Sarah E. Ehrlicher

Protein and Resistance Exercise to Stop Sarcopenic Obesity Now (PRESS ON) Pilot & Feasibility Trial

Katie M. Ellison, Sarah E. Ehrlicher, Chelsi Reynolds, Rebecca G. Rogers et autres

Objectives: Weight loss improves cardiometabolic health, but skeletal muscle loss may cause sarcopenia in at-risk adults. This pilot Sequential Multiple Assignment Randomized Trial (SMART) aimed to assess the feasibility of a future full-scale SMART to test dynamic intensive behavioral therapy (IBT) regimens …

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Body Size Measurements Grouped Independently of Common Clinical Measures of Metabolic Health: An Exploratory Factor Analysis

Katie M. Ellison, Aseel El Zein, Chelsi Reynolds, Sarah E. Ehrlicher et autres

BACKGROUND: Obesity is commonly aggregated with indices of metabolic health. Proponents of body positivity approaches question whether body size is a determinant of health and well-being. Our objective was to conduct an exploratory factor analysis (EFA) to determine if body size measurements …

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Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes

Colleen F. McKenna, Harrison D. Stierwalt, Karin A. Zemski Berry, Sarah E. Ehrlicher et autres

Postprandial hyperinsulinemia is a risk factor for type 2 diabetes and may increase muscle lipids. However, it is unclear how the relationship between acute hyperinsulinemia and the muscle lipidome interacts across metabolic phenotypes, thus contributing to insulin resistance. We observed that acute …

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Fat and fat‐free mass measurement agreement by dual‐energy X‐ray absorptiometry versus bioelectrical impedance analysis: Effects of posture and waist circumference

Katie M. Ellison, Sarah E. Ehrlicher, Aseel El Zein, R. Drew Sayer

Background: Bioelectrical impedance analysis (BIA) operates under the assumption that the conductor has a uniform cylindrical shape. However, this assumption may be violated if measures are taken in the seated position, especially in people with a high waist circumference (WC). Aims: The …

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High-fat Diet Increases ETF Synthesis And Lipid Respiration In Muscle During Training In Female Mice

Philip M. Batterson, Erin McGowan, Harrison D. Stierwalt, Sarah E. Ehrlicher et autres

Aerobic training reverses the detrimental accumulation of muscle lipids during high-fat diet (HFD)-induced obesity through unclear mechanisms. The electron-transferring flavoproteins (ETF) transfer reducing equivalents from beta-oxidation into the electron transfer system. A potential mechanism for benefits on lipid metabolism is that exercise …

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Two weeks of high-intensity interval training increases skeletal muscle mitochondrial respiration via complex-specific remodeling in sedentary humans

Philip M. Batterson, Erin McGowan, Harrison D. Stierwalt, Sarah E. Ehrlicher et autres

Aerobic training stimulates mitochondrial metabolism in skeletal muscle that is linked to improvements to whole body fuel metabolism. The mechanisms driving changes to the quantity and quality (function per unit) of mitochondria are less known. We used seven sessions of high-intensity interval …

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Impact of 4 weeks of western diet and aerobic exercise training on whole‐body phenotype and skeletal muscle mitochondrial respiration in male and female mice

Erin McGowan, Sarah E. Ehrlicher, Harrison D. Stierwalt, Matthew M. Robinson et autres

High dietary fat intake induces significant whole-body and skeletal muscle adaptations in mice, including increased capacity for fat oxidation and mitochondrial biogenesis. The impact of a diet that is high in fat and simple sugars (i.e., western diet [WD]), particularly on regulation …

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The Data Behind Popular Diets for Weight Loss

Sarah E. Ehrlicher, Tsz-Kiu Chui, Julianne G. Clina, Katie M. Ellison et autres

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Short-Term High-Fat Feeding Does Not Alter Mitochondrial Lipid Respiratory Capacity but Triggers Mitophagy Response in Skeletal Muscle of Mice

Sarah E. Ehrlicher, Harrison D. Stierwalt, Sean A. Newsom, Matthew M. Robinson

Lipid overload of the mitochondria is linked to the development of insulin resistance in skeletal muscle which may be a contributing factor to the progression of type 2 diabetes during obesity. The targeted degradation of mitochondria through autophagy, termed mitophagy, contributes to …

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Substrate-Specific Respiration of Isolated Skeletal Muscle Mitochondria after 1 h of Moderate Cycling in Sedentary Adults

Sean A. Newsom, Harrison D. Stierwalt, Sarah E. Ehrlicher, Matthew M. Robinson

INTRODUCTION: Skeletal muscle mitochondria have dynamic shifts in oxidative metabolism to meet energy demands of aerobic exercise. Specific complexes oxidize lipid and nonlipid substrates. It is unclear if aerobic exercise stimulates intrinsic oxidative metabolism of mitochondria or varies between substrates. METHODS: We …

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Skeletal Muscle ACSL Isoforms Relate to Measures of Fat Metabolism in Humans

Harrison D. Stierwalt, Sarah E. Ehrlicher, Matthew M. Robinson, Sean A. Newsom

INTRODUCTION: Evidence from model systems implicates long-chain acyl-coenzyme A synthetase (ACSL) as key regulators of skeletal muscle fat oxidation and fat storage; however, such roles remain underexplored in humans. PURPOSE: We sought to determine the protein expression of ACSL isoforms in skeletal …

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Western Diet And Exercise Training Increase Mitochondrial Lipid Respiration In Male But Not Female Mice

Erin McGowan, Sarah E. Ehrlicher, Harrison D. Stierwalt, Sean A. Newsom et autres

High-fat feeding in mice is a common model to investigate mitochondrial lipid metabolism during diet-induced obesity. Our previous work demonstrates 60% high-fat diet stimulates mitochondrial lipid respiration yet such fat content is higher than a typical western diet (~35% fat with higher …

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