Accès ouvert
2026
article
OpenAlex
Diệp Minh Triết Đoàn, Quản Minh Hòa, Chuong Nguyen
The use of generative AI (GenAI) in learning creates a need for assessment instruments that are appropriate to learners’ developmental characteristics, learning purposes, and educational contexts. Existing scales, however, have largely been developed for higher education or non-Vietnamese contexts, whereas high school …
vn, tw
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Accès ouvert
2026
preprint
OpenAlex
Hannah B. L. Jones, Simeon D. Draganov, Sofia Schönbauer Huamán, Peter A. C. Wing et autres
gb, us
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Accès ouvert
2025
preprint
OpenAlex
Hannah B. L. Jones, Simeon D. Draganov, Sofia Schönbauer Huamán, Peter A. C. Wing et autres
Abstract Deubiquitinases (DUBs), and the dysregulation thereof, are implicated in human disease. The recent inclusion of selective DUB inhibitors in clinical trials has heightened interest in DUB-focused drug discovery. Current DUB screening methods remain constrained, however, as they often rely on recombinant …
gb, kh, us
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Accès ouvert
2025
article
OpenAlex
Divya Veerapaneni, Naveen Arunachalam Sakthiyendran, Yili Du, Leigh Ann Mallinger et autres
IMPORTANCE: In patients with traumatic brain injury (TBI), baseline pupillary assessment is routine; however, the occurrence rate and clinical significance of pupil abnormalities over the early course of hospitalization remain poorly characterized. OBJECTIVES: To determine whether the occurrence and frequency of pupil …
us, ca
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Accès ouvert
2025
article
OpenAlex
Brooke A. Conti, Leo Novikov, Deyan Tong, Qing Xiang et autres
DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a chemotherapeutic …
us
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Accès ouvert
2025
peer-review
OpenAlex
Brooke A. Conti, Leo Novikov, Deyan Tong, Qing Xiang et autres
All mammals store their genetic material in the form of DNA, which is constantly damaged by factors such as ultraviolet radiation, chemicals, and errors during cellular processes. To prevent such damage from causing harmful mutations, it is important that cells have repair …
us
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Accès ouvert
2025
peer-review
OpenAlex
Brooke A. Conti, Leo Novikov, Deyan Tong, Qing Xiang et autres
DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a chemotherapeutic …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Brooke A. Conti, Leo Novikov, Deyan Tong, Qing Xiang et autres
Abstract DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Divya Veerapaneni, Naveen Arunachalam Sakthiyendran, So Yeon Kim, Chuong Nguyen et autres
Abstract Importance In patients with traumatic brain injury (TBI), baseline pupillary assessment is common. However, the incidence and frequency of pupil abnormalities within the first several days remain poorly characterized. Objectives Our aim was to test the association between pupil abnormality frequency …
us
(code pays fourni par la source)
Accès ouvert
2024
peer-review
OpenAlex
Brooke A. Conti, Leo Novikov, Deyan Tong, Qing Xiang et autres
DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a chemotherapeutic …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Brooke A. Conti, Leo Novikov, Deyan Tong, Qing Xiang et autres
DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a chemotherapeutic …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Brooke A. Conti, Leo Novikov, Deyan Tong, Qing Xiang et autres
Summary DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a …
us
(code pays fourni par la source)