Paola Pedarzani

Tunable hydrogel-based micropillar arrays for myelination studies

Soufian Lasli, Claire Vinel, Ayushi Agrawal, Yousef Javanmardi et autres

Oligodendrocytes enable rapid central nervous system signaling by myelinating axons. Here, to model key biomechanical cues regulating myelination, we developed a tunable hydrogel-based micropillar array system that mimics the three-dimensional architecture and softness of axons. This platform supports the long-term culture of …

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Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sIAHP, and its potentiation in hippocampal pyramidal neurons

A Tedoldi, Petra Ludwig, Gianluca Fulgenzi, Hiroshi Takeshima et autres

The slow afterhyperpolarising current, sIAHP, is a Ca2+-dependent current that plays an important role in the late phase of spike frequency adaptation. sIAHP is activated by voltage-gated Ca2+ channels, while the contribution of calcium from ryanodine-sensitive intracellular stores, released by calcium-induced calcium …

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Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sI AHP , and its potentiation in hippocampal pyramidal neurons

A Tedoldi, Petra Ludwig, Gianluca Fulgenzi, Hiroshi Takeshima et autres

Abstract The slow afterhyperpolarising current, sI AHP , is a Ca 2+ -dependent current that plays an important role in the late phase of spike frequency adaptation. sI AHP is activated by voltage-gated Ca 2+ channels, while the contribution of calcium from …

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Benzamil inhibits neuronal and heterologously expressed small conductance Ca2+-activated K+ channels

Marisol Sampedro Castañeda, Raffaella Tonini, Christopher D. Richards, Martin Stocker et autres

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Role of calcium-induced calcium release and type 3 ryanodine receptors in the regulation of the slow afterhyperpolarising current,sI(AHP), and its potentiation in hippocampal pyramidal neurones

A Tedoldi, Petra Ludwig, Gianluca Fulgenzi, N Dalgleish et autres

Developmental mapping of small‐conductance calcium‐activated potassium channel expression in the rat nervous system

Marco Gymnopoulos, Lorenzo A. Cingolani, Paola Pedarzani, Martin Stocker

Early electrical activity and calcium influx regulate crucial aspects of neuronal development. Small-conductance calcium-activated potassium (SK) channels regulate action potential firing and shape calcium influx through feedback regulation in mature neurons. These functions, observed in the adult nervous system, make them ideal …

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Pituitary adenylate cyclase‐activating polypeptide (PACAP) inhibits the slow afterhyperpolarizing current sIAHPin CA1 pyramidal neurons by activating multiple signaling pathways

R Taylor, Marita Grønning Madsen, Michael Krause, Marisol Sampedro Castañeda et autres

The slow afterhyperpolarizing current (sIAHP ) is a calcium-dependent potassium current that underlies the late phase of spike frequency adaptation in hippocampal and neocortical neurons. sIAHP is a well-known target of modulation by several neurotransmitters acting via the cyclic AMP (cAMP) and …

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Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons

Raffaella Tonini, Teresa Ferraro, Marisol Sampedro Castañeda, Anna Cavaccini et autres

In hippocampal pyramidal neurons, voltage-gated Ca(2+) channels open in response to action potentials. This results in elevations in the intracellular concentration of Ca(2+) that are maximal in the proximal apical dendrites and decrease rapidly with distance from the soma. The control of …

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Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity

Derek A. Costello, Marc Claret, Hind Al‐Qassab, Florian Plattner et autres

OBJECTIVE: Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia, particularly in the elderly. These deficits and the corresponding neurophysiological structural and functional alterations are linked to both metabolic and vascular changes, related to chronic hyperglycaemia, but probably …

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SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance

Cristiano Nazzaro, Barbara Greco, Milica Cerovic, Paul Baxter et autres

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Mitral Cells of the Olfactory Bulb Perform Metabolic Sensing and Are Disrupted by Obesity at the Level of the Kv1.3 Ion Channel

Debra Ann Fadool, Kristal R. Tucker, Paola Pedarzani

Sixty-five percent of Americans are over-weight. While the neuroendocrine controls of energy homeostasis are well known, how sensory systems respond to and are impacted by obesity is scantily understood. The main accepted function of the olfactory system is to provide an internal …

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The Olfactory Bulb: A Metabolic Sensor of Brain Insulin and Glucose Concentrations via a Voltage-Gated Potassium Channel

Kristal R. Tucker, Melissa Ann Cavallin, Patrick Jean-Baptiste, K.C. Biju et autres

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