Akihiro Michihara

Corrigendum to “Pharmaceutical optimization of chitosan tablets is associated with reduced circulating bile acids and fibrosis-related molecular signatures in non-alcoholic steatohepatitis rats” [Carbohydrate Polymers 383 (2026) 125333]

Tomoki Adachi, Nowshin Farzana Khan, Akihiro Michihara, Ryo Kaneko et autres

jp (code pays fourni par la source)

Pharmaceutical optimization of chitosan tablets is associated with reduced circulating bile acids and fibrosis-related molecular signatures in non-alcoholic steatohepatitis rats

Tomoki Adachi, Nowshin Farzana Khan, Akihiro Michihara, Ryo Kaneko et autres

jp (code pays fourni par la source)

Construction of a keratinocyte–staphylococci direct contact coculture model for analysis of inflammatory and defense responses regulated by bacterial ratio

Akihiro Michihara, Ryo Kaneko, Daichi Miwa, Hiroshi Matsuoka et autres

Common skin microbiota contribute to host defense and inflammation control, with their effects depending on bacterial species and load along with cell-to-bacteria ratio. However, studies comparing these effects across species in a ratio-dependent manner under identical conditions are limited. This study aimed …

jp (code pays fourni par la source)

Development of a keratin film-based assay for bacterial removal and adherence, and examination of the influence of fucoidan on skin bacteria

Akihiro Michihara, Chiharu Furukawa, Hiroshi Matsuoka, Satoko Fujioka et autres

The outer layer of the epidermis, called the stratum corneum (SC), comprises keratin-rich cells and intercorneal lipids. Staphylococcus aureus has been linked to the fragility of the stratum corneum and formation of atopic dermatitis (AD) lesions. Thus, binding of keratin to bacteria …

jp, us, pl (code pays fourni par la source)

Polypeptides comprising arginine and lysine regulate the microbial balance in seborrheic dermatitis

Akihiro Michihara, Masato Tange, Hiroshi Matsuoka, Fangfang Wang et autres

Malassezia furfur (Mf) and Staphylococcus aureus (Sa) are the causative microorganisms of seborrheic dermatitis (SD). Notably, Staphylococcus epidermidis (Se) inhibits the growth of Sa and secretes moisturizing components. Therefore, suppression of Mf and Sa proliferation and promotion of Se growth are crucial …

jp (code pays fourni par la source)

Selective effects of lysine/arginine-derived peptides, alone or in combination with maltotetraose-containing oligosaccharides, on skin-associated Staphylococcus species

Akihiro Michihara, Daichi Miwa, Hiroshi Matsuoka, Masato Tange et autres

Overgrowth of Staphylococcus aureus (S. aureus) on the skin is associated with the exacerbation of inflammatory skin diseases such as atopic and seborrheic dermatitis. Previously, we used turbidity (OD600) measurments to show that a cationic peptide (Peptiskin, a peptide mixture composed of …

jp (code pays fourni par la source)

Hinokitiol and pyrrolidone carboxylate zinc or corn oligosaccharides: A Synergistic approach to combating scalp microorganisms in seborrheic dermatitis

Akihiro Michihara, Hiroshi Matsuoka, Junichi Fujii, Chiharu Furukawa et autres

Seborrheic dermatitis (SD) is a prevalent condition that results in dandruff, itching, and discomfort, and affect approximately 3–10% of the general population. Proliferation of the genus Malassezia, a microorganism inhabiting the scalp, is considered a contributing factor. Despite reducing the Malassezia population, …

jp (code pays fourni par la source)

Inhibitory effect of mozuku seaweed-derived ultra-high-molecular-weight fucoidan on the growth of indigenous skin bacteria

Hiroshi Matsuoka, Junichi Fujii, Yuka Nagatsuka, Masaya Ohta et autres

Fucoidan, a sulfated polysaccharide found abundantly in brown algae such as mozuku seaweeds, is classified as a water-soluble dietary fiber. Fucoidan reportedly exerts antitumor, anti-inflammatory, immunomodulatory, antioxidant, whitening, antibacterial, and antiviral activities. Owing to these properties, fucoidan has been widely used as …

jp, us (code pays fourni par la source)

EGF-Dependent Activation of ELK1 Contributes to the Induction of CLDND1 Expression Involved in Tight Junction Formation

Hiroshi Matsuoka, Alice Yamaoka, Takahiro Hamashima, Akiho Shima et autres

Claudin proteins are intercellular adhesion molecules. Increased claudin domain-containing 1 (CLDND1) expression is associated with the malignant transformation of estrogen receptor-negative breast cancer cells with low sensitivity to hormone therapy. Abnormal CLDND1 expression is also implicated in vascular diseases. Previously, we investigated …

jp (code pays fourni par la source)

The Effects of Sacran, a Sulfated Polysaccharide, on Gut Microbiota Using Chronic Kidney Disease Model Rats

Miwa Goto, Yusei Kobira, Shinichiro Kaneko, Hidetoshi Arima et autres

The aim of this study was to investigate the beneficial effects of sacran, a sulfated polysaccharide, on renal damage and intestinal microflora, in 5/6 nephrectomy rats as a model for chronic kidney disease (CKD). 5/6 Nephrectomy rats were divided into sacran treated …

jp, us, pl (code pays fourni par la source)

Identification of the RORα Transcriptional Network Contributes to the Search for Therapeutic Targets in Atherosclerosis

Hiroshi Matsuoka, Akihiro Michihara

The retinoic acid receptor-related orphan receptor α (RORα) is involved in the regulation of several physiological processes, including development, metabolism, and circadian rhythm. RORα-deficient mice display profound atherosclerosis, in which hypoalphalipoproteinemia is reportedly associated with decreased plasma levels of high-density lipoprotein, increased …

jp (code pays fourni par la source)

Sacran, a sulfated polysaccharide, suppresses the absorption of lipids and modulates the intestinal flora in non-alcoholic steatohepatitis model rats

Miwa Goto, Kazuo Azuma, Hidetoshi Arima, Shinichiro Kaneko et autres

jp (code pays fourni par la source)