Accès ouvert
2026
article
OpenAlex
Farhan Rahman Chowdhury, M. Ismail Hossain, Muktadir S. Hossain, Tangerul A Jepu et autres
Pneumococcal diseases caused by the human pathogenic bacterium Streptococcus pneumoniae are a major public health concern worldwide. In this study, we examined the pathogenicity of a clinical isolate of S. pneumoniae in the silk moth, Bombyx mori, larvae infection model. The whole …
bd
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Accès ouvert
2025
preprint
OpenAlex
Jacob Pierscianowski, Dustin Duncan, Chunling Blue Lan, Rohit Kholiya et autres
Abstract The metabolic adaptability of intracellular pathogens, such as the Gram-negative Salmonella enterica serovar Typhimurium (STm), enables their survival in nutrient-restricted host environments, while also presenting an opportunity for selective antimicrobial targeting. Herein, we report the synthesis and screening of a small …
ca
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Accès ouvert
2025
article
OpenAlex
Farhan Rahman Chowdhury, Brandon Findlay
BACKGROUND: The prevalence of antibiotic resistance continues to rise, rendering many valuable antimicrobial drugs ineffective. Pairwise cyclic antibiotic therapy, where treatment is rapidly switched between two antibiotics, has been demonstrated in vitro to limit the evolution of antibiotic resistance. However, what happens …
ca
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Accès ouvert
2025
article
OpenAlex
Farhan Rahman Chowdhury, Veronica Banari, Vlada Lesnic, George G. Zhanel et autres
The increasing prevalence of antibiotic resistance is a critical challenge, necessitating the development of strategies to mitigate the evolution of resistance. Collateral sensitivity (CS)-based sequential therapies have been proposed to mitigate resistance evolution. However, the evolutionary repeatability of CS across different experimental …
ca
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Accès ouvert
2025
preprint
OpenAlex
Jacob Pierscianowski, Farhan Rahman Chowdhury, Andréanne Lupien, Brandon Findlay et autres
Abstract Salmonella enterica ser. Typhimurium (STm) is an enteric pathogen that causes almost 100 million cases of salmonellosis a year. A hallmark of STm is their ability to survive and replicate in the macrophages that phagocytose them. Inside the Salmonella -containing vesicles …
ca
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Accès ouvert
2025
article
OpenAlex
Farhan Rahman Chowdhury, Brandon Findlay
Antibiotic resistance threatens to undo many of the advancements of modern medicine. A slow antibiotic development pipeline makes it impossible to outpace bacterial evolution, making alternative strategies essential to combat resistance. In this study, we introduce cyclic antibiotic regimens composed of 3 …
ca
(code pays fourni par la source)
2025
preprint
OpenAlex
Farhan Rahman Chowdhury, Veronica Banari, Vlada Lesnic, George G. Zhanel et autres
Abstract The increasing prevalence of antibiotic resistance is a critical challenge, necessitating the development of strategies to mitigate the evolution of resistance. Collateral sensitivity (CS)-based sequential therapies have been proposed to mitigate resistance evolution. However, the evolutionary repeatability of CS across different …
ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Farhan Rahman Chowdhury, Laura Domínguez Mercado, Katya Kharitonov, Brandon Findlay
as well as the challenging lipopeptide antibiotic polymyxin B. Decreased tridecaptin susceptibility was linked to mutations in outer membrane proteins ompC, lptD and mlaA, with the effect of these genes confirmed through a mix of allelic replacement and knockout studies. Overall, this …
ca
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2025
preprint
OpenAlex
Farhan Rahman Chowdhury, Brandon Findlay
Abstract Antibiotic resistance threatens to undo many of the advancements of modern medicine. A slow antibiotic development pipeline makes it impossible to outpace bacterial evolution, making alternative strategies essential to combat resistance. In this study, we introduce cyclic antibiotic regimens composed of …
ca
(code pays fourni par la source)
2024
preprint
OpenAlex
Farhan Rahman Chowdhury, Laura Domínguez Mercado, Katya Kharitonov, Brandon Findlay
Abstract The rise of antimicrobial resistance as a global health concern has led to a strong interest in compounds able to inhibit the growth of bacteria without detectable levels of resistance evolution. A number of these compounds have been reported in recent …
ca, us
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Accès ouvert
2024
preprint
OpenAlex
Farhan Rahman Chowdhury, Brandon Findlay
Abstract The prevalence of antibiotic resistance continues to rise, rendering many valuable drugs ineffective. Antibiotic cycling regimens that incorporate collateral sensitivity (CS), the phenomenon where resistance to one antibiotic leads to hypersensitivity to another, are hypothesized to slow the evolution of antibiotic …
ca
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Accès ouvert
2024
article
OpenAlex
Sofia Nieves Casillas‐Popova, Nishadi Dilkushi Lokuge, Brandon Andrade‐Gagnon, Farhan Rahman Chowdhury et autres
Recent advances in the treatment of chronic wounds have focused on the development of effective strategies for cutting-edge wound dressings based on nanostructured materials, particularly biocompatible poly(vinyl alcohol) (PVA)-based electro-spun (e-spun) nanofibers. However, PVA nanofibers need to be chemically crosslinked to ensure …
ca
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