Hong Yuan

Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro

Zhanding Cui, Jinyi Liu, Jinlong Wang, Jing Zhang et autres

This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to …

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Epidemiological Study and Genetic Diversity Assessment of Porcine Epidemic Diarrhea Virus (PEDV) in Yunnan Province, China

Pei Zhu, Hong Yuan, Xianghua Shu, Xue Li et autres

Porcine epidemic diarrhea virus (PEDV) is a highly contagious pathogen responsible for devastating enteric disease and lethal watery diarrhea, leading to significant economic losses in the global swine industry. Understanding the epidemiology and genetic diversity of PEDV over the past decade is …

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Enhancement of immune responses to classical swine fever virus E2 in mice by fusion or mixture with the porcine IL-28B

Hong Yuan, Yunjuan Jiao, Jie Gao, Tao Wang et autres

The E2 subunit vaccine has been considered a promising alternative to an attenuated classical swine fever (CSF) vaccine. However, it fails to induce a good cellular immune response. Given that immunogenic adjuvants can regulate the cellular immunity to achieve a maximum efficacy …

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Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV

Pinyi Yang, Xiaoli Wu, Hang Shang, Zixian Sun et autres

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), with a high mortality rate of up to 30%. The envelope glycoproteins of SFTSV, glycoprotein N (Gn) and glycoprotein C (Gc), facilitate …

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High-throughput screening unveils nitazoxanide as a potent PRRSV inhibitor by targeting NMRAL1

Zhanding Cui, Jinyi Liu, Chong Xie, Tao Wang et autres

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) poses a major threat to the global swine industry, yet effective prevention and control measures remain elusive. This study unveils Nitazoxanide (NTZ) as a potent inhibitor of PRRSV both in vitro and in vivo. Through …

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[The Identification Idea of Antibodies Against Ku and Other High-Frequency Antigens].

Feifei Zhang, Jingwei Li, Wei Shen, Yi Fan He et autres

OBJECTIVE: This study was aimed to provide ideas for identifying the antibodies to high-frequency antigens by analyzing a female case of high-frequency antigen antibody (anti-Ku) using serological and sequencing method. METHODS: The methods for identification of blood group, erythrocyte antigen, screening and …

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Caffeic acid phenethyl ester: an effective antiviral agent against porcine reproductive and Respiratory Syndrome Virus

Zhanding Cui, Jing Zhang, Jinlong Wang, Jinyi Liu et autres

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[A method for immortalizing swine monoclonal B cells secreting anti-PRRSV antibodies].

Jian Wang, Jing Zhang, Kun Li, Pu Sun et autres

and then the yielded product was ligated to a vector for retrovirus packaging. The swine lymphocytes immunized with PRRSV were infected the yielded mature viruses and cultured in the complete medium containing CD40L and IL21 cytokines. Then, CD21 was used as the …

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The Rescue and the Selection of the Thermally Stabled Type O Vaccine Candidate Strains of Foot-and-mouth Disease Virus

Dong Li, Ya Gao, Pinghua Li, Xueqing Ma et autres

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