Alessandra Viale

Euro-BioImaging – Interdisciplinary research infrastructure bringing together communities and imaging facilities to support excellent research

Claudia Pfander, Johanna Bischof, Marianna Childress-Poli, Antje Keppler et autres

We wanted to create a highly-qualified network of expertise, know-how, and cutting-edge technologies, and innovation platforms, by bringing together the most qualified imaging centers in Europe.We run the gamut from noninvasive imaging to invasive validation and from invasive discovery to noninvasive translation. …

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Insights into Interfacial Water Structuring at the Nafion Surface by T1-Weighted Magnetic Resonance Imaging

Giulia Spatola, Alessandra Viale, Elisa Brussolo, Rita Binetti et autres

-weighted magnetic resonance images of water in the surroundings of a Nafion surface allowed the identification of the presence of a low-mobility zone (LMZ), 60 μm thick, consisting of water molecules structured in a hydrogen-bonding network, promoted by the presence of the …

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1H-NMR and MALDI-TOF MS as metabolomic quality control tests to classify platelet derived medium additives for GMP compliant cell expansion procedures

Francesco Agostini, Marta Ruzza, Davide Corpillo, Luca Biondi et autres

INTRODUCTION: Ex vivo cell expansion under Good Manufacturing Practice (GMP) guidelines can be performed using medium additives containing human growth factors from platelets. These products can differently affect proliferation of adipose mesenchymal stromal stem cells (ASC). Qualification of medium additive performance is …

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Relaxometry and Contrast Agents

Silvio Aime, Eliana Gianolio, Alessandra Viale

The perturbation on the relaxation of solvent water protons induced by the presence of paramagnetic metal-containing systems has been exploited for the design of contrast agents in magnetic resonance imaging applications. Complexes of Gd3+ ions were identified early as the candidates of …

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EP-1815: Technical aspects and setup irradiation of rats using a clinical accelerator

Vincenzo Sacco, Alessandra Viale, B. Noris Chiorda, Carla Sini et autres

MRI

Aileen Schroeter, Markus Rudin, Eliana Gianolio, Alessandra Viale et autres

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The Role of the Amino Protecting Group during Parahydrogenation of Protected Dehydroamino Acids

Erika Cerutti, Alessandra Viale, Carlo Nervi, Roberto Gobetto et autres

A series of dehydroamino acids endowed with different protective groups at the amino and carboxylate moieties and with different substituents at the double bond have been reacted with parahydrogen. The observed ParaHydrogen Induced Polarization (PHIP) effects in the (1)H NMR spectra are …

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15N‐Permethylated amino acids as efficient probes for MRI‐DNP applications

Enrico Chiavazza, Alessandra Viale, Magnus G. Karlsson, Silvio Aime

The synthesis, NMR properties and preliminary polarization tests on protonated and perdeuterated forms of α-trimethylglutamine (NMe3Gln), α-trimethylglutamate (NMe3Glu) and ε-trimethyllysine (NMe3Lys) are reported. The (15)N-permethylated, perdeuterated amino acids display very long (15)N-T1 values, ranging between 190 and 330 s, are well polarized …

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Para‐hydrogen induced polarization of Si‐29 NMR resonances as a potentially useful tool for analytical applications

Silvano Ellena, Alessandra Viale, Roberto Gobetto, Silvio Aime

Para-hydrogen-induced polarization effects have been observed in the (29)Si NMR spectra of trimethylsilyl para-hydrogenated molecules. The high signal enhancements and the long T(1) values observed for the (29)Si hyperpolarized resonances point toward the possibility of using (29)Si for hyperpolarization applications. A method …

15N Magnetic Resonance Hyperpolarization via the Reaction of Parahydrogen with 15N-Propargylcholine

Francesca Reineri, Alessandra Viale, Silvano Ellena, Diego Alberti et autres

(15)N-Propargylcholine has been synthesized and hydrogenated with para-H(2). Through the application of a field cycling procedure, parahydrogen spin order is transferred to the (15)N resonance. Among the different isomers formed upon hydrogenation of (15)N-propargylcholine, only the nontransposed derivative contributes to the observed …

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Hyperpolarized13C-pyruvate magnetic resonance imaging in cancer diagnostics

Alessandra Viale, Francesca Reineri, Walter Dastrù, Silvio Aime

INTRODUCTION: The use of hyperpolarized molecules allows one to obtain information about metabolism in both cells and animals; such a task represents a tremendous advancement with respect to the results achieved so far with in vivo NMR techniques. Pyruvate appears an excellent …

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Synthesis and testing of a p‐H2 hyperpolarized 13C probe based on the pyrazolo[1,5‐a]pyrimidineacetamide DPA‐713, an MRI vector to target the peripheral benzodiazepine receptors

Erika Cerutti, Alessandra Viale, Annelaure Damont, Frédéric Dollé et autres

DPA-713 is the lead compound of a recently developed 2-phenylpyrazolo[1,5-a]pyrimidineacetamide series that has been shown to display a good targeting capability toward peripheral benzodiazepine receptors, recently renamed translocator protein (18 kDa) or in short TSPO. On the basis of this structure, a …

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