Sybrand Y. de Boer

Long-Term Outcomes of Early Surgery vs Endoscopy First in Chronic Pancreatitis

Charlotte L. van Veldhuisen, Marinus Abraham Kempeneers, Florence E.M. de Rijk, Stefan A.W. Bouwense et autres

Importance: Patients with painful chronic pancreatitis and a dilated pancreatic duct can be treated by early surgery or an endoscopy-first approach. Objective: To compare long-term clinical outcomes of early surgery vs an endoscopy-first approach using follow-up data from the ESCAPE randomized clinical …

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Post-colonoscopy colorectal cancers in a national fecal immunochemical test-based colorectal cancer screening program

Pieter H.A. Wisse, Sybrand Y. de Boer, Marco Oudkerk Pool, Jochim S. Terhaar sive Droste et autres

Abstract Background Post-colonoscopy colorectal cancers (PCCRCs) decrease the effect of colorectal cancer (CRC) screening programs. To enable PCCRC incidence reduction in the long-term, we classified PCCRCs diagnosed after colonoscopies performed in a fecal immunochemical test (FIT)-based screening program. Methods PCCRCs diagnosed after …

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The Effectiveness and Safety of First-Line Thioguanine in Thiopurine-Naïve Inflammatory Bowel Disease Patients

Femke Crouwel, Ahmed B. Bayoumy, Chris J. Mulder, Job Peters et autres

BACKGROUND: Currently thioguanine is solely used as treatment for inflammatory bowel disease after azathioprine and/or mercaptopurine failure. This study aimed to determine the safety, effectiveness, and 12-month drug survival of thioguanine in thiopurine-naïve patients with inflammatory bowel disease. METHODS: A retrospective cohort …

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Adenoma Detection Rate and Risk for Interval Postcolonoscopy Colorectal Cancer in Fecal Immunochemical Test–Based Screening

Pieter H.A. Wisse, Nicole Stephanie Erler, Sybrand Y. de Boer, Bert den Hartog et autres

BACKGROUND: The adenoma detection rate (ADR) is an essential quality indicator for endoscopists performing colonoscopies for colorectal cancer (CRC) screening as it is associated with postcolonoscopy CRCs (PCCRCs). Currently, data on ADRs of endoscopists performing colonoscopies in fecal immunochemical testing (FIT)-based screening, …

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P592 Effectiveness and safety of thioguanine in thiopurine-naïve Inflammatory Bowel Disease patients

Femke Crouwel, Ahmed B. Bayoumy, Chris J J Mulder, Job Peters et autres

Abstract Background Currently thioguanine is considered as off-label rescue therapy for Inflammatory Bowel Disease (IBD) after conventional thiopurine failure. This study aimed to determine the safety, effectiveness and 12-month drug tolerability of thioguanine in thiopurine-naïve IBD patients. Methods We performed an analysis …

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No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies

Christoph Engel, Hans F. A. Vasen, Toni T. Seppälä, Stefan Aretz et autres

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Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients

Melek Simsek, Berrie Meijer, Dewkoemar Ramsoekh, Gerd Bouma et autres

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Risk Factors and Clinical Outcomes of Head and Neck Cancer in Inflammatory Bowel Disease: A Nationwide Cohort Study

Loes H.C. Nissen, Lauranne A. A. P. Derikx, A Jacobs, Carla ML van Herpen et autres

Background: Immunosuppressed inflammatory bowel disease (IBD) patients are at increased risk to develop extra-intestinal malignancies. Immunosuppressed transplant patients show increased incidence of head and neck cancer with impaired survival. This study aims to identify risk factors for oral cavity (OCC) and pharyngeal …

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Hyperglycemia Reduces Gastric Secretory and Plasma Pancreatic Polypeptide Responses to Modified Sham Feeding in Humans

W. F. Lam, Ad Masclee, Sybrand Y. de Boer, Cornelis B.H.W. Lamers

We have investigated the effect of acute stable hyperglycemia on gastric acid secretion and serum gastrin and pancreatic polypeptide (PP) release. Gastric acid output was measured under basal conditions and in response to modified sham feeding (MSF) in 7 healthy volunteers on …

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NQO1 and NFE2L2 polymorphisms, fruit and vegetable intake and smoking and the risk of colorectal adenomas in an endoscopy‐based population

Mariken J. Tijhuis, Marleen H. P. W. Visker, Jac M. M. J. G. Aarts, Wijnand Laan et autres

Both environment and genetics contribute to the pathogenesis and prevention of colorectal neoplasia. NAD(P)H: quinone oxidoreductase (NQO1) is a detoxification enzyme that is polymorphic and inducible. We investigated interactions between lifestyle factors and polymorphisms in NQO1 and its key regulatory transcription factor …

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Maintenance treatment with budesonide 6 mg versus 9 mg once daily in patients with Crohn's disease in remission.

Dirk J. de Jong, D. J. Bac, Gie Tan, Sybrand Y. de Boer et autres

BACKGROUND: In previous trials, budesonide 6 mg/day was able to prolong the time to relapse in patients with quiescent Crohn's disease and budesonide 9 mg/day was effective in active disease with limited side effects. The aim of this study was to compare …

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Folic Acid and Vitamin B-12 Supplementation Does Not Favorably Influence Uracil Incorporation and Promoter Methylation in Rectal Mucosa DNA of Subjects with Previous Colorectal Adenomas ,

Maureen van den Donk, Linette Pellis, Jimmy W. Crott, Manon van Engeland et autres

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