Samina Shaheen

SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation

Chenyang Guan, Xian Huang, Jinnan Yue, Hongrui Xiang et autres

infection.

cn (code pays fourni par la source)

A PI(4,5)P2‐derived “gasoline engine model” for the sustained B cell receptor activation

Chenguang Xu, Zhengpeng Wan, Samina Shaheen, Jing Wang et autres

To efficiently initiate activation responses against rare ligands in the microenvironment, lymphocytes employ sophisticated mechanisms involving signaling amplification. Recently, a signaling amplification mechanism initiated from phosphatidylinositol (PI) 4, 5-biphosphate [PI(4,5)P2] hydrolysis and synthesis for sustained B cell activation has been reported. Antigen …

kr, cn, us (code pays fourni par la source)

Imaging: Gear up for mechano-immunology

Zhengpeng Wan, Samina Shaheen, Alicia Chau, Yingyue Zeng et autres

us, cn (code pays fourni par la source)

B cell mechanosensing: A mechanistic overview

Samina Shaheen, Zhengpeng Wan, Kabeer Haneef, Yingyue Zeng et autres

cn (code pays fourni par la source)

PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation

Zhengpeng Wan, Chenguang Xu, Xiangjun Chen, Hengyi Xie et autres

B lymphocytes use B cell receptors (BCRs) to sense the chemical and physical features of antigens. The activation of isotype-switched IgG-BCR by mechanical force exhibits a distinct sensitivity and threshold in comparison with IgM-BCR. However, molecular mechanisms governing these differences remain to …

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PI3K- and PTEN-Governed PIP2 and PIP3 Equilibrium Regulates the Activation and Function of B Cells Through Dock2 Controlled Growth of Antigen Receptor Microclusters

Jing Wang, Liling Xu, Samina Shaheen, Sichen Liu et autres

cn (code pays fourni par la source)

Detection and Molecular Typing of Extended Spectrum Beta Lactamases (ESBLs) Producing Gram-Negative Bacteria from Wound Infections

Yasra Sarwar, Samina Shaheen, Naila Mushtaq, Abdul Haque

ABSTRACT: Extended spectrum β-lactamases (ESBLs) producing bacteria, which are mainly Gram-negative, have emerged as a major threat in recent years as they are resistant to most antimicrobials. This study was conducted to investigate the prevalence of ESBL producing Gram-negative bacteria in woundinfections …

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Growth of B Cell Receptor Microclusters Is Regulated by PIP2 and PIP3 Equilibrium and Dock2 Recruitment and Activation

Jing Wang, Liling Xu, Samina Shaheen, Sichen Liu et autres

The growth of B cell receptor (BCR) microclusters upon antigen stimulation drives B cell activation. Here, we show that PI3K-mediated PIP 3 production is required for the growth of BCR microclusters. This growth is likely inhibited by PTEN and dependent on its …

cn (code pays fourni par la source)

Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

Samina Shaheen, Zhengpeng Wan, Zongyu Li, Alicia Chau et autres

The mechanosensing ability of lymphocytes regulates their activation in response to antigen stimulation, but the underlying mechanism remains unexplored. Here, we report that B cell mechanosensing-governed activation requires BCR signaling molecules. PMA-induced activation of PKCβ can bypass the Btk and PLC-γ2 signaling …

cn (code pays fourni par la source)

Author response: Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

Samina Shaheen, Zhengpeng Wan, Zongyu Li, Alicia Chau et autres

The combination of molecular imaging, genetic and pharmacological approaches revealed that BCR signaling and PKCβ-dependent activation of focal adhesion kinase (FAK) is required for B cell mechanosensing.

cn, in, gb, hr (code pays fourni par la source)

A negative-feedback function of PKCβ in the formation and accumulation of signaling-active B cell receptor microclusters within B cell immunological synapse

Ce Liu, Xingwang Zhao, Liling Xu, Junyang Yi et autres

Abstract Advanced live cell imaging studies suggested that B cell activation is initiated by the formation of BCR microclusters and subsequent B cell IS upon BCR and antigen recognition. PKC family member PKCβ is highly expressed in B cells and plays an …

cn (code pays fourni par la source)

Through an ITIM-Independent Mechanism the FcγRIIB Blocks B Cell Activation by Disrupting the Colocalized Microclustering of the B Cell Receptor and CD19

Liling Xu, Gen Li, Jing Wang, Yilin Fan et autres

B cell activation is regulated through the interplay of the BCR with the inhibitory coreceptor FcγRIIB and the activating coreceptor CD19. Recent studies suggest that Ag-driven BCR microclusters are efficiently converted to a signaling active state on colocalization with CD19 microclusters. Using …

cn, kr, us (code pays fourni par la source)