Soo‐Yeon Hwang

BRG1-mediated suppression of ferroptosis underlies BTK inhibitor resistance

Soo‐Yeon Hwang, Xiangao Huang, Helgi Nikolli, Belem Yoval‐Sánchez et autres

Resistance to Bruton's tyrosine kinase inhibitors (BTKi) remains a major therapeutic challenge in B-cell malignancies. Here, we identify chromatin remodeler BRG1-mediated suppression of ferroptosis as a central mechanism of BTKi resistance in mantle cell lymphoma (MCL), in which aberrant BRG1-dependent transcription program …

us, kr (code pays fourni par la source)

AI-driven discovery of bronopol for the treatment of pulmonary fibrosis via inhibition of fibroblast activation

Hyunsik Kim, Soo‐Yeon Hwang, Sun-Ho Lee, Jae-Hwan Kwon et autres

kr (code pays fourni par la source)

Discovery of a Small-Molecule Inhibitor Targeting the ELF3-HSP27 Interaction to Suppress Breast Cancer Progression

Yi Liu, Sehyun Jung, Soo‐Yeon Hwang, Hyunji Jo et autres

Background: Breast cancer remains a leading cause of cancer-related mortality in women, largely due to metastasis and treatment resistance. ELF3, an ETS transcription factor, has been linked to cancer progression; however, the mechanisms regulating its activity remain incompletely understood. Methods: ELF3 expression …

kr (code pays fourni par la source)

Leveraging BRG1 Driven Ferroptosis Resistance to Overcome Treatment Resistance

Soo‐Yeon Hwang, Helgi Nikolli, Belem Yoval‐Sánchez, Peter Martin et autres

Resistance to Bruton's tyrosine kinase inhibitors (BTKi) remains a major therapeutic challenge in B-cell malignancies, limiting treatment durability. Here, we identify ferroptosis suppression as a central mechanism of BTKi resistance in mantle cell lymphoma (MCL). Aberrant BRG1 activity protects cells from BTKi-induced …

us, kr (code pays fourni par la source)

Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRASG13D colorectal cancer

Soo‐Yeon Hwang, Yoojeong Seo, Seojeong Park, Seul-Ah Kim et autres

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, with KRAS mutations playing a significant role in its tumorigenesis. Among the KRAS variants, the G13D mutation is associated with poor prognosis and distinctive biological behaviors. This study focuses on the …

kr (code pays fourni par la source)

Calpain 2 Isoform‐Specific Cleavage of Filamin A Enhances HIF1α Nuclear Translocation, Promoting Metastasis in Triple‐Negative Breast Cancer

Kyung‐Hwa Jeon, Seojeong Park, Eun Seon Pak, Jeong‐Ahn Kim et autres

ABSTRACT Triple‐negative breast cancer (TNBC) remains a challenge due to its aggressive nature and limited therapeutic options. Calpain 2, a member of the calcium‐dependent cysteine protease family, is particularly associated with poor prognosis in TNBC. This study explores the isoform‐specific role of …

kr (code pays fourni par la source)

Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila

Jin Woo Lee, Kyung-Ah Lee, In-Hwan Jang, Ki-Bum Nam et autres

While it is now accepted that the microbiome has strong impacts on animal growth promotion, the exact mechanism has remained elusive. Here we show that microbiome-emitted scents contain volatile somatotrophic factors (VSFs), which promote host growth in an olfaction-independent manner in Drosophila. …

kr, pr, am (code pays fourni par la source)

Synthesis and biological assessment of chalcone and pyrazoline derivatives as novel inhibitor for ELF3-MED23 interaction

Soo‐Yeon Hwang, Kyung‐Hwa Jeon, Hwa-Jong Lee, Inhye Moon et autres

HER2 overexpression significantly contributes to the aggressive nature and recurrent patterns observed in various solid tumors, notably gastric cancers. Trastuzumab, HER2-targeting monoclonal antibody drug, has shown considerable clinical success; however, readily emerging drug resistance emphasizes the pressing need for improved interventions in …

kr (code pays fourni par la source)

Author response: Synthesis and biological assessment of chalcone and pyrazoline derivatives as novel inhibitor for ELF3-MED23 interaction

Soo‐Yeon Hwang, Kyung‐Hwa Jeon, Hwa-Jong Lee, Inhye Moon et autres

Structure-based designed chalcone and pyrazoline derivatives inhibited the ELF3-MED23 protein-protein interaction, leading to HER2 downregulation and retardation of tumor growth in HER2-positive gastric cancer.

kr (code pays fourni par la source)

Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as Novel Inhibitor for ELF3-MED23 Interaction

Soo‐Yeon Hwang, Kyung‐Hwa Jeon, Hwa-Jong Lee, Inhye Moon et autres

Abstract HER2 overexpression significantly contributes to the aggressive nature and recurrent patterns observed in various solid tumors, notably gastric cancers. Trastuzumab, HER2-targeting monoclonal antibody drug, has shown considerable clinical success, however, readily emerging drug resistance emphasizes the pressing need for improved interventions …

kr (code pays fourni par la source)

Author response: Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as Novel Inhibitor for ELF3-MED23 Interaction

Soo‐Yeon Hwang, Kyung‐Hwa Jeon, Hwa-Jong Lee, Inhye Moon et autres

HER2 overexpression significantly contributes to the aggressive nature and recurrent patterns observed in various solid tumors, notably gastric cancers. Trastuzumab, HER2-targeting monoclonal antibody drug, has shown considerable clinical success, however, readily emerging drug resistance emphasizes the pressing need for improved interventions in …

kr (code pays fourni par la source)

Reviewer #1 (Public Review): Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as Novel Inhibitor for ELF3-MED23 Interaction

Soo‐Yeon Hwang, Kyung‐Hwa Jeon, Hwa-Jong Lee, Inhye Moon et autres

HER2 overexpression significantly contributes to the aggressive nature and recurrent patterns observed in various solid tumors, notably gastric cancers. Trastuzumab, HER2-targeting monoclonal antibody drug, has shown considerable clinical success, however, readily emerging drug resistance emphasizes the pressing need for improved interventions in …

kr (code pays fourni par la source)