Matthew A. Quinn

Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer’s disease models

Anusha Pallapati, Funda Korkmaz, Satish V. Rojekar, Steven Sims et autres

There is growing evidence for direct actions of follicle-stimulating hormone (FSH) on tissues other than the ovaries and testes. Blocking FSH action, either genetically or pharmacologically, protects against bone loss, fat gain, and memory loss in mice. We thus developed a humanized …

us, nz, sk, fr, jp, gb (code pays fourni par la source)

eLife assessment: Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

Matthew A. Quinn

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries.There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the pathology of NAFLD.We previously demonstrated that gut microbiota-derived tryptophan metabolite …

us (code pays fourni par la source)

Author Response: Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Ortero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate.Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other organ …

us (code pays fourni par la source)

Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

us (code pays fourni par la source)

Reviewer #1 (Public Review): Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

us (code pays fourni par la source)

Reviewer #2 (Public Review): Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

us (code pays fourni par la source)

Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

Abstract One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in …

us (code pays fourni par la source)

Author Response: Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

us (code pays fourni par la source)

Editor's evaluation: Ferredoxin 1 is essential for embryonic development and lipid homeostasis

Matthew A. Quinn

The iron-sulfur cluster containing Ferredoxin 1 (FDX1), critical in steroidogenesis and TCA cycle, is required for mammalian embryonic development and maintenance of lipid homeostasis at cellular and organismal levels.

us (code pays fourni par la source)

eLife Assessment: Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

Matthew A. Quinn

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the pathology of NAFLD. We previously demonstrated that gut microbiota …

us (code pays fourni par la source)

eLife assessment: BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

Matthew A. Quinn

us (code pays fourni par la source)