Accès ouvert
2026
article
OpenAlex
Ning Li, Yinghui Zhang, Li Liu, Yanzi Jin et autres
Objective: To compare the short-term efficacy and safety of efgartigimod versus intravenous immunoglobulin (IVIg) in patients with impending myasthenic crisis (IMC). Methods: This single-center, randomized, open-label, prospective comparative cohort study included 38 acetylcholine receptor antibody-positive (AChR-Ab+) patients with IMC, which was defined …
cn
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Accès ouvert
2026
article
OpenAlex
Juan Yang, Wenming Wu, Jiahui Peng, Xiaoyu Liu et autres
fruit-derived extracts as natural-product-based candidates for lung cancer intervention.
cn
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Accès ouvert
2025
erratum
OpenAlex
Qintao Wang, Honghao Zhu, Xiangwei Sun, Changming Zhang et autres
In the version of this article initially published, due to figure preparation mistakes, the image shown in Fig. 2g for IL-23 was a duplicate of the GM-CSF image below; in Extended Data Fig. 2c, the C1 plot for IFN-α was a duplicate …
cn
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Accès ouvert
2025
article
OpenAlex
Qintao Wang, Honghao Zhu, Xiangwei Sun, Changming Zhang et autres
. Here we report on five patients with SLE carrying recessive mutations in phospholipase D family member 4 (PLD4). Deleterious variants in PLD4 resulted in impaired single-stranded nucleic acid exonuclease activity in in vitro and ex vivo assays. PLD4 loss-of-function mutations led …
cn
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Accès ouvert
2025
article
OpenAlex
Yuanxi Mo, An Hye Jin, Wanzi Hong, Jiahui Peng et autres
Background Isowighteone, an isoflavonoid compound derived from Ficus hispida L.f. (F. hispida, Moraceae), has demonstrated significant anti-inflammatory properties in prior studies. However, its anti-inflammatory role in vascular calcification is unclear. Object We investigated the efficacy of isowighteone in the treatment of vascular …
cn, hk
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Accès ouvert
2024
article
OpenAlex
Juan Yang, Lu Liu, Jiahui Peng, Boya Ma et autres
Rheumatoid meningitis (RM) is a rare extra-articular manifestation of rheumatoid arthritis (RA) that has been increasingly recognized by neurologists. However, the diversity of its clinical manifestations makes its diagnosis difficult. RM does not have a unified diagnostic standard, and its link with …
cn
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Accès ouvert
2024
article
OpenAlex
Yonghe Lu, Hongyu Chen, Y. M. Zhang, Jiahui Peng et autres
Currently, the primary challenges in entity relation extraction are the existence of overlapping relations and cascading errors. In addressing these issues, both CasRel and TPLinker have demonstrated their competitiveness. This study aims to explore the application of these two models in the …
cn
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Accès ouvert
2023
article
OpenAlex
Changming Zhang, Xu Han, Ying Jin, Xiang Chen et autres
BACKGROUND: Lupus nephritis is a rare immunological disorder. Genetic factors are considered important in its causation. We aim to systematically investigate the rare pathogenic gene variants in patients with lupus nephritis. METHODS: Whole-exome sequencing was used to screen pathogenic gene variants in …
cn
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Accès ouvert
2023
article
OpenAlex
Changming Zhang, Jiahui Peng, Zhihong Liu, Qing Zhou
Background: Autoinflammatory diseases (AIDs) were first proposed 20 years ago and caused by dysregulation of the innate immune system, leading to episodes of systemic inflammation. Advances in next-generation sequencing and biological technology have resulted in the identification of new monogenic diseases and …
cn
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Accès ouvert
2022
article
OpenAlex
Jiahui Peng, Yusha Wang, Xu Han, Changming Zhang et autres
Significance Statement Lupus nephritis (LN) is the major cause of death among systemic lupus erythematosus patients, with heterogeneous phenotypes and different responses to therapy. Identifying genetic causes and finding potential therapeutic targets of LN is a major unmet clinical need. We identified …
cn
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Accès ouvert
2022
article
OpenAlex
Changming Zhang, Xu Han, Li Sun, Sirui Yang et autres
ABSTRACT Background Heterozygous loss-of-function mutations in the tumour necrosis factor alpha induced protein 3 (TNFAIP3) gene cause an early-onset auto-inflammatory disease named haploinsufficiency of A20 (HA20). Here we describe three unrelated patients with autoimmune lupus nephritis (LN) phenotypes carrying three novel mutations …
cn
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