Hiroshi Matsuoka

Novel Integration of Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy in Pediatric Patients With Severe Burns: A Case Report

Hiroshi Matsuoka, Tomohiro Abe, Tetsu Yonaha, Takeshi Yano et autres

Acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI) represent critical complications that significantly burden the management of pediatric patients with extensive burns. We present a case of a four-year-old boy who sustained severe burns covering 56% of his total body …

jp, us (code pays fourni par la source)

Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lymphoma cells

Shiori Takeuchi, Yasuhiko Ito, Shuji Matsuoka, MASAAKI ABE et autres

Natural killer (NK)/T-cell lymphomas are a highly aggressive lymphoma subtype common in East Asia and Latin America. To develop a therapeutic monoclonal antibody (mAb) against it, BALB/c mice were alternately immunized with two vigorous NK lymphoma cell lines. After hybridization, culture supernatants …

jp (code pays fourni par la source)

Genomic and clinical parallels between US and Japanese gastric cancers: a propensity score-matched cohort study

Masaya Nakauchi, Colin M. Court, Henry S. Walch, Miseker Abate et autres

INTRODUCTION: Gastric cancer incidence, risk factors, and survival outcomes differ significantly between Japan and the United States. These disparities have led to the belief that gastric cancer represents biologically distinct diseases across regions. However, direct genomic comparisons of tumours from these populations …

us, jp, ca (code pays fourni par la source)

Sepiapterin Enhances Brain Tetrahydrobiopterin BH4-Dependent Serotonin Synthesis with Regional Specificity

Akiko Ohashi, Hiroshi Matsuoka, Shin Aizawa, Hiroyuki Hasegawa

jp (code pays fourni par la source)

An observational study of the effectiveness and safety of nivolumab plus chemotherapy for untreated advanced or recurrent gastric cancer in Japanese real-world settings: the G-KNIGHT study

Shigenori Kadowaki, Tomoyuki Otsuka, Keiko Minashi, Shinichi Nishina et autres

BACKGROUND: Nivolumab plus chemotherapy has shown efficacy in clinical trials for advanced or recurrent gastric cancer (GC). However, real-world utilization data are limited. In this study, we aimed to assess the effectiveness, safety, and treatment status of first line nivolumab plus chemotherapy …

jp (code pays fourni par la source)

ONO ‐4578 Plus Nivolumab in Unresectable Advanced or Recurrent Gastric or Gastroesophageal Junction Cancer

Akihito Kawazoe, Kensei Yamaguchi, Tetsuya Hamaguchi, Yukiya Narita et autres

ONO-4578, an EP4 antagonist, alone and combined with nivolumab, showed acceptable safety profiles and signs of antitumor activity in solid tumors. The expansion part examined the safety, preliminary efficacy, and biomarkers of ONO-4578 plus nivolumab in unresectable advanced or recurrent gastric or …

jp (code pays fourni par la source)

Zimberelimab platform study: Safety and efficacy of zimberelimab in combination with futibatinib and chemotherapy in patients with first-line advanced or metastatic esophageal carcinoma.

Shota Fukuoka, Nozomu Machida, Seiichiro Mitani, Shun Yamamoto et autres

409 Background: Zimberelimab: AB122 (Zim) platform study is a Phase 1 a/b study with multiple cohorts designed to evaluate the safety and efficacy of Zim, an anti-PD-1 antibody. Futibatinib (Futi) is an FGFR inhibitor that covalently binds FGFR1–4; FGFR inhibitors have been …

jp (code pays fourni par la source)

Impact of RAS and BRAF heterogeneity on the efficacy of EGFR blockade in patients with metastatic colorectal cancer.

Nobuhisa Matsuhashi, Takeshi Yamada, Takeshi Nagasaka, Kozo Kataoka et autres

255 Background: Epidermal growth factor receptor (EGFR) blockade can effectively shrink tumors in metastatic colorectal cancer (CRC) patients without RAS nor BRAF mutations. However, some patients without RAS or BRAF mutations in their primary tumors may develop these mutations in metastatic tumors …

jp (code pays fourni par la source)

Development of a keratin film-based assay for bacterial removal and adherence, and examination of the influence of fucoidan on skin bacteria

Akihiro Michihara, Chiharu Furukawa, Hiroshi Matsuoka, Satoko Fujioka et autres

The outer layer of the epidermis, called the stratum corneum (SC), comprises keratin-rich cells and intercorneal lipids. Staphylococcus aureus has been linked to the fragility of the stratum corneum and formation of atopic dermatitis (AD) lesions. Thus, binding of keratin to bacteria …

jp, us, pl (code pays fourni par la source)

Peripheral administration of sepiapterin replenishes brain tetrahydrobiopterin

Akiko Ohashi, Eiko Nakamaru‐Ogiso, Hiroshi Matsuoka, Shin Aizawa et autres

jp, us (code pays fourni par la source)

SY8-4 The essence of the Clinical Practice Guidelines for the care of psychologically distressed bereaved families and future prospects

Hiroshi Matsuoka

Real-world treatment costs of first-line treatment for metastatic colorectal cancer: a survey of the JCOG colorectal cancer study group

Atsuo Takashima, Megumi Ishiguro, Keita Sasaki, Ryunosuke Machida et autres

BACKGROUND: Although treatment outcomes for metastatic colorectal cancer (mCRC) have dramatically improved over the past few decades, drug costs have also significantly increased. This study aimed to investigate which first-line treatment regimens for mCRC are actually used (frequency) in Japanese practice and …

us, jp (code pays fourni par la source)