lung volume assessment during breathing is critical for evaluating thoracic disorders like scoliosis, thoracic insufficiency syndrome (TIS), and pulmonary diseases, as well as for monitoring treatments. While traditional volumetric assessment relies on static 3D imaging during breath-holds, this is …

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Lumbar curve correction is durable at 5 years after thoracic fusion in patients with open triradiate cartilage: a cohort comparison to mature patients

Scott Yang, Bailey Ingalls, Tracey P. Bryan, Jennifer M. Bauer et autres

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Outcomes of Spinal Deformity Treatment in Asphyxiating Thoracic Dystrophy

Katerina M. Kourpas, John W. Stelzer, Jacob Jordan, Blake K. Montgomery et autres

BACKGROUND: Asphyxiating thoracic dystrophy (ATD), or Jeune syndrome, is a rare skeletal dysplasia marked by a severe hypoplastic chest wall and restrictive lung disease, leading to an often-lethal thoracic insufficiency syndrome. Early-onset scoliosis (EOS) can complicate ATD, but details of operative management …

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Twenty-Five Years of Global Private Investment in Pediatric Orthopaedic Start-ups

Jacob Jordan, Jason Brett Anari, Patrick J. Cahill, John Younger

BACKGROUND: New drugs, devices, and other tools are essential to improving children's orthopaedic care. An often underappreciated aspect of new products is the amount of time and money needed to bring them to the bedside. While grants and other seed money have …

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Tether Breakage Across First-generation and Second-generation Vertebral Body Tethering Devices in Treating Adolescent Idiopathic Scoliosis

Thomas A. Coleman, Andrew Kim, Vineet Desai, Stefan Parent et autres

BACKGROUND: Tether breakage is a significant complication that can occur when performing vertebral body tethering (VBT) in patients with adolescent idiopathic scoliosis (AIS). While previous studies have reported tether breakage rates, the incidence of tether breakage across medical device manufacturers and VBT …

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A comparison of patients with adolescent idiopathic scoliosis and Lenke C-type lumbar curves treated with selective thoracic fusion vs non-selective fusion: a 10-year follow-up study

Nicholas D. Fletcher, Tracey P. Bryan, Suken A. Shah, Stefan Parent et autres

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A History of US Medical Device Regulation and Current Regulatory Framework

Jacob M. Gluski, Max Ward, David W. Polly, Kali R. Tileston et autres

» The Food and Drug Administration (FDA) was created in the wake of public outcry generated by Upton Sinclair's The Jungle. The FDA gained further regulatory authority following successive public health setbacks in the 20th century. » A full review for a …

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