Timothy J. Humpton

Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis

Celine I Wittke, Dale M. Watt, Liam Butler, Anabel Martinez Lyons et autres

ABSTRACT Background & aims TP53 (p53) coordinates diverse cellular stress response programmes including pro-survival activities, senescence, and cell death. During tissue damage, p53 can shape both the local cellular response to injury, including the fibrotic response, and influence distal organ biology. Fibrosis …

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LIMK Inhibition and Metformin Block Mitochondrial Transfer Overcoming Macrophage Driven Therapy Resistance in Acute Myeloid Leukaemia

Ebubechukwu Nwarunma, Katerina E. Miari, Athanasia Papadopoulou, Stefan Corradini et autres

ABSTRACT Chemoresistance is a major contributor to poor clinical outcomes in AML patients and can arise from interactions between AML cells and the bone marrow microenvironment (BME). How immune cells, particularly macrophages (Mφs), facilitate this process requires better clarification. This study shows …

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p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

Celine I Wittke, Eric C. Cheung, Dimitris Athineos, Nicola Clements et autres

Background & Aims TP53 is a potent tumour suppressor that coordinates diverse stress response programmes, ranging from pro-survival activities to cell death. p53 is also engaged during tissue damage and repair, including within the liver. Metabolic dysfunction-associated steatohepatitis (MASH) is a major …

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M2-like Macrophages Transfer Mitochondria to Acute Myeloid Leukaemia Cells Via Tunnelling Nanotubes Promoting Therapy Resistance

Ebubechukwu Nwarunma, Katerina E. Miari, Athanasia Papadopoulou, Leandro Marcelo Martinez et autres

Introduction: The bone marrow microenvironment actively drives therapy resistance in AML. Leukaemic cells interact with bone marrow (BM) resident stromal cells and immune cells, such as macrophages (Mφs). M2-like Mφs are elevated in the BM of AML patients, and transfer their mitochondria …

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p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

Celine I Wittke, Eric C. Cheung, Dimitris Athineos, Nicola Clements et autres

ABSTRACT TP53 is a potent tumour suppressor that coordinates diverse stress response programmes within the cell. The activity of p53 is frequently context and cell type-dependent, and ranges from pro-survival activities, including the implementation of transient cell cycle arrest and metabolic rewiring, …

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The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

Deborah R. Caswell, Philippe Gui, Manasi K. Mayekar, Emily K. Law et autres

In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. A3B expression in EGFR mutant (EGFRmut) non-small-cell lung cancer (NSCLC) mouse models constrained tumorigenesis, while A3B …

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Data from Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Timothy J. Humpton, Brinda Alagesan, Gina M. DeNicola, Dan Lu et autres

Abstract Activating KRAS mutations are found in nearly all cases of pancreatic ductal adenocarcinoma (PDAC), yet effective clinical targeting of oncogenic KRAS remains elusive. Understanding of KRAS-dependent PDAC-promoting pathways could lead to the identification of vulnerabilities and the development of new treatments. …

Figure S7 from Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Timothy J. Humpton, Brinda Alagesan, Gina M. DeNicola, Dan Lu et autres

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Figure S4 from Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Timothy J. Humpton, Brinda Alagesan, Gina M. DeNicola, Dan Lu et autres

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Figure S4 from Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Timothy J. Humpton, Brinda Alagesan, Gina M. DeNicola, Dan Lu et autres

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Figure S7 from Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Timothy J. Humpton, Brinda Alagesan, Gina M. DeNicola, Dan Lu et autres

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Figure S5 from Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Timothy J. Humpton, Brinda Alagesan, Gina M. DeNicola, Dan Lu et autres

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