Gabriele Werner‐Felmayer

Das Innsbrucker Handwerkszeug

Barbara Friesenecker, Georg Gasser, R Fantin, Gabriele Werner‐Felmayer et autres

Zusammenfassung Im klinischen Alltag werden Therapieentscheidungen bei komplex erkrankten Hochrisikopatient:innen oft ohne klare argumentative Struktur getroffen und primär an technischer Machbarkeit orientiert, während patientenzentrierte, ethische und rechtliche Aspekte unzureichend berücksichtigt werden. Das Innsbrucker Handwerkszeug bietet hierfür eine einfach memorierbare Vier-Fragen-Struktur , die …

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Psychosomatik - neurobiologisch fundiert und evidenzbasiert

Jennifer L. Steel, Olga Klimecki, Beate Ditzen, Urs M. Nater et autres

Neue Erkenntnisse in der Neuro- und Molekularbiologie, der Epigenetik und Entwicklungspsychologie sowie der Psychotherapie- und der Stressforschung haben zu einem weitreichenden Paradigmenwechsel in der Psychosomatischen Medizin geführt. Dieses Lehr- und Handbuch bietet in 100 Kapiteln zunächst eine aktuelle Bestandsaufnahme der wissenschaftlich gesicherten …

Medical ethical principles against the background of ‘European values’

Markus Frischhut, Gabriele Werner‐Felmayer

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Everyone knows about it, everyone knows how important it is, but the question is always: How?

Martina König‐Bachmann, Pauline Herzog, Heidi Siller, Gabriele Werner‐Felmayer et autres

is an open access and double-blind peer-reviewed scientific journal, that encompasses all aspects of the practice of midwifery, especially focused on midwifery research, support, care and advice during pregnancy, labour and the postpartum period.The overall aim of the journal is to foster, …

Editorial: Data-intensive medicine and healthcare: ethical and social implications in the era of artificial intelligence and automated decision-making

Aviad E. Raz, Jusaku Minari, Silke Schicktanz, Tamar Sharon et autres

Editorial on the Research Topic Data-intensive medicine and healthcare: ethical and social implications in the era of artificial intelligence and automated decision-making Medical "big data" and artificial intelligence (AI) are a hyped duo.Promises include developing more personalised treatments, delegating medical decision-making to …

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Alterations in ether lipid metabolism and the consequences for the mouse lipidome

Katharina Lackner, S. Sailer, Jan‐Bert van Klinken, Eric Wever et autres

Alkylglycerol monooxygenase (AGMO) and plasmanylethanolamine desaturase (PEDS1) are enzymes involved in ether lipid metabolism. While AGMO degrades plasmanyl lipids by oxidative cleavage of the ether bond, PEDS1 exclusively synthesizes a specific subclass of ether lipids, the plasmalogens, by introducing a vinyl ether …

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Psychosocial and bioethical challenges and developments for the future of vascularized composite allotransplantation: A scoping review and viewpoint of recent developments and clinical experiences in the field of vascularized composite allotransplantation

Martin Kumnig, Sheila G. Jowsey‐Gregoire, Elisa J. Gordon, Gabriele Werner‐Felmayer

Vascularized Composite Allotransplantation (VCA) has evolved in recent years, encompassing hand, face, uterus, penile, and lower extremity transplantation. Accordingly, without centralized oversight by United States Organ Procurement and Transplantation Network (OPTN) or European Programs, centers have developed their own practices and procedures …

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Attitudes of European students towards family decision-making and the harmonisation of consent systems in deceased organ donation: a cross-national survey

Alberto Molina Pérez, Gabriele Werner‐Felmayer, Kristof Van Assche, Anja Marie Bornø Jensen et autres

BACKGROUND: European countries are increasingly harmonising their organ donation and transplantation policies. Although a growing number of nations are moving to presumed consent to deceased organ donation, no attempts have been made to harmonise policies on individual consent and the role of …

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Attitudes of European students towards family decision-making and the harmonisation of consent to deceased organ donation: A comparative cross-sectional survey

Alberto Molina Pérez, Gabriele Werner‐Felmayer, Kristof Van Assche, Anja Marie Bornø Jensen et autres

Abstract Background: European countries are increasingly harmonising their organ donation and transplantation policies. Although a growing number of nations are moving to presumed consent, no attempts have been made to harmonise policies on individual consent and the role of the family in …

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Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown

S. Sailer, Katharina Lackner, Mia L. Pras‐Raves, Eric Wever et autres

Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this enzyme can be detected in a variety of tissues including adipose tissue. …

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Essential role of a conserved aspartate for the enzymatic activity of plasmanylethanolamine desaturase

Ernst R. Werner, Monica L. Fernández‐Quintero, Nicolas Hulo, Georg Golderer et autres

Plasmalogens are an abundant class of glycerophospholipids in the mammalian body, with special occurrence in the brain and in immune cell membranes. Plasmanylethanolamine desaturase (PEDS1) is the final enzyme of plasmalogen biosynthesis, which introduces the characteristic 1-O-alk-1'-enyl double bond. The recent sequence …

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When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping

S. Sailer, Stefan Coassin, Katharina Lackner, Caroline Fischer et autres

BACKGROUND: Genome editing in mice using either classical approaches like homologous recombination or CRISPR/Cas9 has been reported to harbor off target effects (insertion/deletion, frame shifts or gene segment duplications) that lead to mutations not only in close proximity to the target site …

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