Laura L.A. van Dijk

Host-directed iminosugars MON-DNJ and NB-DNJ inhibit measles virus and human respiratory syncytial virus replication in vitro

Laura L.A. van Dijk, Katharina S. Schmitz, Matteo N. Barbaglia, Andrea Magrì et autres

Measles virus (MeV) and human respiratory syncytial virus (HRSV) remain significant causes of global morbidity and mortality; measles in unvaccinated children, HRSV in infants below 6 months, immunocompromised, and the elderly. Despite the availability of vaccines and prophylactic monoclonal antibodies, there is …

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Innate airway responses shape permissiveness to human respiratory syncytial virus

Laura L.A. van Dijk, Laurine C. Rijsbergen, Alexander C. Havelaar, Yvette den Hartog et autres

The interaction between human respiratory syncytial virus (HRSV) and the innate immune system has been demonstrated both in vitro and in vivo. Disruption of interferon (IFN) signaling pathways increases susceptibility and permissiveness to HRSV infection, whereas pretreatment of cells with IFN confers …

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Paramyxovirus infection driven by heteromultivalent sialoglycotope binding

Xuesheng Wu, Mengying Liu, Laura Blekkenhorst, Mare H. L. Verbruggen et autres

Sialic acids (Sia) on glycoproteins and glycosphingolipids act as receptors for many respiratory viruses, including human influenza A viruses and respiroviruses, which typically bind to α2-6- and α2-3-linked Sia (2-6Sia and 2-3Sia), respectively. In view of this binding discrepancy and as the …

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Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters

Kim Handrejk, Katharina S. Schmitz, Edwin J. B. Veldhuis Kroeze, Laura L.A. van Dijk et autres

As SARS-CoV-2 continues to evolve antigenically to escape vaccine- or infection-induced immunity, suitable animal models are needed to study novel interventions against viral variants. Syrian hamsters are often used because of their high susceptibility to SARS-CoV-2 and associated tissue damage in the …

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mRNA-based COVID-19 vaccination of lung transplant recipients with prior SARS-CoV-2 infection induces durable SARS-CoV-2-specific antibodies and T cells

Siqi Liu, Laura L.A. van Dijk, Yvette den Hartog, Rogier A.S. Hoek et autres

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Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters

Kim Handrejk, Katharina S. Schmitz, Edwin J. B. Veldhuis Kroeze, Laura L.A. van Dijk et autres

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Virus neutralization assays for human respiratory syncytial virus using airway organoids

Laura L.A. van Dijk, Laurine C. Rijsbergen, Bruno Tello Rubio, Katharina S. Schmitz et autres

Neutralizing antibodies are considered a correlate of protection against severe human respiratory syncytial virus (HRSV) disease. Currently, HRSV neutralization assays are performed on immortalized cell lines like Vero or A549 cells. It is known that assays on these cell lines exclusively detect …

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SARS-CoV-2-specific immune responses converge in kidney disease patients and controls with hybrid immunity

Muriel Aguilar-Bretones, Yvette den Hartog, Laura L.A. van Dijk, S. Reshwan K. Malahe et autres

Healthy individuals with hybrid immunity, due to a SARS-CoV-2 infection prior to first vaccination, have stronger immune responses compared to those who were exclusively vaccinated. However, little is known about the characteristics of antibody, B- and T-cell responses in kidney disease patients …

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Original COVID-19 priming regimen impacts the immunogenicity of bivalent BA.1 and BA.5 boosters

Luca M. Zaeck, Ngoc H. Tan, Wim J. R. Rietdijk, Daryl Geers et autres

Waning antibody responses after COVID-19 vaccination combined with the emergence of the SARS-CoV-2 Omicron lineage led to reduced vaccine effectiveness. As a countermeasure, bivalent mRNA-based booster vaccines encoding the ancestral spike protein in combination with that of Omicron BA.1 or BA.5 were …

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Distinct COVID-19 vaccine combinations result in divergent immune responses

Luca M. Zaeck, Ngoc H. Tan, Wim J. R. Rietdijk, Daryl Geers et autres

Summary Waning antibody responses after COVID-19 vaccination combined with the emergence of the SARS-CoV-2 Omicron lineage led to reduced vaccine effectiveness. As a countermeasure, bivalent mRNA-based booster vaccines encoding the ancestral spike protein in combination with that of Omicron BA.1 or BA.5 …

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The role of interleukin-21 in COVID-19 vaccine–induced B cell–mediated immune responses in patients with kidney disease and kidney transplant recipients

S. Reshwan K. Malahe, Yvette den Hartog, Wim J. R. Rietdijk, Debbie van Baarle et autres

T-cell-mediated help to B cells is required for the development of humoral responses, in which the cytokine interleukin (IL)-21 is key. Here, we studied the mRNA-1273 vaccine-induced SARS-CoV-2-specific memory T-cell IL-21 response, memory B cell response, and immunoglobulin (Ig)G antibody levels in …

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Immunogenicity of bivalent omicron (BA.1) booster vaccination after different priming regimens in health-care workers in the Netherlands (SWITCH ON): results from the direct boost group of an open-label, multicentre, randomised controlled trial

Ngoc H. Tan, Daryl Geers, Roos S. G. Sablerolles, Wim J. R. Rietdijk et autres

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