Robert C. Jones

Heterophilic interactions between cell-surface proteins Teneurin-m and Capricious drive dendrite segregation in the Drosophila olfactory circuit

Hui Ji, Jingxian Li, Yizhen Xu, Kenneth Kin Lam Wong et autres

Summary How dendrites of different neurons segregate into discrete spatial domains during neural circuit assembly is poorly understood. Here, using the Drosophila olfactory system, we found that heterophilic interactions between two cell-surface proteins Teneurin-m (Ten-m) and Capricious (Caps) drive dendrite segregation. Ten-m …

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Tabula Sapiens reveals the non-coding RNA landscape across 22 human organs and tissues

Jaeyoon Lee, Madhav Mantri, Kavita Murthy, Luise A. Seeker et autres

The biological significance of non-coding RNAs has been increasingly appreciated as their roles in various cellular processes are uncovered. However, single-cell transcriptomic profiling of human samples has focused primarily on protein-coding genes by targeting polyadenylated RNA transcripts, leaving the expression patterns of …

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Benchmarking cell type and gene set annotation by large language models with AnnDictionary

George Crowley, Robert C. Jones, Mark A. Krasnow, Angela Oliveira Pisco et autres

We develop an open-source package called AnnDictionary to facilitate the parallel, independent analysis of multiple anndata. AnnDictionary is built on top of LangChain and AnnData and supports all common large language model (LLM) providers. AnnDictionary only requires 1 line of code to …

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Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes

Theodore dos Santos, Xiao-Qing Dai, Robert C. Jones, Aliya F Spigelman et autres

Type 1 diabetes (T1D) is characterized by the autoimmune destruction of most insulin-producing β cells, along with dysregulated glucagon secretion from pancreatic α cells. We conducted an integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of islet cells …

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A molecular cell atlas of mouse lemur, an emerging model primate

Iwijn De Vlaminck, Liza J. Shapiro, Andriamahery Razafindrakoto, Hajanirina Noëline Ravelonjanahary et autres

Abstract Mouse lemurs are the smallest and fastest reproducing primates, as well as one of the most abundant, and they are emerging as a model organism for primate biology, behaviour, health and conservation. Although much has been learnt about their ecology and …

dk, us, Madagascar, de, fr, hk, jp, cn (code pays fourni par la source)

Mouse lemur cell atlas informs primate genes, physiology and disease

Camille Ezran, Shixuan Liu, Stephen Chang, Jingsi Ming et autres

, we performed large-scale single-cell RNA sequencing of 27 organs from mouse lemurs. We identified more than 750 molecular cell types, characterized their transcriptomic profiles and provided insight into primate evolution of cell types. Here we use the generated atlas to characterize …

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Linking molecular pathways and islet cell dysfunction in human type 1 diabetes

Theodore dos Santos, Xiao Qing Dai, Robert C. Jones, Aliya F Spigelman et autres

Summary Type 1 diabetes (T1D) is characterized by the autoimmune destruction of most insulin-producing β-cells, along with dysregulated glucagon secretion from pancreatic α-cells. We conducted an integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of islet cells from …

ca, us, gb, se (code pays fourni par la source)

Framework assessment of sustainability: Methodology for evaluating the conformance of fishery and aquaculture management systems to FAO guidelines

Michelle L. Walsh, Thoren L. Thorbjørnsen, Robert C. Jones

Sustainability is about meeting the needs of current generations without compromising those of future generations. For fished and aquacultured products, sustainability is often gauged on an individual fishery or farm basis but can be driven by a well-designed and implemented regulatory management …

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An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome

Shixuan Liu, Camille Ezran, Michael F. Z. Wang, Zhengda Li et autres

Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, hormone signaling by its very nature connects cells of different organs and involves crosstalk …

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Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity

Fabio Zanini, Xibing Che, Nina E. Suresh, Carsten Knutsen et autres

Rapid expansion of the pulmonary microvasculature through angiogenesis drives alveolarization, the final stage of lung development that occurs postnatally and dramatically increases lung gas-exchange surface area. Disruption of pulmonary angiogenesis induces long-term structural and physiologic lung abnormalities, including bronchopulmonary dysplasia, a disease …

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Fetal circular shunt in Ebstein’s anomaly and non-steroidal anti-inflammatory treatment

Faith Peña, Tiffany Emanuelson, Steven Todman, Robert C. Jones et autres

A circular shunt is a poor prognostic factor associated with Ebstein's anomaly. Targeting the constriction of the ductus arteriosus (DA) in order to limit or resolve the circular shunt, has been shown to improve fetal outcomes. Prenatal non-steroidal anti-inflammatory drugs (NSAIDs) have …

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Veganism and Capitalism

Robert C. Jones, John Sanbonmatsu

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