Sofia Schönbauer Huamán

Activity-Based Proteomics Discovery of Deubiquitinating Enzyme Inhibitors with Immunomodulatory Activity

Hannah B. L. Jones, Simeon D. Draganov, Sofia Schönbauer Huamán, Peter A. C. Wing et autres

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ob ABPP-HT*: A Precision-Engineered Activity Proteomics Pipeline for the Streamlined Discovery of Deubiquitinase Inhibitors

Hannah B. L. Jones, Simeon D. Draganov, Sofia Schönbauer Huamán, Peter A. C. Wing et autres

Abstract Deubiquitinases (DUBs), and the dysregulation thereof, are implicated in human disease. The recent inclusion of selective DUB inhibitors in clinical trials has heightened interest in DUB-focused drug discovery. Current DUB screening methods remain constrained, however, as they often rely on recombinant …

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Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies

Dóra Laczi, Sofia Schönbauer Huamán, Taylah Andrews-Clark, Stephen M. Laidlaw et autres

and, by implication, other nucleophilic cysteine enzymes.

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