Keaton S. Nahan

Communicating with Stakeholders to Identify High-Impact Research Directions for Non-Targeted Analysis

Sara L. Nason, James P. McCord, Yong-Lai Feng, Jon R. Sobus et autres

Non-targeted analysis (NTA) using high-resolution mass spectrometry without defined chemical targets has the potential to expand and improve chemical monitoring in many fields. Despite rapid advancements within the research community, NTA methods and data remain underutilized by many potential beneficiaries. To better …

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Thermal Extraction: An Alternative Headspace GC–MS Method for Volatile Extractables from Medical Device Materials

Milani Wijeweera Patabandige, Keaton S. Nahan, Joshua A. Young, Berk Öktem et autres

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Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices

Eric M. Sussman, Berk Öktem, Irada S. Isayeva, Jinrong Liu et autres

The developers of medical devices evaluate the biocompatibility of their device prior to FDA’s review and subsequent introduction to the market. Chemical characterization, described in ISO 10993-18:2020, can generate information for toxicological risk assessment and is an alternative approach for addressing some …

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Leveraging Extraction Testing to Predict Patient Exposure to Polymeric Medical Device Leachables Using Physics-based Models

Paul A. Turner, Robert M. Elder, Keaton S. Nahan, Anne Talley et autres

Toxicological risk assessment approaches are increasingly being used in lieu of animal testing to address toxicological concerns associated with release of chemical constituents from polymeric medical device components. These approaches currently rely on in vitro extraction testing in aggressive environments to estimate …

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Screening for extractables in additive-manufactured acrylonitrile butadiene styrene orthopedic cast

Keaton S. Nahan, Eric M. Sussman, Berk Öktem, Lester Schultheis et autres

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The metabolic effects of mercury during the biological cycle of vines (Vitis vinifera)

Adrián Spisso, Ernesto R. Verni, Keaton S. Nahan, Luis Dante Martinez et autres

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Metalloprotein and multielemental content profiling in serum samples from diabetic and hypothyroid persons based on PCA analysis

Ernesto R. Verni, Keaton S. Nahan, Alicia V. Lapiere, Luis Dante Martinez et autres

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Carbon Nanotube Fiber Ionization Mass Spectrometry: A Fundamental Study of a Multi-Walled Carbon Nanotube Functionalized Corona Discharge Pin for Polycyclic Aromatic Hydrocarbons Analysis

Keaton S. Nahan, Noe T. Alvarez, Vesselin N. Shanov, Anne P. Vonderheide

Mass spectrometry continues to tackle many complicated tasks, and ongoing research seeks to simplify its instrumentation as well as sampling. The desorption electrospray ionization (DESI) source was the first ambient ionization source to function without extensive gas requirements and chromatography. Electrospray techniques …

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Determination of Manganese in Whole Blood by Cathodic Stripping Voltammetry with Indium Tin Oxide

Cory A. Rusinek, Wenjing Kang, Keaton S. Nahan, Megan Hawkins et autres

Abstract Manganese (Mn) is a required trace metal in the body. In recent years however, it has garnered significant attention as a developmental neurotoxin in children with chronic exposure. It has been linked to complications such as memory loss with negatively associated …

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The metal and metalloprotein profile of human plasma as biomarkers for stroke diagnosis

Keaton S. Nahan, Kyle B. Walsh, Opeolu M Adeoye, Julio A. Landero Figueroa

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In vivo characterization of magnesium alloy biodegradation using electrochemical H2 monitoring, ICP-MS, and XPS

Daoli Zhao, Tingting Wang, Keaton S. Nahan, Xuefei Guo et autres

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Principal Component Analysis Approach for Determination of Stroke Protein Biomarkers and Modified Atmospheric Pressure Chemical Ionization Source Development for Volatile Analyses

Keaton S. Nahan

always made me feel like a part of the group and that he was the head of the research group family.If I ever had a lousy day, Doc always knew the perfect joke to tell.Some of my favorite moments with Doc were …

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