Ana Werneck Capuano

Telephone-based Hopkins Verbal Learning Test-Revised as a pre-screening tool for identifying SuperAgers

Justyna Piszczor, Elena Badillo Goicoechea, Rhiana Schafer, Hannah Peirce et autres

OBJECTIVE: Efficient remote screening is needed to identify adults aged ≥80 years with exceptional memory, an uncommon phenotype relevant to cognitive-resilience research, before resource-intensive in-person evaluation. This study examined the optimal telephone-administered episodic-memory cutoff for identifying individuals likely to meet the in-person …

us (code pays fourni par la source)

SuperAging is not the inverse of common-variant Alzheimer’s risk: evidence across genetic ancestries

Ignazio Stefano Piras, Ana Werneck Capuano, Amanda Cook Maher, Rhiana Schafer et autres

As longevity increases and the population over age 65 expands, advancing age remains the most reliable predictor of cognitive decline, highlighting the need to identify biological mechanisms that support exceptional cognitive aging. We tested whether lower inherited risk of Alzheimer’s disease (AD) …

us, ca (code pays fourni par la source)

Associations of Alzheimer Disease and Related Dementia Neuropathologies With Timely Diagnosis of Dementia in Healthcare Settings

Yi Chen, Annie Chen, Melinda C. Power, Francine Grodstein et autres

BACKGROUND AND OBJECTIVES: A timely diagnosis of dementia may provide valuable time for treatment and planning, yet underdiagnosis is common. This study investigated the relationship between presence of dementia pathologies and timeliness of dementia diagnosis by healthcare providers. METHODS: This was a …

us (code pays fourni par la source)

Inflammatory proteins and cognitive decline in older black adults

Anat Yaskolka Meir, Henry A. Adeola, Shinya Tasaki, Liming Liang et autres

Strong evidence supports the role of low-grade systemic inflammation in neurodegeneration, including cognitive decline. Given the literature documenting chronic persistent inflammation in older Black adults, we investigated the association between circulating inflammatory proteins and cognitive decline in this high-risk population. We used …

us (code pays fourni par la source)

Sex Differences in the Association of Simultaneous Decline in Blood Pressure and Decline in Cognition during Aging

Nicholas W. Baumgartner, Ana Werneck Capuano, Lisa L. Barnes, David Alan Bennett et autres

OBJECTIVE: Both high and declining blood pressure (BP) are associated with risk of cognitive decline in older adults, and women have higher rates of hypertension and faster cognitive decline in late-life. In old age, the relationship between changes in BP and changes …

us (code pays fourni par la source)

COVID-19 Impact on Health Behaviors and Survey Engagement in Older African Americans: Longitudinal Cohort Study

Selda Yıldız, Nora Mattek, Joel S. Steele, Sarah Gothard et autres

BACKGROUND: The COVID-19 pandemic disrupted older adults' daily lives, particularly concerning social interaction, physical activity, and sleep quality. Older African Americans were disproportionately affected yet remain underrepresented in research documenting the impact of the COVID-19 pandemic. OBJECTIVE: This study investigated changes in …

us (code pays fourni par la source)

Operationalizing the neural exposome for brain health and Alzheimer’s Disease and Related Dementias (AD/ADRD) vulnerability in rural settings: pilot study

Juliana Nery Souza‐Talarico, Hans‐Joachim Lehmler, Jessica Caldwell, Yamnia Cortés et autres

Abstract INTRODUCTION Alzheimer’s disease and related dementias (AD/ADRD) arise from cumulative environmental, social, behavioral, and biological influences across the life course. The neural exposome framework conceptualizes how exogenous, behavioral, and endogenous factors interact to shape brain health; however, its application to preclinical …

us (code pays fourni par la source)

Age and the relation of common neuropathologies to dementia in Brazilian adults

José M. Farfel, Sukriti Nag, Ana Werneck Capuano, Maria CM Sampaio et autres

Background: Community-based clinical-pathologic studies have been instrumental to examine the association of Alzheimer's disease and related disorders (AD/ADRD) with age and dementia in very-old non-Latino Whites. Here, we show the age distribution of four AD and three additional common neuropathologies across the …

us, br (code pays fourni par la source)

What Makes a Neighborhood? Associations Between Behavioral and Psychosocial Factors and Perceptions of Neighborhood Environments Among Community-Dwelling Older Black and Latino Adults

Crystal M. Glover, Ana Werneck Capuano, Tianhao Wang, Brittney S. Lange-Maia et autres

How people perceive their neighborhoods can impact their aging trajectories, with less known regarding neighborhood perceptions among older adults from minoritized groups. This study examined the impacts of behavioral and psychosocial factors on neighborhood perceptions among non-Latino (NL) Black and Latino older …

us (code pays fourni par la source)

Brain‐peripheral proteome crosstalk in Alzheimer's disease with and without diabetes mellitus

Anat Yaskolka Meir, Xingyan Wang, Shinya Tasaki, Vishal Sarsani et autres

BACKGROUND: Although considerable research has investigated diabetes mellitus (DM) as a risk factor for Alzheimer's disease (AD) dementia, the mechanistic understanding of the associations between peripheral and central biological processes in AD and AD within DM remains limited. METHODS: We performed tandem …

us (code pays fourni par la source)

What Makes a Neighborhood? Associations Between Behavioral and Psychosocial Factors and Perceptions of Neighborhood Environments Among Community-Dwelling Older Black and Latino Adults

Crystal M. Glover, Ana Werneck Capuano, Tianhao Wang, Brittney S. Lange-Maia et autres

How people perceive their neighborhoods can impact their aging trajec-tories, with less known regarding neighborhood perceptions among older adults from minoritized groups. This study examined the impacts of be-havioral and psychosocial factors on neighborhood perceptions among Non-Latino (NL) Black and Latino older …

us (code pays fourni par la source)

Discrimination and allostatic load in black middle-aged and older adults: A systematic review and meta-analysis

Alaa Harb, Juliana Nery Souza‐Talarico, Karen A. Lawrence, Jihye Lee et autres

us, ph (code pays fourni par la source)