Olivia H. Reid

Treatment of Cutaneous Neurofibromas in Neurofibromatosis Type 1 With MEK Inhibitor Selumetinib

Andrea M. Gross, Olivia H. Reid, Lauren Ashley Baldwin, Ashley D. Cannon et autres

Importance: Cutaneous neurofibromas (cNFs) can cause itching, disfigurement, pain, and emotional difficulties in people with neurofibromatosis type 1 (NF1). Objective: To determine the impact of the mitogen-activated protein kinase kinase inhibitor selumetinib on cNF including change in tumor volume and patient-reported outcome …

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Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial

Andrea M. Gross, Geraldine O’Sullivan Coyne, Eva Dombi, Cecilia Tibery et autres

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Data from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones et autres

AbstractPurpose: Early detection of neurofibromatosis type 1 (NF1)–associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, enabling early definitive treatment and potentially averting deadly outcomes. In this study, we describe a cell-free DNA (cfDNA) fragmentomic approach that distinguishes nonmalignant, premalignant, and malignant …

Supplementary Figure S3 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones et autres

Supplemental Figure 3. Number of NMF components versus AUC. Performance (AUC) of NMF models in OVO comparisons is plotted against the number n components (Methods) used. The number of components approaches the AUC’s asymptote in each OVO at or before 20 components. …

Supplementary Figure S4 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones et autres

Supplemental Figure 4. 4-mer end motifs across F-profiles. Comprehensive view of the distribution and prevalence of each possible 4-mer end motif within each of the six distinct F-profiles derived from non-negative matrix factorization (NMF) (Methods). The analysis highlights distinct end motif compositions …

Supplementary Figure S2 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones et autres

Supplemental Figure 2. Diminishing improvements in accuracy with deeper sequencing. MPNST samples sequenced to ∼25x were downsampled in five iterations per goal coverage (Methods). Size selected, copy number derived tumor fraction variability was noted between iterations less than or equal to 3x …

Supplementary Figure S1 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones et autres

Supplemental Figure 1. Attributes of atypical neurofibroma samples. Histologic characteristics and, when available, TSO500 clinical sequencing results for paired tissue corresponding with AN cell-free DNA.

Supplementary Tables S1-S3 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones et autres

Supplemental Table 1. Participant characteristics. Supplemental Table 2. MPNST patient characteristics. Supplemental Table 3. Details of all sequencing libraries in this study.

Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones et autres

PURPOSE: Early detection of neurofibromatosis type 1 (NF1)-associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, enabling early definitive treatment and potentially averting deadly outcomes. In this study, we describe a cell-free DNA (cfDNA) fragmentomic approach that distinguishes nonmalignant, premalignant, and malignant …

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Early detection of malignant and pre-malignant peripheral nerve tumors using cell-free DNA fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones et autres

Early detection of neurofibromatosis type 1 (NF1) associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, potentially averting deadly outcomes. Here, we describe a cell-free DNA (cfDNA) fragmentomic approach which distinguishes non-malignant, pre-malignant and malignant forms of NF1 PNST. Using plasma samples …

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A fair division solution to the problem of redistricting

Zeph A. Landau, Olivia H. Reid, I. Yu. Yershov

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Effect of vasectomy on the seminiferous tubule boundary zone in the Albino Swiss rat

Craig Charles Dobson, Olivia H. Reid, Neil K. Bennett, Stuart W. McDonald

The boundary zone of a seminiferous tubule consists of the basement membrane of the seminiferous epithelium, its myoid cells, and their basal laminae. This study examines the boundary zones of seminiferous tubules in healthy and degenerated testes following long-term, left-sided vasectomy in …

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