Paul Smyth

Prevalence of BRCA1/2 variants in an Ovarian Cancer Cohort: outcomes from a Nationwide Testing Program

Ciara S. McNevin, Kate Murphy, Pierre Murchan, Andrea Hennessy et autres

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CircRNA signatures to identify candidate biomarkers of treatment resistance in BRCA1 -mutant ovarian cancer.

Ciara S. McNevin, Josh Flynn, Martin P. Barr, Sharon O’Toole et autres

e17558 Background: Most patients with high grade serous ovarian cancer (HGSOC) ultimately relapse with chemotherapy resistant disease, and resistance to Poly (ADP ribose) polymerase inhibitors (PARPi) is increasingly recognised. The mechanisms underlying inherent and acquired resistance remain poorly understood, and no validated …

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circRNA signatures associated with BRCA mutation status in ovarian cancer and a RASSF8-derived candidate biomarker.

Ciara S. McNevin, Josh Flynn, Martin P. Barr, Sharon O’Toole et autres

e17548 Background: Clinically actionable variants (CAVs) in BRCA1 and BRCA2 determine eligibility for targeted therapy in high grade serous ovarian cancer (HGSOC). However, RNA based biomarkers indicating BRCA status remain limited. Circular RNAs (circRNAs) are non coding RNAs with regulatory roles in …

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Prevalence Of BRCA1/2 In An Ovarian Cancer Cohort: Outcomes From A Nationwide Testing Program

Ciara S. McNevin, Rachel Dillion, Pierre Murchan, Órla Fitzpatrick et autres

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Electroconvulsive Stimulation in Rats Induces Alterations in the Hippocampal miRNome: Translational Implications for Depression

Karen M. Ryan, Paul Smyth, Gordon Blackshields, Laura Kranaster et autres

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The induction of a mesenchymal phenotype by platelet cloaking of cancer cells is a universal phenomenon

Cathy Spillane, Niamh Cooke, Mark P. Ward, Dermot Kenny et autres

Tumour metastasis accounts for over 90% of cancer related deaths. The platelet is a key blood component, which facilitates efficient metastasis. This study aimed to understand the molecular mechanisms involved in tumour-platelet cell interactions. The interaction between cancer cells and platelets was …

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Prostate cancer-derived holoclones: a novel and effective model for evaluating cancer stemness

Louise Flynn, Martin P. Barr, Anne‐Marie Baird, Paul Smyth et autres

Prostate cancer accounts for approximately 13.5% of all newly diagnosed male cancer cases. Significant clinical burdens remain in terms of ineffective prognostication, with overtreatment of insignificant disease. Additionally, the pathobiology underlying disease heterogeneity remains poorly understood. As the role of cancer stem …

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Potentially important miRNAs in enteropathy-associated T-cell lymphoma pathogenesis: A pilot study

Lindsey Clarke, Sitaramaraju Adduri, Paul Smyth, Fiona Quinn et autres

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A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance

Soracha E. Ward, Jamie M. O’Sullivan, Clive Drakeford, Sonia Águila et autres

mice compared with controls. Collectively, these findings identify MGL as a novel macrophage receptor for VWF that significantly contributes to the clearance of both wild-type and hyposialylated VWF.

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Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project

Igor Letovanec, Stephen P. Finn, Panagiota Zygoura, Paul Smyth et autres

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miR-223 potentially targets SWI/SNF complex protein SMARCD1 in atypical proliferative serous tumor and high-grade ovarian serous carcinoma

Florence A. Arts, Lisa Keogh, Paul Smyth, Sharon O’Toole et autres

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Peripheral blood micro RNA and VEGFA mRNA changes following electroconvulsive therapy: implications for psychotic depression

Erik Kolshus, Karen M. Ryan, Gordon Blackshields, Paul Smyth et autres

OBJECTIVE: MicroRNAs are short, non-coding molecules that regulate gene expression. Here, we investigate the role of microRNAs in depression and electroconvulsive therapy (ECT). METHODS: We performed three studies: a deep sequencing discovery-phase study of miRNA changes in whole blood following ECT (n …

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