Hsuan-Wen Lin

Lead Impairs Long-Term Memory by Disrupting Mitochondrial Redox Homeostasis in Drosophila

Cheng-tzu Hsu, Te-Wei Lu, Ya-Ting Yang, Chun‐Chao Chen et autres

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Lead Impairs Long-Term Memory by Disrupting Mitochondrial Redox Homeostasis in Drosophila

Cheng-tzu Hsu, Te-Wei Lu, Ya-Ting Yang, Chun‐Chao Chen et autres

Raw Data

tw, cn (code pays fourni par la source)

Redox regulation of memory formation by Rrp1 in Drosophila

Chia‐Hsiang Hsu, Chun‐Chao Chen, Yu-Ling Hung, Yating Yang et autres

Long-term memory (LTM) formation requires precise gene regulation, yet the role of redox activity in this process remains poorly understood. Here, we identify Drosophila recombination repair protein 1 (Rrp1), a homolog of human apurinic/apyrimidinic endonuclease 1 (APE1), as a key redox regulator …

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A subset of cholinergic mushroom body neurons blocks long-term memory formation in Drosophila

Chun‐Chao Chen, Hsuan-Wen Lin, Kuan-Lin Feng, Der-Wan Tseng et autres

Long-term memory (LTM) requires learning-induced synthesis of new proteins allocated to specific neurons and synapses in a neural circuit. Not all learned information, however, becomes permanent memory. How the brain gates relevant information into LTM remains unclear. In Drosophila adults, weak learning …

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CREBB repression of protein synthesis in mushroom body gates long-term memory formation in Drosophila

Hsuan-Wen Lin, Chun‐Chao Chen, Ruei-Yu Jhang, Linyi Chen et autres

Learned experiences are not necessarily consolidated into long-term memory (LTM) unless they are periodic and meaningful. LTM depends on de novo protein synthesis mediated by cyclic AMP response element-binding protein (CREB) activity. In Drosophila , two creb genes ( crebA , crebB …

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Early Protein Synthesis after Weak Learning Inhibits Drosophila Long-Term Memory Formation

Chun‐Chao Chen, Ann‐Shyn Chiang, Hsuan-Wen Lin, Kuan-Lin Feng et autres

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Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation in Drosophila

Kuan-Lin Feng, Ju‐Yun Weng, Chun‐Chao Chen, Mohammed Bin Abubaker et autres

involves convergent projection neuron (PN; odor) and dopaminergic neuron (DAN; reinforcement) input to the mushroom body (MB). How post-training DAN activity in the posterior lateral protocerebrum (PPL1) continues to regulate memory consolidation remains unknown. Here we address this question using targeted transgenes …

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CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila

Hsuan-Wen Lin, Chun‐Chao Chen, J. Steven de Belle, Tim Tully et autres

Significance Most animals record only labile memories of single events, whereas the formation of persistent long-term memories (LTMs) usually requires recurrent experiences. Our study distinguishes these different memory types through a deconvolution of molecular/biochemical processes within specific neurons of an identified memory …

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CREB repressor in mushroom body enhances Drosophila LTM formation

Chun‐Chao Chen, Hsuan-Wen Lin, Kuan-Lin Feng, Ruei-Yu Jhang et autres

Abstract Long-term memory (LTM) requires learning-induced synthesis of new proteins allocated to specific neurons and synapses in a neural circuit. Not all learned information, however, becomes permanent memory. How the brain gates relevant information into LTM remains unclear. In Drosophila adults, a …

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CREB in Mushroom Body Gates Drosophila Long-Term Memory

Chun‐Chao Chen, Hsuan-Wen Lin, Kuan-Lin Feng, Ruei-Yu Jhang et autres

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Automatedin situbrain imaging for mapping theDrosophilaconnectome

Chi–Wen Lin, Hsuan-Wen Lin, Mei-Tzu Chiu, Yung-Hsin Shih et autres

Mapping the connectome, a wiring diagram of the entire brain, requires large-scale imaging of numerous single neurons with diverse morphology. It is a formidable challenge to reassemble these neurons into a virtual brain and correlate their structural networks with neuronal activities, which …

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Molecular Genetic Analysis of Sexual Rejection: Roles of Octopamine and Its Receptor OAMB inDrosophilaCourtship Conditioning

Chuan Zhou, Hai Huang, Susy M. Kim, Hsuan-Wen Lin et autres

After Drosophila males are rejected by mated females, their subsequent courtship is inhibited even when encountering virgin females. Molecular mechanisms underlying courtship conditioning in the CNS are unclear. In this study, we find that tyramine β hydroxylase (TβH) mutant males unable to …

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