Sarah Kirsh

Efficacy and Safety of Therapies for Systemic Sclerosis-Associated Interstitial Lung Disease: A Bayesian Network Meta-Analysis

Pei Ye Li, Alex Huynh, Eric Yu, Navjeet Baath et autres

RATIONALE: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is a leading cause of morbidity and mortality in scleroderma. Multiple immunomodulatory and antifibrotic therapies have been evaluated, but their comparative effectiveness remains uncertain. METHODS: We conducted a systematic review and Bayesian network meta-analysis of …

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Optimal Duration of Antibiotic Treatment for Group A Streptococcal Pharyngitis in Children: A Systematic Review and Dose-Response Meta-Analysis

Joao Pedro Lima, Mahya Dorri, Michael Ling, Brandon Lee et autres

Background: Group A streptococcal (GAS) pharyngitis drives substantial antibiotic prescribing in children. The 10-day standard burdens adherence and prolongs exposure, increasing selective pressure for resistance. Yet, whether shorter courses achieve comparable outcomes remains unresolved. Purpose: To address how the duration of oral …

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The acute adverse health effects of kratom: an evaluation of case reports

Sarah Smallets, Sydney Litvin, Grayson Abele, Sarah Kirsh et autres

, commonly known as kratom, has gained popularity in the United States due to its stimulant and analgesic effects. Allegations of kratom-associated adverse health effects, primarily based on case reports/series, have obtained media attention. Thus, a systematic literature search using PubMed was …

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Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis

Dena Zeraatkar, Sumanth Kumbargere Nagraj, Tanvir Jassal, Sarah Kirsh et autres

OBJECTIVE: To review evidence from randomised trials assessing the effectiveness of strategies to deprescribe benzodiazepines and closely related sedative hypnotics (BSH). DESIGN: Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES: MEDLINE, Embase, CINAHL, PsycInfo, and CENTRAL, searched from inception to …

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The value of a life course approach to the health consequences of climate change

Elisabeth M. Simonin, Sotheany R. Leap, Eleanor Klibaner-Schiff, Sarah Kirsh et autres

Abstract Climate change, initiated by the Industrial Revolution, has resulted in a warming planet with increased extreme weather events. In addition, pollutant exposures are rapidly increasing. Exposures to both extreme weather and pollution have direct and indirect negative impacts on health. While …

Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis

Dena Zeraatkar, Sarah Kirsh, Tanvir Jassal, Tyler Pitre et autres

BACKGROUND: Up to 15% of survivors of COVID-19 infection experience long-term health effects, including fatigue, myalgia and impaired cognitive function, termed post-COVID-19 condition or long COVID. Several trials that study the benefits and harms of various interventions to manage long COVID have …

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Interventions for the management of long covid (post-covid condition): living systematic review

Dena Zeraatkar, Sarah Kirsh, Tanvir Jassal, Mahnoor Shahab et autres

OBJECTIVE: To compare the effectiveness of interventions for the management of long covid (post-covid condition). DESIGN: Living systematic review. DATA SOURCES: Medline, Embase, CINAHL, PsycInfo, Allied and Complementary Medicine Database, and Cochrane Central Register of Controlled Trials from inception to December 2023. …

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Environmental exposures influence multigenerational epigenetic transmission

Eleanor Klibaner-Schiff, Elisabeth M. Simonin, Cezmi A. Akdiş, Ana Cheong et autres

Epigenetic modifications control gene expression and are essential for turning genes on and off to regulate and maintain differentiated cell types. Epigenetics are also modified by a multitude of environmental exposures, including diet and pollutants, allowing an individual's environment to influence gene …

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Proactive therapeutic drug monitoring of biologic drugs in patients with inflammatory bowel disease, inflammatory arthritis, and psoriasis: systematic review and meta-analysis

Dena Zeraatkar, Tyler Pitre, Sarah Kirsh, Tanvir Jassal et autres

Objective: To address the efficacy and safety of proactive therapeutic drug monitoring of biologic drugs for patients with inflammatory bowel disease, inflammatory arthritis, and psoriasis. Design: Systematic review and meta-analysis. Data sources: Medline, Embase, Central, and CINAHL, from database inception to 23 …

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Values and preferences in COVID-19 public health guidelines: a systematic review

Sarah Kirsh, Tanvir Jassal, Tyler Pitre, Thomas Piggott et autres

BACKGROUND: Internationally accepted standards for trustworthy guidelines include the necessity to ground recommendations in values and preferences. Considering values and preferences respects the rights of citizens to participate in health decision-making and ensures that guidelines align with the needs and priorities of …

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Challenges in Appraising Nutrition Evidence: A Scoping Review

Dena Zeraatkar, Sarah Kirsh, Tyler Pitre, Tanvir Jassal

assessment of FFA flux in Alb -/-and WT mice of both sexes by using the procedure above.Results: The mice showed no signs of distress or acute illness following the injection of PVP/DMSO or albumin formulations.Hematocrit, serum FFA flux rate, and FFA concentration …

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Values and preferences in COVID-19 public health guidelines: A systematic review

Sarah Kirsh, Tanvir Jassal, Tyler Pitre, Thomas Pigott et autres

Abstract Background Internationally accepted standards for trustworthy guidelines include the necessity to ground recommendations in values and preferences. Considering values and preferences respects the rights of citizens to participate in health decision-making and ensures that guidelines align with the needs and priorities …

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