Jonathan Gelfond

Radiofrequency Ablation Versus Cryoablation of the Posterior Nasal Nerve for Chronic Rhinitis: A Meta-Analysis and Systematic Review

Tim A. Mose, Prem C. Patel, Jonathan Gelfond, Megana Challa et autres

Background Posterior nasal nerve (PNN) ablation has demonstrated efficacy for chronic rhinitis, although differences between radiofrequency ablation (RFA) and cryoablation (CA) remain unclear. This meta-analysis aims to indirectly compare long-term efficacy and safety between these modalities. Methods A search for studies reporting …

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Configuring REDCap to Support Complex Systematic Review Workflows: A User-Centered Design and Implementation Case Study. (Preprint)

Muayad Hamidi, Rahma Mungia, Jonathan Gelfond, Shweta Bansal et autres

BACKGROUND Background: Systematic literature reviews require transparent and reproducible workflows for screening, data abstraction, critical appraisal, discrepancy resolution, and auditability. While most low-cost, institutionally accessible systematic review platforms can streamline citation screening and review management, systematic reviews with complex structures/themes may require …

Gut Microbiome as a Lifestyle Risk Factor Associated with Prostate Cancer

Michael A. Liss, James R. White, Molly Doris, Zhao Lai et autres

BACKGROUND AND OBJECTIVE: Most prostate cancer prevention strategies suggest lifestyle modifications, which lack personalization. Gut microbiome is increasingly recognized as an influencing factor in nongastrointestinal cancers, including prostate cancer. The use of gut microbiome as a lifestyle biomarker could help identify individuals …

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The loss of methionine sulfoxide reductases significantly suppresses tumor development and exacerbates kidney pathology in male quadruple Msr knockout mice

Lisa C. Flores, Ganga Tandukar, Colton Allen, Adam B. Salmon et autres

To investigate the effects of the loss of methionine sulfoxide reductase (Msr) on aging, we have conducted the survival and end-of-life pathological analyses using male quadruple Msr knockout (KO) mice lacking MsrA, MsrB1, MsrB2, and MsrB3. Our study demonstrated that the loss …

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Joint Biochemical and Genetic Prostate Cancer Risk Stratification

Nicole Zeltser, Roni Haas, Christine Ibilibor, Jonathan Gelfond et autres

PURPOSE: Overdiagnosis of prostate cancer (PC) through PSA testing at short intervals remains common. While baseline serum PSA abundance < 1 ng/mL warrants infrequent screening, it is critical to foster advanced diagnostic practices for men with baseline serum PSA ≥ 1 ng/mL, …

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Deciphering the timing and impact of life-extending interventions: temporal efficacy profiler distinguishes early, midlife, and senescence phase efficacies

Nisi Jiang, Catherine Cheng, Qianqian Liu, Randy Strong et autres

A growing number of compounds are reported to extend lifespan, but it remains unclear whether they reduce mortality across the entire life course or only at specific ages. This uncertainty persists because the commonly used log-rank test cannot detect age-specific effects. Here, …

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The genomic differences in hispanic vs non hispanic patients with primary central nervous system lymphoma

Supreet Kaur, Abhishek Pandya, Xiaojing Wang, Jonathan Gelfond et autres

Abstract Introduction: Primary Central Nervous system lymphomas (PCNSL) account for ~ 4% of newly diagnosed CNS tumors with an annual incidence rate of 0.5 per 100,000 in the United States. There have been varied reports from large databases including SEER stating that …

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Development and evaluation of the phenotypic 2G test to detect drug-resistant TB

Joshua Garcia, Edson Mambuque, Amberlee Hicks, Alyssa Schami et autres

SUMMARY BACKGROUND Early diagnosis of TB with drug susceptibility testing (DST) is critical to achieve successful treatment outcomes. We aimed to develop and test a novel colorimetric, 12-well, thin-layer agar-based test to assess its accuracy for TB diagnosis and DST in a …

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Correlates of asymptomatic sexually transmitted infections among marginalized women in the Dominican Republic

Michelle Chang, Delivette Castor, Craig J. Heck, Brian Hernandez et autres

BackgroundSexually transmitted infections (STIs) continue to cause morbidity among women in resource-constrained settings, where asymptomatic infections are often overlooked due to syndromic management protocols. We investigated correlates of asymptomatic STIs among women in the Dominican Republic (DR).MethodsWe analyzed data collected from cisgender …

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Performance of the low-cost phenotypic thin-layer agar MDR/XDR-TB Colour Test (first generation, 1G, Color Plate Test) for identifying drug-resistant Mycobacterium tuberculosis isolates in a resource-limited setting

Binyam Mebrat, Juan Ignacio García, Yimtubezenash Woldeamanuel, Kelemework Adane et autres

BACKGROUND: The accessible, easy to use and timely, diagnosis of tuberculosis (TB) drug-susceptibility, is often challenging, particularly in resource-constrained settings. We therefore evaluated the phenotypic thin-layer agar based MDR/XDR-TB Colour Test, also known as the "First Generation (1G) Color Plate Test (TB-CX)" …

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Saturation of respiratory strain during robotic hysterectomy in obese women with endometrial cancer

Edward R. Kost, Martin Goros, Paulina Ramirez, Jonathan Gelfond et autres

To evaluate intraoperative ventilatory mechanics during robotic-assisted hysterectomy in obese women with endometrial cancer and introduce the concept of a physiologic "ceiling effect" in respiratory strain. We conducted a retrospective cohort study of 89 women with biopsy-confirmed endometrial cancer who underwent robotic-assisted …

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Neuropsychiatric symptoms cluster as primary drivers of Long COVID complexity: a South Texas retrospective cohort study

Anne Marie Wells, Summer Rolin, Barbara Robles-Ramamurthy, Gabriela Gibson-Lopez et autres

Long COVID, previously known as Post-Acute Sequelae of SARS-CoV-2 (PASC), refers to prolonged symptoms or diagnosable conditions following COVID-19 infection. The neuropsychiatric profile of Long COVID patients remains ambiguous. This study aimed to assess neuropsychiatric symptoms in a retrospective cohort of Long …

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