Simon Ekström

Effect of User-Prompted Priors on Semi-Automated Cancer Lesion Segmentation in Whole-Body Computed Tomography

Isac Stark, Johan Öfverstedt, Elin Lundström, Simon Ekström et autres

In clinical oncology studies, metastatic cancer is commonly evaluated using "Response Evaluation Criteria in Solid Tumors" (RECIST), in which the diameter of up to five lesions is measured and followed over the course of treatment. However, RECIST shows limited correlation with overall …

Effect of User-Prompted Priors on Semi-Automated Cancer Lesion Segmentation in Whole-Body Computed Tomography

Isac Stark, Johan Öfverstedt, Elin Lundström, Simon Ekström et autres

In clinical oncology studies, metastatic cancer is commonly evaluated using "Response Evaluation Criteria in Solid Tumors" (RECIST), in which the diameter of up to five lesions is measured and followed over the course of treatment. However, RECIST shows limited correlation with overall …

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Material Culture in the Swedish Navy, c. 1450-1850

Simon Ekström, Niklas Eriksson, Anna Forssberg, Leos Müller

Regulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15

Carmen Ebenwaldner, Antonio Ginés García Saura, Simon Ekström, Katja Bernfur et autres

Abstract PARP15 is a mono-ADP-ribosyltransferase that targets an unknown set of proteins as well as RNA. Its evolutionary relationship with PARP14 suggests roles in antiviral defence; its localization to stress granules points to functions in the regulation of translation. Here we show …

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Accessing the proteome of extracellular vesicles via rapid acoustic isolation of a minute human blood plasma sample

Megan Havers, Aaron Scott, Niklas Ortenlöf, Charlotte Welinder et autres

Despite substantial progress in the field of mass spectrometry, there remain barriers to measuring the extracellular vesicles (EVs) proteome in blood plasma. Recent work has shown that isolating EVs can make it possible to detect proteins that have low abundance in plasma. …

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Streptococcus pyogenes nuclease A interferes with host complement functions

Isabella Andersson Bennig, Joel Ströbaek, Rafael Mamede, Ariane Neumann et autres

ABSTRACT Bacterial pathogens deploy diverse virulence factors to subvert host immunity, yet the molecular details of these interactions often remain unresolved. Here, we investigate the structure and host interactome of the Streptococcus pyogenes nuclease A (SpnA). We characterized the structure and dynamics …

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Tissue-specific and whole-body insulin sensitivity by integrated imaging and hyperinsulinemic euglycemic clamp: A repeatability study in people with T2DM and overweight/obesity

Iina Laitinen, Helena Litorp, Folke Sjöberg, Simon Ekström et autres

Assessment of glucose uptake by PET imaging under hyperinsulinemic euglycemic clamp (HEC) is an insightful tool for quantification of insulin resistance, a hallmark of diabetes and an area of interest in drug development. To enable the use of the method in metabolic …

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Nucleotide Binding to the ATP-cone in Anaerobic Ribonucleotide Reductases Allosterically Regulates Activity by Modulating Substrate Binding

Ornella Bimaï, Ipsita A. Banerjee, Inna Rozman Grinberg, Ping Huang et autres

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Design of a Streptolysin O Epitope-Centric Nanoparticle Vaccine Against Streptococcus pyogenes

Di Tang, Yashuan Chao, Elisabeth Hjortswang, Joel Ströbaek et autres

Abstract Streptococcus pyogenes (Group A Streptococcus , GAS) is a significant human pathogen for which no licensed vaccine is currently available. Here, we report a de novo designed epitope-centric protein-based nanoparticle vaccine against GAS. By integrating structural mass spectrometry techniques and deep …

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Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow

Alejandro Gómez Toledo, Sounak Chowdhury, Elisabeth Hjortswang, James T. Sorrentino et autres

This study showcases an integrative mass spectrometry-based strategy combining systems antigenomics and systems serology to characterize human antibodies in clinical samples. This strategy involves using antibodies circulating in plasma to affinity-enrich antigenic proteins in biochemically fractionated pools of bacterial proteins, followed by …

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Streptolysin O accelerates the conversion of plasminogen to plasmin

Di Tang, Hamed Khakzad, Elisabeth Hjortswang, Lars Malmström et autres

Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host. In this study, we use affinity-enrichment mass spectrometry to decipher the host-pathogen …

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Author response: Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding

Ornella Bimaï, Ipsita A. Banerjee, Inna Rozman Grinberg, Ping Huang et autres

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