A.D. Makatsariya

The silent legacy of venous thromboembolism: why rehabilitation is the missing link

D. V. Blinov, A. G. Solopova, V.O. Bitsadze, J.Kh. Khizroeva et autres

Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), remains a global health challenge. Modern advances in the management of acute VTE, such as the introduction of direct oral anticoagulants and interventional techniques, have led to a significantly decreased …

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Cerebral venous thrombosis in pregnancy and use of assisted reproductive technologies. Management strategies

V.O. Bitsadze, S.V. Akinshina, J.Kh. Khizroeva, M. V. Tretyakova et autres

Cerebral venous thrombosis (CVT) is a rare but potentially life-threatening condition that most commonly develops in reproductive-aged women. The main triggering factors are pregnancy, postpartum period and the use of estrogen-containing hormonal agents, including in assisted reproductive technologies (ART). The clinical presentation …

Vaccine-induced immune thrombotic thrombocytopenia: pathogenesis, diagnosis, treatment

A.D. Makatsariya, V.O. Bitsadze, J.Kh. Khizroeva, M. V. Tretyakova et autres

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but severe immunopathological condition that develops primarily after adenoviral vector-based vaccines (ChAdOx1 nCoV-19, Ad26.COV2.S). The pathogenesis is based on the production of autoantibodies to PF4, which cause platelet activation and thrombosis of atypical locations. …

Immune and infection-associated forms of neonatal thrombosis. The role of antiphospholipid syndrome (APS), catastrophic APS, vaccine-induced immune thrombotic thrombocytopenia, and COVID-19

V.O. Bitsadze, J.Kh. Khizroeva, M. V. Tretyakova, N.A. Makatsariya et autres

This article discusses immune and infection-associated forms of neonatal thrombosis, including antiphospholipid syndrome (APS), catastrophic APS (CAPS), COVID-19-associated thrombosis, and vaccine-induced immune thrombotic thrombocytopenia (VITТ)-like conditions. Special attention is paid to the role of de novo synthesis of antiphospholipid and anti-PF4 antibodies …

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Hereditary and acquired thrombophilia in a patient with endometrial adenocarcinoma

Ekaterina V. Slukhanchuk, Victoria O. Bitsadze, А. Г. Солопова, Jamilya Kh. Khizroeva et autres

This article presents a clinical case of a 46-year-old patient with aggravated obstetric and gynecological history, personal and family thrombotic history, who underwent surgery for endometrial adenocarcinoma complicated by the development of pulmonary embolism. The examination revealed hereditary and acquired forms of …

Congenital connective tissue dysplasia and obstetric risks

A.D. Makatsariya, L. S. Radetskaya, V.O. Bitsadze, Jamilya Kh. Khizroeva et autres

Congenital connective tissue diseases are numerous disorders that are associated with connective tissue pathology, involving different organs and systems: musculoskeletal, cardiovascular, ocular, etc. Objective. To study the features of pregnancy course in patients with mesenchymal connective tissue dysplasias. Patients and methods. The …

Obstetric and perinatal risks in patients with von Willebrand disease

A.D. Makatsariya, F.E. Yagubova, Arina V. Lazarchuk, Polina Salnikova et autres

This lecture is devoted to a common inherited hemorrhagic disorder, von Willebrand disease (vWD). The article presents the history of the discovery of vWD, the structure and function of von Willebrand factor (vWF), the classification of vWD and its main clinical manifestations. …

P-056 Molecular mechanisms and different clinical manifestations of APS

D.K. Khizroeva, V.O. Bitsadze, A.D. Makatsariya

11 Evaluation of the preconception treatment in prevention of recurrent preeclampsia

V.O. Bitsadze, A.D. Makatsariya, S.V. Akinshina