Jingxian Zhu

Circadian disruption accelerates the progression of experimental periodontitis via PER2/miR-21-mediated inflammatory and osteogenic dysregulation

Yiran Li, Jingxian Zhu, Nianke Liu, Xin Wang et autres

Periodontitis is a chronic inflammatory disease characterized by progressive alveolar bone destruction and represents a major cause of tooth loss. It has also been associated with systemic inflammatory conditions such as diabetes. Circadian rhythms, governed by clock genes, are essential for maintaining …

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Expert consensus on the diagnosis and management of tooth developmental anomalies

Jingxian Zhu, Mian Wan, Xiaohong Duan, Zhipeng Fan et autres

Tooth developmental anomalies are a group of disorders caused by unfavorable factors affecting the tooth development process, resulting in abnormalities in tooth number, structure, and morphology. These anomalies typically manifest during childhood, impairing dental function, maxillofacial development, and facial aesthetics, while also …

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Differences in Body Composition and Lower Limb Strength Between Novice and Amateur Marathon Runners: A Cross-Sectional Study

Qingzhao Shi, Shuang Ren, Jun Ren, Xin Gao et autres

This study compared the body composition and strength of the lower extremity parameters between novice runners (NRs) and amateur marathon runners (AMRs). A total of 50 NRs (33.84 ± 4.32 years) and 50 AMRs (33.36 ± 5.55 years) were analyzed cross-sectionally. Bioelectrical …

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Corrigendum to “Wireless power supply near-infrared light drug-loaded microneedle system for the treatment of linear skin wounds” [Chem. Eng. J. (2024) 157110/1385–8947]

Xiaoning Zhang, Jingxian Zhu, Xiaoya Kang, Xiaoqing Hu et autres

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Intelligent Diagnosis of Cervical Lymph Node Metastasis Using a CNN Model

Ximing Xu, Linlin Xi, Jingxian Zhu, Chen Feng et autres

Lymph node (LN) metastasis is a prevalent cause of recurrence in oral squamous cell carcinoma (OSCC). However, accurately identifying metastatic LNs (LNs+) remains challenging. This prospective clinical study aims to test the effectiveness of our convolutional neural network (CNN) model for identifying …

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Long‐Term Clinical Outcomes and Risk Indicator Analyses of Narrow‐Diameter Implants in the Posterior Jaw: A Retrospective Cohort Study of 10 to 27 Years

Jingxian Zhu, Wei Sun, Shanyi Yang, Zhili Du et autres

OBJECTIVES: To assess the long-term clinical outcomes and patient satisfaction with narrow-diameter implants (NDIs) in the posterior jaws and to identify the risk indicators for NDI failure. MATERIALS AND METHODS: This retrospective study reviewed 479 patients with 666 NDIs (diameter ≤ 3.5 …

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Wireless power supply near-infrared light drug-loaded microneedle system for the treatment of linear skin wounds

Xiaoning Zhang, Jingxian Zhu, Xiaoya Kang, Xiaoqing Hu et autres

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Jawbone periosteum‐derived cells with high osteogenic potential controlled by R‐spondin 3

Shu Zhang, Jingxian Zhu, Siyu Jin, Wei Sun et autres

The jawbone periosteum, the easily accessible tissue responding to bone repair, has been overlooked in the recent development of cell therapy for jawbone defect reconstruction. Therefore, this study aimed to elucidate the in vitro and in vivo biological characteristics of jawbone periosteum-derived …

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High-Throughput Preosteoblastic Spheroids Elevate Fibroblast Growth Factor 23 via Parathyroid Hormone Signaling Pathway

Jie Jiang, Jingxian Zhu, Haojie Lin, Siyu Jin et autres

Fibroblast growth factor 23 (FGF23) plays a crucial role in managing renal phosphate and the synthesis of 1,25(OH)2-vitamin D3, which is essential for bone homeostasis. Developing robust in vitro systems to study FGF23-regulating mechanisms is crucial for advancing our knowledge and identifying …

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Downregulation of TGF-β1 in fibro-adipogenic progenitors initiates muscle ectopic mineralization

La Li, Dai Li, Jingxian Zhu, Yiqun Wang et autres

In previous studies, we have demonstrated that stress response-induced high glucocorticoid levels could be the underlying cause of traumatic heterotopic ossification (HO), and we have developed a glucocorticoid-induced ectopic mineralization (EM) mouse model by systemic administration of a high dose of dexamethasone …

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Targeting RIP3 inhibits osteoarthritis development by restoring anabolic-catabolic balance in the bone-cartilage unit

Jin Cheng, Cheng Wang, Jingxian Zhu, La Li et autres

Osteoarthritis (OA) is a debilitating joint disorder characterized by progressive cartilage degeneration. During OA, subchondral bone undergoes microstructural and molecular changes that precede cartilage degradation. However, specific mechanisms underlying metabolic dysregulation of the bone-cartilage unit remain unclear. This study aims to investigate …

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Wireless Power Supply Near-Infrared Light Drug-Loaded Microneedle System for the Treatment of Linear Skin Wounds

Xiaoning Zhang, Jingxian Zhu, Xiaoya Kang, Xiaoqing Hu et autres

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