Cemil Bilir

Clinical Characteristics, Treatment Patterns, and Survival Outcomes of Right-Sided RAS/RAF Wild-Type Metastatic Colorectal Cancer: A Real-World Multicenter Cohort Study

Nur Deniz Yildiz, Çağatay Arslan, İlker Ökten, Umut Kefeli et autres

Background: Right-sided metastatic colon cancer represents a clinically distinct subgroup with inferior outcomes and uncertain optimal biologic treatment selection, even among patients with RAS wild-type disease. Real-world data focusing specifically on right-sided RAS wild-type metastatic colon cancer remain limited. This study aimed …

tr, ag, us (code pays fourni par la source)

Real-world outcomes of first-line treatments in patients with metastatic non-small cell lung cancer: Final analysis of the Registurk-Lung registry.

Sema Sezgin Goksu, Mehmet Artac, Ahmet Sezer, Abdurrahman Işıkdoğan et autres

e20633 Background: Real-world data are critical to understanding treatment patterns and outcomes in metastatic non–small cell lung cancer (mNSCLC) outside clinical trials. The REGISTURK-LUNG registry was designed to evaluate demographic, clinicopathological characteristics, treatment strategies, and survival outcomes of patients with mNSCLC treated …

tr (code pays fourni par la source)

Implementation of a 1021-gene liquid biopsy assay for real-world tumor genomic profiling in oncology practice

Chrysiida Florou-Chatzigiannidou, Eirini Papadopoulou, Vasiliki Metaxa-Mariatou, Aikaterini Tsantikidi et autres

The application of advanced next-generation sequencing (NGS) technologies in the analysis of circulating tumor DNA (ctDNA) enabled the comprehensive evaluation of tumor-derived alterations in the bloodstream. In this study, we evaluated the analytical performance and clinical utility of a large-scale liquid biopsy …

gr, ro, tr, gb, lb (code pays fourni par la source)

Real-world practices in RAS wild-type metastatic colorectal cancer patients treated with targeted agents in the first-line a nationwide onco-colon Turkey registry

Dilek Tatlıdede, Cagatay Arslan, Mahmut Emre Yıldırım, Abdurrahman Işıkdoğan et autres

Aim: Efficacy of antiepidermal growth factor receptor (anti-EGFR) agents has been demonstrated in metastatic colorectal cancer (mCRC). Real-world evidence is especially important to detect patient findings outside of clinical trials. Therefore; we aimed to investigate the real-world data in patients with RAS …

tr, ag, in, es (code pays fourni par la source)

Real-World Survival Outcomes Following Metastasectomy in RAS Wild-Type mCRC: Insights from a Multicentre National Cohort Study

İlker Ökten, Tuba Baydaş, Mahmut Emre Yıldırım, Cemil Bilir et autres

Background: Metastasectomy is a cornerstone of multimodal management in metastatic colorectal cancer (mCRC), yet contemporary real-world data focusing specifically on RAS wild-type (RAS-WT) disease remain limited. We aimed to evaluate survival outcomes and prognostic factors associated with metastasectomy in patients with RAS-WT …

tr, us, ag (code pays fourni par la source)

Factors affecting inflammatory markers in neutropenic patients with bacteremia: An international ID-IRI study

Hakan Erdem, Gülden Eser Karlıdağ, Ahmet Naci Emecen, Rehab El-Sokkary et autres

tr, ag, Égypte, ir, bg, ro, bh, kz, us, it, hr (code pays fourni par la source)

Dual inhibition of ATR and PARP reverses acquired PARP inhibitor resistance in triple negative breast cancer

Gamze Güney Eskiler, Ayten Haciefendi, Kayhan Özdemir, Cemil Bilir

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) have attracted significant attention in triple negative breast cancer (TNBC) treatment. However, the acquired or de novo PARP inhibitor resistance limits treatment success. Ataxia telangiectasia and Rad3-related (ATR) regulates genome integrity, and thus, the aberrant activation of …

tr (code pays fourni par la source)

The Anticancer Potential of Chlorine Dioxide in Small-Cell Lung Cancer Cells

S. Zeki Yıldız, Cemil Bilir, Gamze Güney Eskiler, Filiz Bilir

[This retracts the article DOI: 10.7759/cureus.29989.].

tr (code pays fourni par la source)

Exploring patient centered communication on health outcomes: Role of trust and online information seeking in Turkish cancer patients receiving chemotherapy

Ersin Eskiler, Cemil Bilir, Remzi Altunışık

BACKGROUND: Patient-centered communication (PCC) is an important concept at the core of patient-centered care. PCC can help physicians understand patients’ needs, provide adequate information to patients, and establish trust between patients and physicians, thus promoting satisfaction with information received and perceived quality …

tr (code pays fourni par la source)

P2.10.02 Developments in Treatment of Non-Small Cell Lung Cancer and Their Implications for National Practice.Registurk-Lung National Registry Study

İlhan Hacıbekiroğlu, Erdem Çubukçu, Tülay Kuş, İbrahim Vedat Bayoğlu et autres

tr, kw, ag (code pays fourni par la source)

Comprehensive Evaluation of a 1021-Gene Panel in FFPE and Liquid Biopsy for Analytical and Clinical Use

Angeliki Meintani, Mustafa Özdoğan, Nikolaos Touroutoglou, Konstantinos Papazisis et autres

In the era of precision oncology, comprehensive molecular profiling is critical for guiding targeted and immunotherapy strategies. This study presents the analytical and clinical validation of a 1021-gene next-generation sequencing (NGS) panel, designed for use with both formalin-fixed paraffin-embedded (FFPE) tissue- and …

gr, tr (code pays fourni par la source)

KRAS Mutasyonu Saptanmayan Metastatik Kolorektal Kanserli Hastalarda Anti-EGFR Kullanımı-Ulusal Onco-Colon Çalışması Gerçek Yaşam Verleri

Dilek Tatlıdede, Çağatay Arslan, Mahmut Emre Yıldırım, Abdurrahman Işıkdoğan et autres