Konstantin Pusl

Clinical presentation of neurosyphilis – a single-center retrospective data analysis

Susanne Dyckhoff-Shen, Ilias Masouris, Stefanie Völk, Konstantin Pusl et autres

BACKGROUND: As cases of neurosyphilis are rising worldwide - especially in people living with HIV (PLWH) - current data on clinical presentation, diagnostics and management of neurosyphilis in Europe are of high interest. METHODS: Clinical data from adult patients, who had been …

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28/w mit Fieber und Kopfschmerzen

Konstantin Pusl, Matthias Klein

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Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication

Yue Ma‐Lauer, Pengyuan Li, Daniela Niemeyer, Anja M. Richter et autres

Introduction: Oxysterol-binding protein (OSBP) is known for its crucial role in lipid transport, facilitating cholesterol exchange between the Golgi apparatus and endoplasmic reticulum membranes. Despite its established function in cellular processes, its involvement in coronavirus replication remains unclear. Methods: In this study, …

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Meningoencephalitis and retinal vasculitis due to rickettsial infection

Louisa Lehner, STEPHAN R. THURAU, Konstantin Pusl, Steffen Tiedt et autres

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Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison

Inge Kroidl, Simon Winter, Raquel Rubio‐Acero, Abhishek Bakuli et autres

BACKGROUND: Measuring specific anti-SARS-CoV-2 antibodies has become one of the main epidemiological tools to survey the ongoing SARS-CoV-2 pandemic, but also vaccination response. The WHO made available a set of well-characterized samples derived from recovered individuals to allow normalization between different quantitative …

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The representative COVID-19 cohort Munich (KoCo19): from the beginning of the pandemic to the Delta virus variant

Ronan Le Gleut, Michael Plank, Peter Pütz, Katja Radon et autres

BACKGROUND: Population-based serological studies allow to estimate prevalence of SARS-CoV-2 infections despite a substantial number of mild or asymptomatic disease courses. This became even more relevant for decision making after vaccination started. The KoCo19 cohort tracks the pandemic progress in the Munich …

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The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 – Results from a prospective cohort of outpatient COVID-19 cases

Kerstin Puchinger, Noemi Castelletti, Raquel Rubio‐Acero, Christof Geldmacher et autres

Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined …

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In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients

Raquel Rubio‐Acero, Noemi Castelletti, Volker Fingerle, Laura Olbrich et autres

Quantitative serological assays detecting response to SARS-CoV-2 are needed to quantify immunity. This study analyzed the performance and correlation of two quantitative anti-S1 assays in oligo-/asymptomatic individuals from a population-based cohort. In total, 362 plasma samples (108 with reverse transcription-polymerase chain reaction …

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