Accès ouvert
2021
article
OpenAlex
Michael J. Boyd, Philip N. Collier, Michael P. Clark, Hongbo Deng et autres
In our efforts to identify novel small molecule inhibitors for the treatment of adrenoleukodystrophy (ALD), we conducted a high-throughput radiometric screen for inhibitors of elongation of very long chain fatty acid 1 (ELOVL1) enzyme. We developed a series of highly potent, central …
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Accès ouvert
2016
article
OpenAlex
John J. Court, Carl Poisson, Andrzej Ardzinski, Darius Bilimoria et autres
The hepatitis C viral proteins NS3/4A protease, NS5B polymerase, and NS5A are clinically validated targets for direct-acting antiviral therapies. The NS5B polymerase may be inhibited directly through the action of nucleosides or nucleotide analogues or allosterically at a number of well-defined sites. …
us, ca
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Accès ouvert
2015
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OpenAlex
Hardwin O’Dowd, Dean E. Shannon, Kishan R. Chandupatla, Vaishali S. Dixit et autres
Benzimidazole 1 is the lead compound resulting from an antibacterial program targeting dual inhibitors of bacterial DNA gyrase and topoisomerase IV. With the goal of improving key drug-like properties, namely, the solubility and the formulability of 1, an effort to identify prodrugs …
us, ca
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2004
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Rhett T. Watson, Vinayak K. Gore, Kishan R. Chandupatla, R. Karl Dieter et autres
Abstract For Abstract see ChemInform Abstract in Full Text.
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2004
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R. Karl Dieter, Gabriel Oba, Kishan R. Chandupatla, Chris M. Topping et autres
Abstract For Abstract see ChemInform Abstract in Full Text.
us
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2004
article
OpenAlex
Rhett T. Watson, Vinayak K. Gore, Kishan R. Chandupatla, R. Karl Dieter et autres
The asymmetric synthesis of (-)-(R)-pyrrolam A was achieved in three operations from N-Boc pyrrolidine via an alpha-(N-carbamoyl)alkylcuprate vinylation reaction followed by N-Boc deprotection and cyclization. One-pot deprotection-cyclization procedures led to mixtures of pyrrolam A and its double bond isomers. These isomerization events …
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2004
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OpenAlex
R. Karl Dieter, Gabriel Oba, Kishan R. Chandupatla, Chris M. Topping et autres
Stereogenic 2-(N-carbamoyl)pyrrolidinylcuprates prepared from scalemic (i.e., enantioenriched) N-Boc-2-lithiopyrrolidine and THF soluble CuCN.2LiCl react with vinyl iodides, vinyl triflates, beta-iodo-alpha,beta-enoates, propargyl mesylates, and allyl bromide to afford the substitution products with excellent enantioselectivity. Excellent enantiomeric ratios are obtained in the conjugate addition reactions …
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2001
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OpenAlex
R. Karl Dieter, Chris M. Topping, Kishan R. Chandupatla, Kai Juan Lu
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article …
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2001
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OpenAlex
R. Karl Dieter, Chris M. Topping, Kishan R. Chandupatla, Kai Juan Lu
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEnantioselectivity in the Reactions of Chiral α-(N-Carbamoyl)alkylcupratesR. Karl Dieter, Chris M. Topping, Kishan R. Chandupatla, and Kai LuView Author Information Howard L. Hunter Laboratory, Department of Chemistry Clemson University, Clemson, South Carolina 29634-0973 Cite this: J. Am. Chem. Soc. …
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