Narjust Florez

The Phase 2b COPERNICUS Study of Subcutaneous Amivantamab with Lazertinib as First-Line Treatment, or with Chemotherapy as Second-Line Treatment, for EGFR-Mutated Non-Small Cell Lung Cancer: a Vodcast

Balázs Halmos, Narjust Florez, Sarah Goldberg, Wade Thomas Iams et autres

INTRODUCTION: In advanced non-small cell lung cancer (NSCLC) with EGFR exon 19 deletions or exon 21 L858R substitution mutations (Ex19del/L858R), intravenous amivantamab is approved for first-line treatment with lazertinib, and second-line treatment with carboplatin-pemetrexed. Subcutaneous amivantamab demonstrated noninferior pharmacokinetics and comparable efficacy …

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Influence of social determinants of health (SDoH) on metastatic non-small cell lung cancer (mNSCLC) testing in the community setting.

Narjust Florez, Lauren Kiel, Lilin Tong, Eileen Farrelly et autres

158 Background: Biomarker testing implementation in community settings remains hindered. We explored the influence of SDoH factors on NGS and PD-L1 testing uptake in patients diagnosed with mNSCLC in the community setting. Methods: Electronic health record data from Florida Cancer Specialists and …

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Exercise referral in oncology among physicians across Latin America.

Paulo Gustavo Bergerot, Cristiane Decat Bergerot, Pamela Muniz, Regina Barragán-Carrillo et autres

483 Background: Exercise is increasingly recognized as a critical component of cancer care, yet its integration into oncology practices varies across regions. In Latin America, data on physicians' perceptions, referral practices, barriers, and facilitators regarding exercise in the oncology setting remain scarce. …

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Assessing the financial implications of translating oncology clinical trial informed consent forms in the U.S.

Shruti Rajesh Patel, Katarina Wang, Ana I. Velazquez Mañana, Narjust Florez et autres

53 Background: Language barriers affect millions in the US, where nearly 8% of individuals (~ 26 million) have limited English proficiency, making it harder to access, understand, and engage with healthcare services. As clinical trials enroll increasingly diverse participants, ensuring the accessibility …

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Clinical strategies for lung cancer management: Recommendations from the Bridging the Gaps Lung Cancer Consensus Conference 2024

Narjust Florez, Sandip Pravin Patel, Heather A. Wakelee, Julia K. Rotow et autres

Clinical practice guidelines for nonsmall cell lung cancer (NSCLC) and small cell lung cancer include recommendations based on high-level clinical trial evidence, but complex clinical questions are frequently seen in real-world practice that are not clearly answered by prospective trial data. To …

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Molecular Therapy and Targeted Treatment for Cancer (with Surgical Lenses)

Narjust Florez, Arthi Sridhar, Lauren Kiel, Angela S. Morabito et autres

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Young lung cancer: from diagnosis to survivorship

Narjust Florez, Lauren Kiel, Rebekah Kaufman, Jaclyn LoPiccolo et autres

Background: Young patients with lung cancer represent a distinct population, with unique disease and treatment-related characteristics, as well as psychosocial and survivorship needs. Nevertheless, this population remains vastly understudied. Methods: We review the unique clinicopathological characteristics and needs of young patients with …

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Clinical outcomes and predictors of response to PD-(L)1 blockade in patients with oncogene-driver negative NSCLC who have never smoked.

Eleonora Gariazzo, Arielle Elkrief, Kyle Concannon, Giulio Metro et autres

8563 Background: Non-small cell lung cancer (NSCLC) in patients (pts) who have never smoked is associated with poor response to immune checkpoint inhibitors (ICI). However, most studies have focused on pts with actionable oncogenes (e.g., EGFR, ALK, ROS1, RET, MET), and it …

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Disparities in exercise referral practices and barriers among oncologists in public and private institutions in Latin America.

Paulo Gustavo Bergerot, Cristiane Decat Bergerot, Pamela Muniz, Maria Natalia Gandur-Quiroga et autres

1629 Background: Exercise offers significant benefit for patients with cancer, improving physical function, quality of life, and treatment-related outcomes. However, barriers such as limited referral practices and insufficient knowledge hinder its integration into care. This study compared referral practices, exercise assessment, and …

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Impact of 2021 United States cancer screening guideline changes on racial and ethnic differences in patient-reported adherence to age-appropriate colorectal cancer screening.

Nishwant S. Swami, Omar Elghawy, Narjust Florez, Edward Christopher Dee

10546 Background: In 2021, the US Preventive Services Task Force and the US Multi-Society Task Force on Colorectal Cancer updated screening guidelines to recommend that average-risk colorectal cancer (CRC) screening should begin at age 45. We used nationally representative survey data to …

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FHINCH study: Fertility and sexual health effects of cancer therapy in young women with lung cancer and melanoma.

Narjust Florez, Lauren Kiel, Courtney Mantz, Kelly Meza et autres

e20081 Background: Recent clinical trials support the efficacy of neoadjuvant and adjuvant immune checkpoint inhibitors (ICIs) or tyrosine kinase inhibitors (TKIs) for patients (pts) with non-small cell lung cancer (NSCLC) and melanoma. Despite broader use and potential adverse events, their impact on …

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Are those all my options? Evaluating oncologists’ communication strategies in treatment and clinical trial discussions by race and gender

Monica Arun Patel, Samantha Vuong, Bonyan A. Qudah, Noelle K. LoConte et autres

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