[The Identification Idea of Antibodies Against Ku and Other High-Frequency Antigens].
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Le résumé fourni par la source
OBJECTIVE: This study was aimed to provide ideas for identifying the antibodies to high-frequency antigens by analyzing a female case of high-frequency antigen antibody (anti-Ku) using serological and sequencing method. METHODS: The methods for identification of blood group, erythrocyte antigen, screening and identification of antibody were used to detect the blood type and antibody in the proband. The proband's serum and reagent screening cells treated with Sulfhydryl reagent were applied to judge the type and characteristics of this antibodies when reacted with the regaent screening cells or proband's serum respectively. Gene sequencing was used to determine the genotype of the proband's blood group. RESULTS: . This patient had a rare K0 phenotype. CONCLUSION: The rare Kell-null blood group (also known as K0) were identified by serological and molecular tests in the proband who produced both IgG and IgM type of antibody to high-frequency antigen (anti-Ku). These two methods are of great significance in the identification of this rare blood group as well as the antibody to high frequency antigen.
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Où se fait cette recherche
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Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital pays non établi dans la noticeÉtablissement de santé
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Shanghai Blood Center pays non établi dans la noticeOrganisation à but non lucratif
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Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital Department of Blood Transfusion pays non établi dans la noticeÉtablissement de santé
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Institute of Blood Transfusion pays non établi dans la noticeStructure de recherche
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Shanghai Blood Center et Department of Blood Transfusion — Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, avec 1 autre affiliation.
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