Young lung cancer: from diagnosis to survivorship
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Le résumé fourni par la source
Background: Young patients with lung cancer represent a distinct population, with unique disease and treatment-related characteristics, as well as psychosocial and survivorship needs. Nevertheless, this population remains vastly understudied. Methods: We review the unique clinicopathological characteristics and needs of young patients with lung cancer, including topics such as incidence rates, diagnostic challenges, genomics, treatment patterns and outcomes, psychosocial needs, fertility and sexual health, and palliative care. We discuss emerging and understudied data, provide recommendations on aspects in which future research is warranted, and advocate for actionable strategies that multi-disciplinary healthcare teams may adopt to provide more personalized and equitable care. Results: Though epidemiological trends suggest an overall decrease in lung cancer incidence among all age groups, recent increasing incidences have been reported among certain young populations in the U.S., as well as among Hispanic women and women in certain European countries. Young patients are significantly more likely to be female or Asian/Pacific Islander, have no tobacco use history, metastasis to the brain, and a higher frequency of somatic mutations or rearrangements. Diagnostic delays pose a considerable concern to young patients with lung cancer and may contribute to how these patients are more likely to be diagnosed with advanced disease than their older counterparts. However, young patients demonstrate improved survival compared to older patients, underscoring the importance of survivorship care. Young patients are more likely to be diagnosed at a disruptive time in their lives, rendering them with distinct psychosocial needs and financial toxicity. Future data on treatment-related effects on fertility and sexual health for young patients is warranted, as is the data related to complementary medicine use. Training in palliative care and promoting a positive attitude towards supportive care is also essential. Conclusions: Young patients with lung cancer represent a distinct patient population, necessitating disease management that is markedly different from that of older patients with lung cancer. Future research, some of which are highlighted by this Review, will aid in elucidating risk factors, survival rates, and clinical, genomic, and histopathological characteristics of young-onset lung cancer to improve screening, early detection, prevention, and treatment of this understudied population.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Young lung cancer: from diagnosis to survivorship
- Date Crossref
- 26/06/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Dana-Farber Cancer Institute Lowe Center for Thoracic Oncology pays non établi dans la noticeStructure de recherche
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Sylvester Comprehensive Cancer Center pays non établi dans la noticeÉtablissement de santé
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Hospital of the University of Pennsylvania Department of Medicine pays non établi dans la noticeÉtablissement de santé
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Illinois College pays non établi dans la noticeUniversité ou école supérieure
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Peoria campus of the University of Illinois System pays non établi dans la noticeUniversité ou école supérieure
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Duke University Duke Cancer Center pays non établi dans la noticeUniversité ou école supérieure
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Duke Medical Center pays non établi dans la noticeÉtablissement de santé
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Southwestern Medical Center Division of Hematology and Oncology pays non établi dans la noticeÉtablissement de santé
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The University of Texas Southwestern Medical Center pays non établi dans la noticeÉtablissement de santé
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Centro de Pesquisas Oncológicas pays non établi dans la noticeStructure de recherche
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Lung Cancer Initiative of North Carolina pays non établi dans la noticeOrganisation à but non lucratif
Harvard University, Lowe Center for Thoracic Oncology — Dana-Farber Cancer Institute et Sylvester Comprehensive Cancer Center, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.