Design and Validation of a Patient-Specific Stereotactic Frame for Transcranial Ultrasound Therapy
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Le résumé fourni par la source
Transcranial-focused ultrasound (tFUS) procedures such as neuromodulation and blood-brain barrier (BBB) opening require precise focus placement within the brain. MRI is currently the most reliable tool for focus localization but can be prohibitive for procedures requiring recurrent therapies. We designed, fabricated, and characterized a patient-specific, 3-D-printed, stereotactic frame for repeated tFUS therapy. The frame is compact, with minimal footprint, can be removed and re-secured between treatments while maintaining sub-mm accuracy, and will allow for precise and repeatable transcranial FUS treatment without the need for MR-guidance following the initial calibration scan. Focus localization and repeatability were assessed via MR-thermometry and MR-acoustic radiation force imaging (ARFI) on an ex vivo skull phantom and in vivo nonhuman primates (NHPs), respectively. Focal localization, registration, steering, and re-steering were accomplished during the initial MRI calibration scan session. Keeping steering coordinates fixed in subsequent therapy and imaging sessions, we found good agreement between steered foci and the intended target, with target registration error (TRE) of 1.2 ± 0.3 ( n = 4 , ex vivo) and 1.0 ± 0.5 ( n = 3 , in vivo) mm. Focus position (steered and non-steered) was consistent, with sub-mm variation in each dimension between studies. Our 3-D-printed, patient-specific stereotactic frame can reliably position and orient the ultrasound transducer for repeated targeting of brain regions using a single MR-based calibration. The compact frame allows for high-precision tFUS to be carried out outside the magnet and could help reduce the cost of tFUS treatments where repeated application of an ultrasound focus is required with high precision.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Design and Validation of a Patient-Specific Stereotactic Frame for Transcranial Ultrasound Therapy
- Date Crossref
- 01/08/2024
- Éditeur
- Institute of Electrical and Electronics Engineers (IEEE)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Vanderbilt University Medical Center pays non établi dans la noticeÉtablissement de santé
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Vanderbilt University Vanderbilt Institute for Surgery and Engineering (VISE) pays non établi dans la noticeUniversité ou école supérieure
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West Virginia University Rockefeller Neuroscience Institute pays non établi dans la noticeUniversité ou école supérieure
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Blanchette Rockefeller Neurosciences Institute pays non établi dans la noticeOrganisation à but non lucratif
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Department of Biomedical Engineering pays non établi dans la noticeInstitution
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VUIIS pays non établi dans la noticeInstitution
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Department of Electrical and Computer Engineering and VISE pays non établi dans la noticeInstitution
Vanderbilt University Medical Center, Vanderbilt Institute for Surgery and Engineering (VISE) — Vanderbilt University et Rockefeller Neuroscience Institute — West Virginia University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.