Western Diet-Induced Nonalcoholic Fatty Liver Disease Mice Mimic the Key Transcriptomic Signatures Observed in Humans
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Le résumé fourni par la source
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption or a secondary cause of hepatic steatosis. The prevalence of NAFLD is increasing worldwide and its management has become a public health concern. Animal models are traditionally used to elucidate disease mechanisms and identify potential drug targets; however, their translational aspects in human diseases have not been fully established. This study aimed to clarify the utility of animal models for translational research by assessing their relevance to human diseases using gene expression analysis. Weighted gene co-expression network analysis of liver tissues from Western diet (WD)-induced NAFLD mice was performed to identify the modules associated with disease progression. Moreover, the similarity of the gene co-expression network across species was evaluated using module preservation analysis. Nineteen disease-associated modules were identified. The brown module was positively associated with disease severity, and functional analyses indicated that it may be involved in inflammatory responses in immune cells. Moreover, the gene co-expression network of the brown module was highly preserved in human NAFLD liver gene expression datasets. These results indicate that WD-induced NAFLD mice have similar gene co-expression networks (especially genes associated with inflammatory responses) to humans and are thought to be a useful experimental tool for preclinical research on NAFLD. Keywords: Nonalcoholic fatty liver disease (NAFLD), Weighted gene co-expression network analysis (WGCNA), Western diet (WD).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Western Diet-Induced Nonalcoholic Fatty Liver Disease Mice Mimic the Key Transcriptomic Signatures Observed in Humans
- Date Crossref
- 31/08/2024
- Éditeur
- Institute of Physiology of the Czech Academy of Sciences
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Japan Tobacco (United States) pays non établi dans la noticeEntreprise
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Kyoto University pays non établi dans la noticeUniversité ou école supérieure
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Japan Tobacco (Japan) pays non établi dans la noticeEntreprise
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Tokyo University of Agriculture pays non établi dans la noticeUniversité ou école supérieure
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Takatsuki Research Center Biological/Pharmacological Research Laboratories pays non établi dans la noticeStructure de recherche
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Graduate School of Agriculture Laboratory of Animal Physiology and Functional Anatomy pays non établi dans la noticeUniversité ou école supérieure
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Yokohama Research Center i2i Labo pays non établi dans la noticeStructure de recherche
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Prague pays non établi dans la noticeInstitution
Japan Tobacco (United States), Kyoto University et Japan Tobacco (Japan), avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.