Yuzuru Ikehara

Hypoxia-Induced Epas1-Myl9/12 Axis Shapes the Pathology of Pulmonary Hypertension

Sachiko Kuriyama, Chiaki Iwamura, Masahiro Kiuchi, Tetsutaro Nagaoka et autres

BACKGROUND: Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder characterized by vascular remodeling, abnormal vasoconstriction of small lung arteries, and right heart failure. Hypoxia causes vascular damage, leading to vessel stenosis or occlusion by aberrant endothelial cells, hypertrophy of the tunica media, …

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Genetic and clinical characteristics of Japanese cystinuria with exon and exon–intron boundary variants

Shinichi Sakamoto, Yukio Naya, Junryo Rii, Kazumi Taguchi et autres

AT will cause Cystinuria. The current work analyzed the clinical and genetic characteristics of Japanese Cystinuria patients. In total, 101 Cystinuria patients were studied. Clinical phenotypes were defined, and genetic analysis of SLC3A1 and SLC7A9 was performed by next-generation sequencing. Excretion of …

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Increased expression of the PIEZO2 mechanoreceptor in fibroblasts and endothelial cells within the lymphatic and vascular vessels of keloids

Shinsuke Akita, Sanae Ikehara, Masahiro Kiuchi, Kota Kokubo et autres

Keloids are scars that grow abnormally due to excessive extracellular matrix production by fibroblasts and increased angiogenesis. Chronic tension is implicated in their growth, but the exact pathology remains unclear. This study investigated the increased expression of molecules responsible for sensing pressure …

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Ultrastructural Analysis of Infected Absorbable Bone Fixation Material Using Scanning Electron Microscopy After Zygomatic Bone Fracture Surgery

Mizuna Aisawa, Yoshitaka Kubota, Kazuhiko Azuma, Syota Ohki et autres

infection 2.5 months after zygomatic bone fracture surgery and the ultrastructure of an infected absorbable plate observed under a scanning electron microscope (SEM). The patient sustained a right zygomatic bone fracture due to a fall and underwent open reduction and internal fixation …

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Author Correction: The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2

Maihulan Maimaiti, Shinichi Sakamoto, Masahiro Sugiura, Manato Kanesaka et autres

As a result of an error during figure assembly, the Article contained a duplication of Fig. 1 C 4F2hc in Fig. 1D 4F2hc. Since the original data for Fig. 1 D was not available the Authors repeated the experiments, and Fig. 1 …

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Seasonal activities, morphological characteristics, and veterinary importance of Haemaphysalis mageshimaensis in Ishigaki and Yonaguni, Okinawa, Japan

Satoko NAKAO, Thillaiampalam Sivakumar, Hajime Suzuki, Keiichiro Ohta et autres

Ticks are of veterinary importance as they transmit various pathogens to animals. In Yaeyama, Okinawa, Japan, Haemaphysalis longicornis became the dominant tick species after the eradication of Rhipicephalus (Boophilus) microplus in the 1990s. However, any recent changes remained unclear due to lack …

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Medical Applications of Atmospheric Pressure Plasma, Material Processing Using Quasi-Atmospheric Pressure Plasma

Hajime Sakakita, Yuzuru Ikehara

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Genetic and Clinical Characteristics of Japanese Cystinuria with Exon and Exon-Intron Boundary Variants

Shinichi Sakamoto, Yukio Naya, Junryo Rii, Kazumi Taguchi et autres

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Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients

Ami Aoki, Chiaki Iwamura, Masahiro Kiuchi, Kaori Tsuji et autres

PURPOSE: Auto-antibodies (auto-abs) to type I interferons (IFNs) have been identified in patients with life-threatening coronavirus disease 2019 (COVID-19), suggesting that the presence of auto-abs may be a risk factor for disease severity. We therefore investigated the mechanism underlying COVID-19 exacerbation induced …

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Application and Evaluation of Plasma Generated by Asymmetric Surface Discharge on the Ceramic Surface to Hemostatic Equipment

Emiri Yamamoto, Shinsuke Akita, Kazuhiko Azuma, Syota Ohki et autres

The use of plasma-based processes has been growing in the manufacturing and processing materials through advances in discharge technology. We sought to investigate whether plasma generation units of an asymmetric surface dielectric barrier discharge (AS-GDBD) could be used as hemostatic devices based …

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Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer

Hayato Ota, Hirokazu Sato, Shuji Mizumoto, Ken Wakai et autres

Androgen deprivation therapy is given to suppress prostate cancer growth; however, some cells continue to grow hormone-independently as castration-resistant prostate cancer (CRPC). Sulfated glycosaminoglycans promote ligand binding to receptors as co-receptors, but their role in CRPC remains unknown. Using the human prostate …

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Increased Myosin light chain 9 expression during Kawasaki disease vasculitis

Hironobu Kobayashi, Motoko Y. Kimura, Ichita Hasegawa, Eisuke Suganuma et autres

Introduction: Kawasaki disease (KD) is an acute systemic vasculitis that predominantly afflicts children. KD development is known to be associated with an aberrant immune response and abnormal platelet activation, however its etiology is still largely unknown. Myosin light chain 9 (Myl9) is …

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