Nicolas Hulo

Swiss community-based surveillance of respiratory virus co-occurrence in 2022–2024

F. Pérez-Rodríguez, Ana Rita Goncalves Cabecinhas, Patricia Suter-Boquete, Tania Spedaliero et autres

Viral respiratory infections (VRIs) are a persistent global health concern, driven by the year-round circulation of diverse viruses. During the coronavirus disease 2019 (COVID-19) pandemic, the prevalence of most respiratory viruses declined sharply following nonpharmaceutical interventions. Their subsequent resurgence and co-circulation with …

ch, ru, us, fr (code pays fourni par la source)

A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion

Syrian G. Sanchez, Romuald Haase, David J. Dubois, Margaux Héritier et autres

The Major Facilitator Superfamily (MFS) comprises a large and diverse group of membrane transport proteins involved in the translocation of metabolites across cellular membranes. The genome of Toxoplasma gondii encodes approximately 60 putative MFS transporters, yet the functions of most remain poorly …

ch (code pays fourni par la source)

A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion

Syrian G. Sanchez, Romuald Haase, David J. Dubois, Margaux Héritier et autres

The Major Facilitator Superfamily (MFS) comprises a large and diverse group of membrane transport proteins involved in the translocation of metabolites across cellular membranes. The genome of Toxoplasma gondii encodes approximately 60 putative MFS transporters, yet the functions of most remain poorly …

Phosphoenolpyruvate carboxykinase 1-mediated cataplerosis is required to maintain mitochondrial fitness and to avoid kidney disease progression

Anna Maria Rinaldi, Xiaorong Fu, Lucie Chanvillard, Aurélie Huber et autres

INTRODUCTION: Metabolic alterations are recognized as key features of kidney injury, but their causal role in kidney repair remains debatable. Here, we investigate the role of phosphoenolpyruvate carboxykinase 1 (PCK1), an enzyme involved in gluconeogenesis and cataplerosis (removal of tricarboxylic acid (TCA) …

ch, us (code pays fourni par la source)

Correction: Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

Samarpan Maiti, Kaushik Bhattacharya, Diana Wider, Dina Hany et autres

Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

Samarpan Maiti, Kaushik Bhattacharya, Diana Wider, Dina Hany et autres

Cells are exposed to a wide variety of internal and external stresses. Although many studies have focused on cellular responses to acute and severe stresses, little is known about how cellular systems adapt to sublethal chronic stresses. Using mammalian cells in culture, …

ch, Égypte (code pays fourni par la source)

Author Response: Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

Samarpan Maiti, Kaushik Bhattacharya, Diana Wider, Dina Hany et autres

Human cells adapt to chronic mild stresses, such as slightly elevated temperature, by getting larger in a process that couples increased translation to increased cell size in an Hsp90-dependent manner.

ch (code pays fourni par la source)

SARS-CoV-2 convalescence and hybrid immunity elicits mucosal immune responses

Olha Puhach, Mathilde Bellon, Kenneth Adea, Meriem Bekliz et autres

BACKGROUND: Mucosal antibodies play a key role in the protection against SARS-CoV-2 infection in the upper respiratory tract, and potentially in limiting virus replication and therefore onward transmission. While systemic immunity to SARS-CoV-2 is well understood, we have a limited understanding about …

ch, us (code pays fourni par la source)

Reviewer #1 (Public Review): Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress

Samarpan Maiti, Kaushik Bhattacharya, Diana Wider, Dina Hany et autres

Cells are exposed to a wide variety of internal and external stresses. Whereas many studies have focused on cellular responses to acute and severe stresses, little is known about how cellular systems adapt to sublethal chronic stresses. Using mammalian cells in culture, …

Reviewer #2 (Public Review): Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress

Samarpan Maiti, Kaushik Bhattacharya, Diana Wider, Dina Hany et autres

Cells are exposed to a wide variety of internal and external stresses. Whereas many studies have focused on cellular responses to acute and severe stresses, little is known about how cellular systems adapt to sublethal chronic stresses. Using mammalian cells in culture, …

ch, Égypte, fr (code pays fourni par la source)

Author Response: Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress

Samarpan Maiti, Kaushik Bhattacharya, Diana Wider, Dina Hany et autres

Cells are exposed to a wide variety of internal and external stresses. Whereas many studies have focused on cellular responses to acute and severe stresses, little is known about how cellular systems adapt to sublethal chronic stresses. Using mammalian cells in culture, …

ch (code pays fourni par la source)

Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress

Samarpan Maiti, Kaushik Bhattacharya, Diana Wider, Dina Hany et autres

Abstract Cells are exposed to a wide variety of internal and external stresses. Whereas many studies have focused on cellular responses to acute and severe stresses, little is known about how cellular systems adapt to sublethal chronic stresses. Using mammalian cells in …

ch, Égypte (code pays fourni par la source)