Leila Smith

Case Report: Discordant RT-PCR Results in COVID-19 Patient Challenges Clinical Decisions

Leila Smith, Liam Smyth, Eoin R. Feeney, Kirsten Schaffer et autres

We report a case study of a COVID-19 patient whose PCR results fluctuated from detected to not detected over a period of 3 weeks depending on the PCR assay used and the challenge this presented to clinicians. This is the first report …

First Report of Shot Hole Disease on Cherry Laurel (Prunus laurocerasus) Caused by Micrococcus aloeverae in Ireland

Leila Smith, Hesham A. Y. Gibriel, Ciarán J. Brennan, M. del Pino de Elias et autres

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Leila Smith

Interleukin‐4 and interleukin‐13 evoke scratching behaviour in mice

Michelle Campion, Leila Smith, S. Gatault, Charles Métais et autres

Persistent and relapsing itch commonly manifests in inflammatory skin disorders such as atopic dermatitis (AD). AD pathogenesis is driven by interleukin-4 (IL-4) and interleukin-13 (IL-13). Dupilumab, a monoclonal antibody blocking the action of IL-4 and IL-13 effectively reduces the symptoms of AD …

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House dust mite‐treated PAR2 over‐expressor mouse: A novel model of atopic dermatitis

Leila Smith, S. Gatault, Laura Casals‐Diaz, Pamela Kelly et autres

BACKGROUND: Atopic dermatitis (AD) is a complex skin disease involving causative effects from both intrinsic and extrinsic sources. Murine models of the disease often fall short in one of these components and, as a result, do not fully encapsulate these disease mechanisms. …

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Leila Smith

Research Guides: Ivy Plus Libraries Resource Sharing Fall Meeting: Traveling to Harvard

Leila Smith

Pharmacologic inhibition of hypoxia‐inducible factor (HIF)‐hydroxylases ameliorates allergic contact dermatitis

Mario C. Manresa, Leila Smith, Laura Casals‐Diaz, Raphael R. Fagundes et autres

BACKGROUND: When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. The hypoxia-inducible factor-1α (HIF-1α) promotes an adaptive transcriptional response to hypoxia …

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657 Characterisation of a novel murine model of atopic dermatitis

Leila Smith, S. Gatault, Laura Casals‐Diaz, Charles Métais et autres

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Epstein-Barr Virus DNA Viral Loads: Is There a Correlation Between Paired Whole Blood and Plasma Collected from a Cohort of Pediatric Renal Transplant Patients?

Jaythoon Hassan, Leila Smith, Michael Riordan, Clodagh Sweeney et autres

Monitoring of Epstein-Barr virus DNA viral loads (EBVL) in whole blood and plasma following pediatric kidney transplantation has been routinely employed to facilitate the diagnosis and management of Epstein-Barr virus (EBV) infection. However, recent studies from our laboratory and others have demonstrated …

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268 Expression of Interleukin-33 by resident and immune cells in the skin of patients with atopic dermatitis

Leila Smith, Barry Moran, Helen Rea, Mathilde Raverdeau et autres

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Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells, and impacts on MEK and TRAIL protein expression

Sinéad Aherne, Paul Smyth, Michael Freeley, Leila Smith et autres

Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer-related deaths each year. Our group and others have previously demonstrated dysfunctional microRNA (miRNA or miR) expression in the context of thyroid cancer. The objective of the …

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