Susan S. Padalecki

Evaluating Underrepresentation in Cancer Clinical Trial Enrollment Across Three National Cancer Institute–Designated Cancer Centers: A Retrospective Demographic Study

Guannan Gong, Jessica Liu, Mahanazuddin Syed, Katherine Worley et autres

PURPOSE To assess the generalizability of cancer clinical trials by comparing trial enrollment with baseline cancer populations across three National Cancer Institute (NCI)–designated cancer centers and to identify institutional barriers and best practices. METHODS We conducted a retrospective analysis (2020-2024) of three …

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Data from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Rachelle W. Johnson, Mai Phuong Nguyen, Susan S. Padalecki, Barry G. Grubbs et autres

Abstract Breast cancer frequently metastasizes to bone, in which tumor cells receive signals from the bone marrow microenvironment. One relevant factor is TGF-β, which upregulates expression of the Hedgehog (Hh) signaling molecule, Gli2, which in turn increases secretion of important osteolytic factors …

Supplementary Figure Legends 1-2 from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Rachelle W. Johnson, Mai Phuong Nguyen, Susan S. Padalecki, Barry G. Grubbs et autres

Supplementary Figure Legends 1-2 from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Supplementary Figure 1 from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Rachelle W. Johnson, Mai Phuong Nguyen, Susan S. Padalecki, Barry G. Grubbs et autres

Supplementary Figure 1 from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Supplementary Figure 1 from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Rachelle W. Johnson, Mai Phuong Nguyen, Susan S. Padalecki, Barry G. Grubbs et autres

Supplementary Figure 1 from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Supplementary Figure Legends 1-2 from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Rachelle W. Johnson, Mai Phuong Nguyen, Susan S. Padalecki, Barry G. Grubbs et autres

Supplementary Figure Legends 1-2 from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Data from TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Rachelle W. Johnson, Mai Phuong Nguyen, Susan S. Padalecki, Barry G. Grubbs et autres

Abstract Breast cancer frequently metastasizes to bone, in which tumor cells receive signals from the bone marrow microenvironment. One relevant factor is TGF-β, which upregulates expression of the Hedgehog (Hh) signaling molecule, Gli2, which in turn increases secretion of important osteolytic factors …

Developing a model to predict accrual to cancer clinical trials: Data from an NCI designated cancer center

Praveena Iruku, Martin W. Goros, Jonathan Gelfond, Jenny C. Chang et autres

INTRODUCTION: As cancer center funds are allocated toward several resources, clinical trial offices and the clinical trial infrastructure is constantly scrutinized. It has been shown that 20% of clinical trials fail to achieve their accrual goal and in an institutional level several …

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The Development of a Minority Recruitment Plan for Cancer Clinical Trials

Monica Treviño, Susan S. Padalecki, Anand B. Karnad, Alberto Parra

BACKGROUND: Cancer does not occur in all ethnic and racial groups at similar rates. In addition, responses to treatment also vary in certain ethnic and racial groups. For Hispanics, the overall cancer incidence is generally lower yet for some specific tumor types, …

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Temporal Changes in the Clinical Approach to Diagnosing Prostate Cancer

W. Mark Hilton, Susan S. Padalecki, Donna Pauler Ankerst, Robin J. Leach et autres

The diagnosis and detection of prostate cancer has undergone profound changes over the past three decades, due primarily to the development and widespread clinical use of prostate-specific antigen (PSA) testing. These changes have led to substantial differences in the prostate cancer phenotype. …

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Hyaluronic Acid as a Target for Intervention in Prostate Cancer Metastases

Susan S. Padalecki

Abstract : Bone metastases are a debilitating and devastating complication for patients with advanced prostate cancer. Unfortunately, treatment options for patients with bone metastases are limited. Both hyaluronan synthase (HAS) and hyaluronic acid (HA) are upregulated in metastatic prostate cancer cells. 7-Hydroxy-4-Methyl …

TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

Rachelle W. Johnson, Mai Phuong Nguyen, Susan S. Padalecki, Barry G. Grubbs et autres

Breast cancer frequently metastasizes to bone, in which tumor cells receive signals from the bone marrow microenvironment. One relevant factor is TGF-β, which upregulates expression of the Hedgehog (Hh) signaling molecule, Gli2, which in turn increases secretion of important osteolytic factors such …

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