Melissa Lazar

Does resection of cavity shave margins impact survival in breast cancer patients?

Anees B. Chagpar, Kristalyn K. Gallagher, Carlos Garcia-Cantu, Marissa Howard-McNatt et autres

513 Background: Randomized controlled trials have shown that resection of cavity shave margins (CSM) halves the margin positivity and re-excision rate in breast cancer (bc) patients (pts), but the impact on overall (OS) and disease-free survival (DFS) remains unclear. Methods: Between Oct …

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Abstract 2041: Short-term pre-operative caloric restriction downregulates miR-21 and modulates gut microbiome in breast cancer and prostate cancer patients.

Meera Gupta, Anuradha A. Shastri, Pramila R. Anné, Tiziana DeAngelis et autres

Abstract Purpose: Calorie restriction (CR) has been shown to improve oncological markers in numerous studies, the mechanism and extent to which it can modulate clinical outcomes remain of interest. In this study, we sought to determine the effect of a 2-5-week preoperative …

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Intimacy After Diagnosis: Navigating Sexual Health Conversations and Disparities Among Cancer Survivors

Tolulope Ilori, Katherine Gerber, Sara Burke, Ayako Shimada et autres

Objective We designed a survey to determine the prevalence of sexual dysfunction among cancer patients and to understand the gaps in provider-patient communication. Methods An IRB-approved 36-item survey was distributed through the Jefferson Recruitment Enhancement Service team and social media. Questions assessed …

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Past Trauma and Its Effects on Patient Perception during Breast Cancer Radiotherapy

Kate Gerber, Stephen Burke, Ayesha Ali, J.R. Rocchetti et autres

The Promise study: A presurgical randomized clinical trial of CE/BZA vs placebo in postmenopausal women with ductal carcinoma in situ.

Swati Kulkarni, Geoffrey L. Greene, Luis Z. Blanco, Thea D. Tlsty et autres

512 Background: Conjugated estrogen/bazedoxifene (CE/BZA), the first tissue selective estrogen complex, was developed as an alternative to combination estrogen and progesterone therapy to treat hot flashes and osteoporosis. Preclinical studies found that CE/BZA reduced mammary ductal proliferation and increased expression of anti-tumorigenic …

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Dental care for the institutionalized elderly population – A literature review

M. R. Cosoroabă, Emanuela Petrescu, C. M. Pantea, D. E. Bojoga et autres

The current article is meant to be a literature review based on our findings regarding the dental care issues in the geriatric community. The purpose was the focus to finding out information about what communities from around the world are doing in …

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Characterizing Sentinel Lymph Node Status in Breast Cancer Patients Using a Deep-Learning Model Compared With Radiologists' Analysis of Grayscale Ultrasound and Lymphosonography

Priscilla Machado, Aylin Tahmasebi, Samuel J. Fallon, Ji‐Bin Liu et autres

ABSTRACT: The objective of the study was to use a deep learning model to differentiate between benign and malignant sentinel lymph nodes (SLNs) in patients with breast cancer compared to radiologists' assessments.Seventy-nine women with breast cancer were enrolled and underwent lymphosonography and …

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Surgical management of complicated right colon cancer

Melissa Lazar

The management of complicated right colon cancer has a standard recommendation represented by right colectomy with primary anastomosis.There seems to be an important percentage of patients for whom a damage control type procedure can be performed as a first step of a …

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Abstract B048: Disparities in treatment course and outcomes in females diagnosed with non-metastatic inflammatory breast cancer

Kirsten Lung, Young Sheng, Brandon George, Alliric I. Willis et autres

Abstract Background: Inflammatory breast cancer (IBC) is an uncommon, aggressive disease with a poor prognosis. National treatment guidelines recommend neoadjuvant chemotherapy followed by modified radical mastectomy (MRM) and radiation. Disparities in treatment may contribute to survival differences, and few studies have assessed …

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Novel Form of Breast Intraoperative Radiation Therapy with CT-Guided High-Dose-Rate Brachytherapy: Interim Results of a Prospective Phase-II Clinical Trial

Lena M Turkheimer, Gina R. Petroni, Adam C. Berger, Anneke T. Schroen et autres

BACKGROUND: Precision breast intraoperative radiation therapy (PB-IORT) is a novel method of IORT that uses customized CT-based treatment plans and high-dose-rate (HDR) brachytherapy. We conducted a phase-II multi-institution trial to evaluate the efficacy of PB-IORT. STUDY DESIGN: Between 2015 and 2022, 3 …

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Does Preoperative MRI Reduce Positive Margins after Breast-Conserving Surgery?

Ashley Cairns, Anees B. Chagpar, Elisabeth Dupont, Edward A. Levine et autres

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Sentinel Lymph Node Identification in Post Neoadjuvant Chemotherapy Breast Cancer Patients Undergoing Surgical Excision Using Lymphosonography

Priscilla Machado, Ji‐Bin Liu, Laurence Needleman, Melissa Lazar et autres

OBJECTIVES: This study evaluated the efficacy of lymphosonography in the identification of sentinel lymph nodes (SLNs) in post neoadjuvant chemotherapy patients with breast cancer scheduled to undergo surgical excision. METHODS: Seventy-nine subjects scheduled for breast cancer surgery with SLN excision completed this …

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