Danijela M. Mišić

Comparative Phytochemical Characterization and Bioactivity Profiling of Serbian Ajuga Species from Different Localities: Antioxidant, Antityrosinase, Antimicrobial and Anti-Pyocyanin Activities

Ana M. Džamić, Jelena S. Matejić, Ksenija S. Mileski, Lazar D. Žarković et autres

Herbaceous and subshrub species of the genus Ajuga are recognized as valuable sources of bioactive metabolites with diverse pharmacological properties. This study comparatively evaluated the phytochemical composition and the in vitro biological activities of Ajuga chamaepitys, A. genevensis, A. laxmannii, and A. …

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Towards Understanding the Bioactive Potential of Two Intriguing Nepeta Species: Metabolomic and Phylogenetic Perspectives

Uroš M. Gašić, Tijana Banjanac, Luka Petrović, Jovana D. Petrović et autres

Nepeta govaniana and Nepeta subsessilis display metabolomes typical for the genus Nepeta L. (Lamiaceae), predominated by monoterpenoid iridoids and phenolic acids. Underexplored phytochemical composition and largely undefined biological potential are the main reasons for the underutilized status of these two intriguing species. …

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Evidence-driven m/z alignment in mass spectrometry imaging: Physics models, observed-data recalibration, and deep learning

Kai Cheng, Danijela M. Mišić, Marina Sokóvić, Daniel Figeys et autres

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A Depth-Controlled Longitudinal Cutting Strategy Enhances MALDI-MSI of Entire Leaves

Ying Chen, Chunping Tang, Jian Hua Sui, Jie Yuan et autres

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) enables spatial analysis of endogenous metabolites in plant leaves, contributing to insights into the complex chemical, spatial, and temporal variations in plant metabolism. Longitudinal sectioning can offer rich information about tissue heterogeneity and molecular distribution …

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Potential genotoxicity of Salvia pratensis L. aqueous extracts and their biogenic silver nanoparticles

Marina Radović Jakovljević, Jovana Tubić Vukajlović, Nikola Z. Srećković, Uroš M. Gašić et autres

Biosynthesis of metal nanoparticles using plant extracts is considered an eco-friendly approach with promisingbiomedical applications; however, data on their safety, particularly genotoxicity, remain limited. This study evaluated thephenolic composition and genotoxic potential of aqueous extracts from the root (SPR) and aerial parts …

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Temporal Tracking of Metabolomic Shifts in In Vitro-Cultivated Kiwano Plants: A GC-MS, LC-HRMS-MS, and In Silico Candida spp. Protein and Enzyme Study

Mladen Rajaković, Jelena Božunović, Danijela M. Mišić, Ivana V. Sofrenić et autres

Cucumis metuliferus E. Mey or kiwano/African horned melon is a good source of bioactive compounds of various pharmacological and industrial importance. This study investigated metabolomic shifts in in vitro cultivated kiwano plants over ten weeks of maturity time through GC-MS and LC-HRMS-MS …

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Therapeutic Potential of Salvia rosmarinus: Seasonal and Geographical Variation in Phytochemical Composition, Bioactivity, and Synergistic Effects of Rosmarinic Acid with 5-FU

Mariana Oalđe Pavlović, Milena G. Milutinović, Ana Alimpić Aradski, Uroš M. Gašić et autres

Salvia rosmarinus Spenn. (rosemary) is a medicinal and aromatic plant of notable pharmacological value. This study evaluated the therapeutic properties of rosemary leaves collected from two Serbian continental (L1, L2) and one Montenegrin Mediterranean (L3) locations, harvested in November (N), March (M), …

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Recent Advances in On‐Tissue Chemical Derivatization Strategies for Enhancing MALDI‐MSI

Mengyuan Huang, Xin Qi, Dafu Zhu, Hao Zhou et autres

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has rapidly advanced in biomedical research, enabling label-free, untargeted spatial detection of metabolites, lipids, proteins, and glycans in tissue sections. However, challenges such as low ionization efficiency and chemical instability limit the detection of certain …

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Valorization of Waste from Bell Pepper: Chemical Composition and Bioactive Potential

Jozias Baessa, Ângela Liberal, Tiane Cristine Finimundy, Dejan S. Stojković et autres

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Oral administration of the probiotic strain Lactobacillus helveticus BGRA43 reduces high-fat diet–induced hepatic steatosis in mice and restores gut microbiota composition

Ana Teofilović, Miloš Vratarić, Biljana N. Bursać, Ljupka Gligorovska et autres

Introduction The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly increasing. Modulation of the gut microbiota through the use of probiotics has been recognized as an important option for the treatment of hepatic steatosis. Previous studies suggested that the bacterial …

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Variation in Brown Rot Susceptibility and Phenolic Profile at Different Stages of Plum Fruit ( Prunus domestica L.) Development

Jovana Hrustić, Brankica Pešić, Milica Mihajlović, Darko Jevremović et autres

Plum production is severely affected by brown rot caused by Monilinia spp. In this study, the relationship between the content of major phenolic compounds and the severity of brown rot in artificially inoculated fruits of two plum cultivars (“Stanley” and “Čačanska Rodna”) …

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The Application of Recycled Jute Non-woven Material Loaded with Zinc Ions as Substrates for Plant Growth

Aleksandar Kovačević, Darka Marković, Slavica Dmitrović, Jasmina Nestorović Živković et autres

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